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Feasibility of a stereoselective synthesis of [11C](S, S)-S-adenosylmethionine ([11C](S,S)-SAM) catalyzed by an immobilized enzyme

This work aims to develop a stereoselective enzymatic alternative for the radiosynthesis of [11C](S,S)-S-ade-nosylmethionine ([11C](S,S)-SAM), a potential PET-CT radiotracer for monitoring particularly aggressive prostate tumors. Conventional synthesis of this compound has been carried out at Urugua...

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Main Author: Diego, Umpiérrez Puchalvert (author)
Other Authors: Florencia, Zoppolo (author), Manuela Bentura (author), Agustin, Castilla (author), Eduardo, Savio (author), Sonia, Rodríguez Giordano (author), Gabriela, Irazoqui (author)
Format: article
Language:English
Published: 2024
Subjects:
Enzymatic radiosynthesis
SAM
S-adenosylmethionine
Methionine adenosyltransferase
Immobilized enzyme
Prostate cancer radiotracer
Stereospecificity
Ciencias Naturales y Exactas
Ciencias Químicas
Online Access:https://hdl.handle.net/20.500.12381/5578
https://doi.org/10.1016/j.procbio.2024.12.006
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