Electrophiles modulate glutathione reductase activity via alkylation and upregulation of glutathione biosynthesis

Cells evolved robust homeostatic mechanisms to protect against oxidation or alkylation by electrophilic species. Glutathione (GSH) is the most abundant intracellular thiol, protects cellular components from oxidation and is maintained in a reduced state by glutathione reductase (GR). Nitro oleic aci...

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Bibliographic Details

Main Author:	Jobbagy, S. (author)
Other Authors:	Vitturi, D.A. (author), Salvatore, S.R. (author), Turell Novo, Lucía (author), Pires, M.F. (author), Kansanen, E. (author), Batthyány Dighiero, Carlos (author), Lancaster, J.R. (author), Freeman, B.A. (author), Schopfer, F.J. (author)
Format:	article
Language:	English
Published:	2019
Subjects:	Glutathione Glutathione reductase Electrophile Nitrated fatty acid Disulfide Nrf2 Thiol Oxidation-reduction (redox)
Online Access:	https://hdl.handle.net/20.500.12008/27224
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