Multiple oxidative post-translational modifications of human glutamine synthetase mediate peroxynitrite-dependent enzyme inactivation and aggregation
Glutamine synthetase (GS), which catalyzes the ATPdependent synthesis of L-glutamine from L-glutamate and ammonia, is a ubiquitous and conserved enzyme that plays a pivotal role in nitrogen metabolism across all life domains. In vertebrates, GS is highly expressed in astrocytes, where its activity s...
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| Další autoři: | , , , , , , , , |
| Médium: | article |
| Jazyk: | angličtina |
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2023
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| On-line přístup: | https://hdl.handle.net/20.500.12008/52317 |
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