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Multiple oxidative post-translational modifications of human glutamine synthetase mediate peroxynitrite-dependent enzyme inactivation and aggregation

Glutamine synthetase (GS), which catalyzes the ATPdependent synthesis of L-glutamine from L-glutamate and ammonia, is a ubiquitous and conserved enzyme that plays a pivotal role in nitrogen metabolism across all life domains. In vertebrates, GS is highly expressed in astrocytes, where its activity s...

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Main Author: Campolo, Nicolás (author)
Other Authors: Mastrogiovanni, Mauricio (author), Mariotti, Michele (author), Issoglio, Fernando M. (author), Estrin, Darío (author), Hägglund, Per (author), Grune, Tilman (author), Davies, Michael J. (author), Bartesaghi, Silvina (author), Radi, Rafael (author)
Format: article
Language:English
Published: 2023
Subjects:
Aggregation
Dityrosine
Free radicals
Glutamine synthetase
Hydrogen peroxide
Nitrotyrosine
Oxidants
Peroxynitrite
Thiol oxidation
CROMATOGRAFÍA LÍQUIDA
ACTIVACIÓN ENZIMÁTICA
EFECTOS FISIOLÓGICOS DE LAS DROGAS
GENÉTICA
METABOLISMO
GLUTAMATO-AMONÍACO LIGASA
MUTACIÓN
OXIDACIÓN-REDUCCIÓN
HUMANOS
ÁCIDO PEROXINITROSO
FARMACOLOGÍA
AGREGACIÓN PATOLÓGICA DE PROTEÍNAS
PROCESAMIENTO PROTEICO-POSTRADUCCIONAL
ESPECTROMETRÍA DE MASAS EN TÁNDEM
TIROSINA
Online Access:https://hdl.handle.net/20.500.12008/52317
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