Design of a genetically stable high fidelity coxsackievirus B3 polymerase that attenuates virus growth in vivo
Positive strand RNA viruses replicate via a virally encoded RNA-dependent RNA polymerase (RdRP) that uses a unique palm domain active site closure mechanism to establish the canonical two-metal geometry needed for catalysis. This mechanism allows these viruses to evolutionarily fine-tune their repli...
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| Tác giả khác: | , , , , |
| Định dạng: | article |
| Ngôn ngữ: | Tiếng Anh |
| Được phát hành: |
2016
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| Những chủ đề: | |
| Truy cập trực tuyến: | https://hdl.handle.net/20.500.12008/22047 |
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