Design of a genetically stable high fidelity coxsackievirus B3 polymerase that attenuates virus growth in vivo

Positive strand RNA viruses replicate via a virally encoded RNA-dependent RNA polymerase (RdRP) that uses a unique palm domain active site closure mechanism to establish the canonical two-metal geometry needed for catalysis. This mechanism allows these viruses to evolutionarily fine-tune their repli...

Full description

Bibliographic Details

Main Author:	McDonald, S. (author)
Other Authors:	Block, A. (author), Beaucourt, Stéphanie (author), Moratorio, Gonzalo (author), Vignuzzi, Marco (author), Peersen, O. B. (author)
Format:	article
Language:	English
Published:	2016
Subjects:	Amino acids Polymers Genetic variants Infectious virus Enterovirus Protein Conformation RNA Replicase Virus Replication
Online Access:	https://hdl.handle.net/20.500.12008/22047
Tags:	Add Tag No Tags, Be the first to tag this record!