Post-paralysis tyrosine kinase inhibition with masitinib abrogates neuroinflammation and slows disease progression in inherited amyotrophic lateral sclerosis

Background: In the SOD1G93A mutant rat model of amyotrophic lateral sclerosis (ALS), neuronal death and rapid paralysis progression are associated with the emergence of activated aberrant glial cells that proliferate in the degenerating spinal cord. Whether pharmacological downregulation of such abe...

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Үндсэн зохиолч:	Trias, Emiliano (author)
Бусад зохиолчид:	Ibarburu, Sofía (author), Barreto-Núñez, Romina (author), Babdor, Joël (author), Maciel, Thiago T. (author), Guillo, Matthias (author), Gros, Laurent (author), Dubreuil, Patrice (author), Díaz-Amarilla, Pablo (author), Cassina, Patricia (author), Martínez-Palma, Laura (author), Moura, Ivan C. (author), Beckman, Joseph S. (author), Hermine, Olivier (author), Barbeito, Luis (author)
Формат:	article
Хэл сонгох:	англи
Хэвлэсэн:	2016
Нөхцлүүд:	ALS Aberrant glial cells Neurodegeneration Masitinib M-CSF Ciencias Médicas y de la Salud Biotecnología de la Salud
Онлайн хандалт:	http://hdl.handle.net/20.500.12381/169 http://dx.doi.org/10.1186/s12974-016-0620-9
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!