Post-paralysis tyrosine kinase inhibition with masitinib abrogates neuroinflammation and slows disease progression in inherited amyotrophic lateral sclerosis

Background: In the SOD1G93A mutant rat model of amyotrophic lateral sclerosis (ALS), neuronal death and rapid paralysis progression are associated with the emergence of activated aberrant glial cells that proliferate in the degenerating spinal cord. Whether pharmacological downregulation of such abe...

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Bibliographic Details

Main Author:	Trias, Emiliano (author)
Other Authors:	Ibarburu, Sofía (author), Barreto-Núñez, Romina (author), Babdor, Joël (author), Maciel, Thiago T. (author), Guillo, Matthias (author), Gros, Laurent (author), Dubreuil, Patrice (author), Díaz-Amarilla, Pablo (author), Cassina, Patricia (author), Martínez-Palma, Laura (author), Moura, Ivan C. (author), Beckman, Joseph S. (author), Hermine, Olivier (author), Barbeito, Luis (author)
Format:	article
Language:	English
Published:	2016
Subjects:	ALS Aberrant glial cells Neurodegeneration Masitinib M-CSF Ciencias Médicas y de la Salud Biotecnología de la Salud
Online Access:	http://hdl.handle.net/20.500.12381/169 http://dx.doi.org/10.1186/s12974-016-0620-9
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