Paternal methotrexate exposure affects sperm small RNA content and causes craniofacial defects in the offspring

Folate is an essential vitamin for vertebrate embryo development. Methotrexate (MTX) is a folate antagonist that is widely prescribed for autoimmune diseases, blood and solid organ malignancies, and dermatologic diseases. Although it is highly contraindicated for pregnant women, because it is associ...

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Bibliographic Details

Main Author:	Alata Jimenez, Nagif (author)
Other Authors:	Castellano, Mauricio (author), Santillan, Emilio M. (author), Boulias, Konstantinos (author), Boan, Agustín (author), Arias Padilla, Luisa F. (author), Fernandino, Juan I. (author), Greer, Eric L. (author), Tosar Rovira, Juan Pablo (author), Cochella, Luisa (author), Strobl-Mazzulla, Pablo H. (author)
Format:	article
Language:	English
Published:	2023
Subjects:	Methotrexate Folate deficiency Sperm RNA Craniofacial defects
Online Access:	https://hdl.handle.net/20.500.12008/42745
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