Escaping from flatland: 3D carborane-based bioisosteres of Erlotinib as potential anticancer agents

Phenyl rings are present in nearly 45% of approved small-molecule drugs; however, their flat, aromatic nature can lead to poor solubility, metabolic instability, and limited target selectivity. Carboranes, as three-dimensional boron-rich bioisosteres, may offer a promising alternative to address the...

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Bibliographic Details

Main Author:	Dávila Saralegui, Belén (author)
Other Authors:	Vignolo, Pablo (author), González Alayón, Ignacio Darwin (author), Lecot Calandria, Nicole Valerie (author), Bonanata, Jenner (author), García, María Fernanda (author), Echeverría, Gonzalo A. (author), Piro, Oscar E. (author), Cerecetto, Hugo (author), Couto, Marcos (author)
Format:	article
Language:	English
Published:	2025
Subjects:	NEOPLASMAS MALIGNOS TERAPEUTICA GLIOBLASTOMAS FARMACOLOGIA
Online Access:	https://hdl.handle.net/20.500.12008/53047
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