Escaping from flatland: 3D carborane-based bioisosteres of Erlotinib as potential anticancer agents
Phenyl rings are present in nearly 45% of approved small-molecule drugs; however, their flat, aromatic nature can lead to poor solubility, metabolic instability, and limited target selectivity. Carboranes, as three-dimensional boron-rich bioisosteres, may offer a promising alternative to address the...
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| Other Authors: | , , , , , , , , |
| Format: | article |
| Language: | English |
| Published: |
2025
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| Online Access: | https://hdl.handle.net/20.500.12008/53047 |
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