Escaping from flatland: 3D carborane-based bioisosteres of Erlotinib as potential anticancer agents

Phenyl rings are present in nearly 45% of approved small-molecule drugs; however, their flat, aromatic nature can lead to poor solubility, metabolic instability, and limited target selectivity. Carboranes, as three-dimensional boron-rich bioisosteres, may offer a promising alternative to address the...

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Kaituhi matua:	Dávila Saralegui, Belén (author)
Ētahi atu kaituhi:	Vignolo, Pablo (author), González Alayón, Ignacio Darwin (author), Lecot Calandria, Nicole Valerie (author), Bonanata, Jenner (author), García, María Fernanda (author), Echeverría, Gonzalo A. (author), Piro, Oscar E. (author), Cerecetto, Hugo (author), Couto, Marcos (author)
Hōputu:	article
Reo:	Ingarihi
I whakaputaina:	2025
Ngā marau:	NEOPLASMAS MALIGNOS TERAPEUTICA GLIOBLASTOMAS FARMACOLOGIA
Urunga tuihono:	https://hdl.handle.net/20.500.12008/53047
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!