Crystal structure of Trypanosoma cruzi heme peroxidase and characterization of its substrate specificity and compound I intermediate

The protozoan parasite Trypanosoma cruzi is the causative agent of American trypanosomiasis, otherwise known as Chagas disease. To survive in the host, the T. cruzi parasite needs antioxidant defense systems. One of these is a hybrid heme peroxidase, the T. cruzi ascorbate peroxidase-cytochrome c pe...

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Bibliographic Details

Main Author:	Freeman, Samuel L. (author)
Other Authors:	Skafar Amen, Vera (author), Kwon, Hanna (author), Fielding, Alistair J. (author), Moody, Peter C. E. (author), Martínez, Alejandra (author), Issoglio, Federico M. (author), Inchausti, Lucas (author), Smircich, Pablo (author), Zeida, Ari (author), Piacenza, Lucía (author), Radi, Rafael (author), Raven, Emma L. (author)
Format:	article
Language:	English
Published:	2022
Subjects:	Peroxidase Chagas disease Ascorbate Cytochrome C. Heme Oxidants
Online Access:	https://hdl.handle.net/20.500.12008/38476
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