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Signal-regulatory protein alpha is an anti-viral entry factor targeting viruses using endocytic pathways

Signal-regulatory protein alpha (SIRPA) is a well-known inhibitor of phagocytosis when it complexes with CD47 expressed on target cells. Here we show that SIRPA decreased in vitro infection by a number of pathogenic viruses, including New World and Old World arena-viruses, Zika virus, vesicular stom...

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Hlavní autor: Sarute, Nicolás (author)
Další autoři: Cheng, Han (author), Yan, Zhonghao (author), Salas-Briceno, Karen (author), Richne, Justin (author), Rong, Lijun (author), Ross, S. R. (author)
Médium: article
Jazyk:angličtina
Vydáno: 2021
Témata:
Vesicular stomatitis virus
Ebola virus
Small interfering RNA
Phagocytosis
SARS CoV 2
293T cells
Transfection
Machupo Virus
On-line přístup:https://hdl.handle.net/20.500.12008/38247
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