Intensity distribution segmentation in ultrafast Doppler combined with scanning laser confocal microscopy for assessing vascular changes associated with ageing in murine hippocampi.
The hippocampus plays an important role in learning and memory, requiring high-neuronal oxygenation. Understanding the relationship between blood flow and vascular structure—and how it changes with ageing—is physiologically and anatomically relevant. Ultrafast Doppler ( μDoppler) and scanning laser...
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| Altres autors: | , , , , , , , , , |
| Format: | article |
| Idioma: | anglès |
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2022
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| Accés en línia: | https://hdl.handle.net/20.500.12008/38319 |
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| _version_ | 1868890199498424320 |
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| author | Anzibar Fialho, Maximiliano |
| author2 | Vázquez Alberdi, Lucía Martínez, Mariana Calero, Miguel Baranger, Jerome Tanter, Mickael Damián, Juan Pablo Negreira, Carlos Rubido, Nicolás Kun González, Alejandra E. Brum, Javier |
| author2_role | author author author author author author author author author author |
| author_browse | Anzibar Fialho, Maximiliano Baranger, Jerome Brum, Javier Calero, Miguel Damián, Juan Pablo Kun González, Alejandra E. Martínez, Mariana Negreira, Carlos Rubido, Nicolás Tanter, Mickael Vázquez Alberdi, Lucía |
| author_facet | Anzibar Fialho, Maximiliano Vázquez Alberdi, Lucía Martínez, Mariana Calero, Miguel Baranger, Jerome Tanter, Mickael Damián, Juan Pablo Negreira, Carlos Rubido, Nicolás Kun González, Alejandra E. Brum, Javier |
| author_role | author |
| collection | COLIBRI |
| dc.contributor.none.fl_str_mv | Anzibar Fialho Maximiliano, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Física. Vázquez Alberdi Lucía, IIBCE Martínez Mariana, IIBCE Calero Miguel Baranger Jerome Tanter Mickael Damián Juan Pablo, Universidad de la República (Uruguay). Facultad de Veterinaria. Negreira Carlos, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Física. Rubido Nicolás, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Física. Kun González Alejandra E., Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. Brum Javier, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Física. |
| dc.creator.none.fl_str_mv | Anzibar Fialho, Maximiliano Vázquez Alberdi, Lucía Martínez, Mariana Calero, Miguel Baranger, Jerome Tanter, Mickael Damián, Juan Pablo Negreira, Carlos Rubido, Nicolás Kun González, Alejandra E. Brum, Javier |
| dc.date.none.fl_str_mv | 2022 2023-07-21T16:16:56Z 2023-07-21T16:16:56Z |
| dc.format.none.fl_str_mv | 10 h. application/pdf |
| dc.identifier.none.fl_str_mv | Anzibar Fialho, M, Vázquez Alberdi, L, Martínez, M, [y otros autores]. "Intensity distribution segmentation in ultrafast Doppler combined with scanning laser confocal microscopy for assessing vascular changes associated with ageing in murine hippocampi". Scientific Reports. [en línea] 2022, 12(1):6784.10 h. DOI: 10.1038/s41598-022-10457-9 2045-2322 https://hdl.handle.net/20.500.12008/38319 10.1038/s41598-022-10457-9 |
| dc.language.none.fl_str_mv | en_US eng |
| dc.publisher.none.fl_str_mv | Springer Nature |
| dc.relation.none.fl_str_mv | Scientific Reports, 2022, 12(1):6784. |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.none.fl_str_mv | Ageing Confocal microscopy Imaging techniques Neural ageing Ultrasound |
| dc.title.none.fl_str_mv | Intensity distribution segmentation in ultrafast Doppler combined with scanning laser confocal microscopy for assessing vascular changes associated with ageing in murine hippocampi. |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | The hippocampus plays an important role in learning and memory, requiring high-neuronal oxygenation. Understanding the relationship between blood flow and vascular structure—and how it changes with ageing—is physiologically and anatomically relevant. Ultrafast Doppler ( μDoppler) and scanning laser confocal microscopy (SLCM) are powerful imaging modalities that can measure in vivo cerebral blood volume (CBV) and post mortem vascular structure, respectively. Here, we apply both imaging modalities to a cross-sectional and longitudinal study of hippocampi vasculature in wild-type mice brains. We introduce a segmentation of CBV distribution obtained from μDoppler and show that this mice-independent and mesoscopic measurement is correlated with vessel volume fraction (VVF) distribution obtained from SLCM—e.g., high CBV relates to specific vessel locations with large VVF. Moreover, we find significant changes in CBV distribution and vasculature due to ageing (5 vs. 21 month-old mice), highlighting the sensitivity of our approach. Overall, we are able to associate CBV with vascular structure—and track its longitudinal changes—at the artery-vein, venules, arteriole, and capillary levels. We believe that this combined approach can be a powerful tool for studying other acute (e.g., brain injuries), progressive (e.g., neurodegeneration) or induced pathological changes. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_d191a93ea9cbfe3cbed4650995bdafe4 |
| identifier_str_mv | Anzibar Fialho, M, Vázquez Alberdi, L, Martínez, M, [y otros autores]. "Intensity distribution segmentation in ultrafast Doppler combined with scanning laser confocal microscopy for assessing vascular changes associated with ageing in murine hippocampi". Scientific Reports. [en línea] 2022, 12(1):6784.10 h. DOI: 10.1038/s41598-022-10457-9 2045-2322 10.1038/s41598-022-10457-9 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en_US |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/38319 |
| publishDate | 2022 |
| publishDateSort | 2022 |
| publisher.none.fl_str_mv | Springer Nature |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
| spelling | Intensity distribution segmentation in ultrafast Doppler combined with scanning laser confocal microscopy for assessing vascular changes associated with ageing in murine hippocampi.Anzibar Fialho, MaximilianoVázquez Alberdi, LucíaMartínez, MarianaCalero, MiguelBaranger, JeromeTanter, MickaelDamián, Juan PabloNegreira, CarlosRubido, NicolásKun González, Alejandra E.Brum, JavierAgeingConfocal microscopyImaging techniquesNeural ageingUltrasoundThe hippocampus plays an important role in learning and memory, requiring high-neuronal oxygenation. Understanding the relationship between blood flow and vascular structure—and how it changes with ageing—is physiologically and anatomically relevant. Ultrafast Doppler ( μDoppler) and scanning laser confocal microscopy (SLCM) are powerful imaging modalities that can measure in vivo cerebral blood volume (CBV) and post mortem vascular structure, respectively. Here, we apply both imaging modalities to a cross-sectional and longitudinal study of hippocampi vasculature in wild-type mice brains. We introduce a segmentation of CBV distribution obtained from μDoppler and show that this mice-independent and mesoscopic measurement is correlated with vessel volume fraction (VVF) distribution obtained from SLCM—e.g., high CBV relates to specific vessel locations with large VVF. Moreover, we find significant changes in CBV distribution and vasculature due to ageing (5 vs. 21 month-old mice), highlighting the sensitivity of our approach. Overall, we are able to associate CBV with vascular structure—and track its longitudinal changes—at the artery-vein, venules, arteriole, and capillary levels. We believe that this combined approach can be a powerful tool for studying other acute (e.g., brain injuries), progressive (e.g., neurodegeneration) or induced pathological changes.ANII: FCE_1_2019_1_155539Springer NatureAnzibar Fialho Maximiliano, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Física.Vázquez Alberdi Lucía, IIBCEMartínez Mariana, IIBCECalero MiguelBaranger JeromeTanter MickaelDamián Juan Pablo, Universidad de la República (Uruguay). Facultad de Veterinaria.Negreira Carlos, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Física.Rubido Nicolás, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Física.Kun González Alejandra E., Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología.Brum Javier, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Física.2023-07-21T16:16:56Z2023-07-21T16:16:56Z2022Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion10 h.application/pdfAnzibar Fialho, M, Vázquez Alberdi, L, Martínez, M, [y otros autores]. "Intensity distribution segmentation in ultrafast Doppler combined with scanning laser confocal microscopy for assessing vascular changes associated with ageing in murine hippocampi". Scientific Reports. [en línea] 2022, 12(1):6784.10 h. DOI: 10.1038/s41598-022-10457-92045-2322https://hdl.handle.net/20.500.12008/3831910.1038/s41598-022-10457-9reponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la Repúblicaen_USengScientific Reports, 2022, 12(1):6784.Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0)oai:colibri.udelar.edu.uy:20.500.12008/383192026-04-14T10:10:08Z |
| spellingShingle | Intensity distribution segmentation in ultrafast Doppler combined with scanning laser confocal microscopy for assessing vascular changes associated with ageing in murine hippocampi. Anzibar Fialho, Maximiliano Ageing Confocal microscopy Imaging techniques Neural ageing Ultrasound |
| status_str | publishedVersion |
| title | Intensity distribution segmentation in ultrafast Doppler combined with scanning laser confocal microscopy for assessing vascular changes associated with ageing in murine hippocampi. |
| title_full | Intensity distribution segmentation in ultrafast Doppler combined with scanning laser confocal microscopy for assessing vascular changes associated with ageing in murine hippocampi. |
| title_fullStr | Intensity distribution segmentation in ultrafast Doppler combined with scanning laser confocal microscopy for assessing vascular changes associated with ageing in murine hippocampi. |
| title_full_unstemmed | Intensity distribution segmentation in ultrafast Doppler combined with scanning laser confocal microscopy for assessing vascular changes associated with ageing in murine hippocampi. |
| title_short | Intensity distribution segmentation in ultrafast Doppler combined with scanning laser confocal microscopy for assessing vascular changes associated with ageing in murine hippocampi. |
| title_sort | Intensity distribution segmentation in ultrafast Doppler combined with scanning laser confocal microscopy for assessing vascular changes associated with ageing in murine hippocampi. |
| topic | Ageing Confocal microscopy Imaging techniques Neural ageing Ultrasound |
| url | https://hdl.handle.net/20.500.12008/38319 |