Design and development of 6-hydrazinonicotinylfatty acid-mimetic 99mTc-complex as a potential myocardial imaging agent
The goal of this work is to identify new fatty acid-mimetic 99mTc-complexes to be used as myocardial imaging agents that allow studying heart abnormalities in high-risk patients. In this sense, we designed a fatty acid-mimetic substructure including an amide moiety that, among other properties, coul...
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| Otros Autores: | , , , |
| Formato: | article |
| Lenguaje: | inglés |
| Publicado: |
2024
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| Acceso en línea: | https://hdl.handle.net/20.500.12008/50287 |
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| _version_ | 1868890116473225216 |
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| author | González, Joel |
| author2 | García, María Fernanda Cabral González, Pablo Calzada, Victoria Cerecetto, Hugo |
| author2_role | author author author author |
| author_browse | Cabral González, Pablo Calzada, Victoria Cerecetto, Hugo García, María Fernanda González, Joel |
| author_facet | González, Joel García, María Fernanda Cabral González, Pablo Calzada, Victoria Cerecetto, Hugo |
| author_role | author |
| collection | COLIBRI |
| dc.contributor.none.fl_str_mv | González Joel, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares. García María Fernanda, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares. Cabral González Pablo, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares. Calzada Victoria, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares. Cerecetto Hugo, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares. |
| dc.creator.none.fl_str_mv | González, Joel García, María Fernanda Cabral González, Pablo Calzada, Victoria Cerecetto, Hugo |
| dc.date.none.fl_str_mv | 2024 2025-06-11T18:00:57Z 2025-06-11T18:00:57Z |
| dc.format.none.fl_str_mv | 13 h application/pdf |
| dc.identifier.none.fl_str_mv | González, J, García, M, Cabral González, P [y otros autores]. "Design and development of 6-hydrazinonicotinylfatty acid-mimetic 99mTc-complex as a potential myocardial imaging agent". Brazilian Journal of Pharmaceutical Sciences. [en línea] 2024, 60: e23542. 13 h. DOI: 10.1590/s2175-97902024e23542 2175-9790 https://hdl.handle.net/20.500.12008/50287 10.1590/s2175-97902024e23542 |
| dc.language.none.fl_str_mv | en eng |
| dc.publisher.none.fl_str_mv | Universidade de São Paulo |
| dc.relation.none.fl_str_mv | Brazilian Journal of Pharmaceutical Sciences, 2024, 60: e23542. |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess Licencia Creative Commons Atribución (CC - By 4.0) |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.none.fl_str_mv | Technetium Radiopharmaceutical Myocardial metabolism Long chain amide |
| dc.title.none.fl_str_mv | Design and development of 6-hydrazinonicotinylfatty acid-mimetic 99mTc-complex as a potential myocardial imaging agent |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | The goal of this work is to identify new fatty acid-mimetic 99mTc-complexes to be used as myocardial imaging agents that allow studying heart abnormalities in high-risk patients. In this sense, we designed a fatty acid-mimetic substructure including an amide moiety that, among other properties, could improve myocardial residence time. A diamide with a chain length of 15 atoms and porting a 6-hydrazinonicotinyl (HYNIC) chelator, and an analog with a short carbon-chain, were prepared with convergent organic synthetic procedures and radiolabeled with 99mTc using tricine as the sole coligand. The in vivo proofs of concept were performed using healthy mice. The new 99mTc-complexes were obtained with adequate radiochemical purity. The lipophilicities were in agreement with the length of the chains. While both 99mTccomplexes showed uptake in the myocardial muscle, the designed radiopharmaceutical with the longest chain length had preferential target-uptake and target-retention compared to other complexes described in the bibliography. Further studies, involving imaging assays, synthetic modifications, and assay of new coligands for 99mTc-HYNIC complexes, are currently ongoing. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_877a90395a06f83435128e8a092e8d13 |
| identifier_str_mv | González, J, García, M, Cabral González, P [y otros autores]. "Design and development of 6-hydrazinonicotinylfatty acid-mimetic 99mTc-complex as a potential myocardial imaging agent". Brazilian Journal of Pharmaceutical Sciences. [en línea] 2024, 60: e23542. 13 h. DOI: 10.1590/s2175-97902024e23542 2175-9790 10.1590/s2175-97902024e23542 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/50287 |
| publishDate | 2024 |
| publishDateSort | 2024 |
| publisher.none.fl_str_mv | Universidade de São Paulo |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| spelling | Design and development of 6-hydrazinonicotinylfatty acid-mimetic 99mTc-complex as a potential myocardial imaging agentGonzález, JoelGarcía, María FernandaCabral González, PabloCalzada, VictoriaCerecetto, HugoTechnetiumRadiopharmaceuticalMyocardial metabolismLong chain amideThe goal of this work is to identify new fatty acid-mimetic 99mTc-complexes to be used as myocardial imaging agents that allow studying heart abnormalities in high-risk patients. In this sense, we designed a fatty acid-mimetic substructure including an amide moiety that, among other properties, could improve myocardial residence time. A diamide with a chain length of 15 atoms and porting a 6-hydrazinonicotinyl (HYNIC) chelator, and an analog with a short carbon-chain, were prepared with convergent organic synthetic procedures and radiolabeled with 99mTc using tricine as the sole coligand. The in vivo proofs of concept were performed using healthy mice. The new 99mTc-complexes were obtained with adequate radiochemical purity. The lipophilicities were in agreement with the length of the chains. While both 99mTccomplexes showed uptake in the myocardial muscle, the designed radiopharmaceutical with the longest chain length had preferential target-uptake and target-retention compared to other complexes described in the bibliography. Further studies, involving imaging assays, synthetic modifications, and assay of new coligands for 99mTc-HYNIC complexes, are currently ongoing.Universidade de São PauloGonzález Joel, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares.García María Fernanda, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares.Cabral González Pablo, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares.Calzada Victoria, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares.Cerecetto Hugo, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares.2025-06-11T18:00:57Z2025-06-11T18:00:57Z2024Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion13 happlication/pdfGonzález, J, García, M, Cabral González, P [y otros autores]. "Design and development of 6-hydrazinonicotinylfatty acid-mimetic 99mTc-complex as a potential myocardial imaging agent". Brazilian Journal of Pharmaceutical Sciences. [en línea] 2024, 60: e23542. 13 h. DOI: 10.1590/s2175-97902024e235422175-9790https://hdl.handle.net/20.500.12008/5028710.1590/s2175-97902024e23542reponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaenengBrazilian Journal of Pharmaceutical Sciences, 2024, 60: e23542.Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC - By 4.0)oai:colibri.udelar.edu.uy:20.500.12008/502872026-04-14T10:10:52Z |
| spellingShingle | Design and development of 6-hydrazinonicotinylfatty acid-mimetic 99mTc-complex as a potential myocardial imaging agent González, Joel Technetium Radiopharmaceutical Myocardial metabolism Long chain amide |
| status_str | publishedVersion |
| title | Design and development of 6-hydrazinonicotinylfatty acid-mimetic 99mTc-complex as a potential myocardial imaging agent |
| title_full | Design and development of 6-hydrazinonicotinylfatty acid-mimetic 99mTc-complex as a potential myocardial imaging agent |
| title_fullStr | Design and development of 6-hydrazinonicotinylfatty acid-mimetic 99mTc-complex as a potential myocardial imaging agent |
| title_full_unstemmed | Design and development of 6-hydrazinonicotinylfatty acid-mimetic 99mTc-complex as a potential myocardial imaging agent |
| title_short | Design and development of 6-hydrazinonicotinylfatty acid-mimetic 99mTc-complex as a potential myocardial imaging agent |
| title_sort | Design and development of 6-hydrazinonicotinylfatty acid-mimetic 99mTc-complex as a potential myocardial imaging agent |
| topic | Technetium Radiopharmaceutical Myocardial metabolism Long chain amide |
| url | https://hdl.handle.net/20.500.12008/50287 |