A recessive Trim2 mutation causes an axonal neuropathy in mice

We analyzed Trim2A/A mice, generated by CRISPR-Cas9, which have a recessive, null mutation of Trim2. Trim2A/ A mice develop ataxia that is associated with a severe loss of cerebellar Purkinje cells and a peripheral neuro-pathy. Myelinated axons in the CNS, including those in the deep cerebellar nucl...

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Bibliographic Details

Main Author:	Jian, J. L. (author)
Other Authors:	Sarute, Nicolás (author), Lancaster, E. (author), Otkiran-Clare, G. (author), Medegan Fagla, B. (author), Ross, S. R. (author), Scherer, S. S. (author)
Format:	article
Language:	English
Published:	2020
Subjects:	Cerebellum Axonal spheroids Ataxia Axonal degeneration Charcot-Marie-tooth disease CMT
Online Access:	https://hdl.handle.net/20.500.12008/30869
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