A recessive Trim2 mutation causes an axonal neuropathy in mice
We analyzed Trim2A/A mice, generated by CRISPR-Cas9, which have a recessive, null mutation of Trim2. Trim2A/ A mice develop ataxia that is associated with a severe loss of cerebellar Purkinje cells and a peripheral neuro-pathy. Myelinated axons in the CNS, including those in the deep cerebellar nucl...
Saved in:
| 主要作者: | |
|---|---|
| 其他作者: | , , , , , |
| 格式: | article |
| 語言: | 英语 |
| 出版: |
2020
|
| 主題: | |
| 在線閱讀: | https://hdl.handle.net/20.500.12008/30869 |
| 標簽: |
沒有標簽, 成為第一個標記此記錄!
|
相似書籍: A recessive Trim2 mutation causes an axonal neuropathy in mice
- Central alteration in peripheral neuropathy of Trembler-J mice: hippocampal pmp22 expression and behavioral profile in anxiety tests
- Axon micro-dissection and transcriptome profiling reveals the in vivo RNA content of fully differentiated myelinated motor axons
- Curcumina como modulador de la proteostasis y su impacto terapéutico en Trembler-J, modelo murino de CMT1E
- PDCD4 regulates axonal growth by translational repression of neurite growth-related genes and is modulated during nerve injury responses
- Degenerative axonopathy associated with copper deficiency in pigs. (Axonopatia degenerativa associada com deficiência de cobre em suínos).
- Estudio sobre los mecanismos de regulación de la síntesis local de proteínas en axones periféricos