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Chikungunya virus vaccine candidates with decreased mutational robustness are attenuated in vivo and have compromised transmissibility

Chikungunya virus (CHIKV) is a reemerged arbovirus, a member of the Togaviridae family. It circulates through mosquito vectors mainly of the Aedes family and a mammalian host. CHIKV causes chikungunya fever, a mild to severe disease characterized by arthralgia, with some fatal outcomes described. In...

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Main Author: Carrau Eguía, Lucía (author)
Other Authors: Rezelj, V. (author), Noval, M. (author), Levi, L. (author), Megrian, Daniela (author), Blanc, H. (author), Weger-Lucarelli, J. (author), Moratorio, Gonzalo (author), Stapleford, K. (author), Vignuzzi, Marco (author)
Format: article
Language:English
Published: 2019
Subjects:
Chikungunya
Mutational robustness
Vaccines
Online Access:https://hdl.handle.net/20.500.12008/27807
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https://hdl.handle.net/20.500.12008/27807

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