Quantitative comparison between single-photon emission computed tomography and positron emission tomography imaging of lung ventilation with 99mTc-technegas and 68Ga‑gallgas in patients with chronic obstructive pulmonary disease: a pilot study
The aim of this study was quantitative comparison between 68Ga‑Gallgas positron emission tomography (PET) and 99mTc‑Technegas single photon emission computed tomography (SPECT) for lung ventilation function assessment in patients with moderate‑to‑severe obstructive pulmonary disease and to identify...
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| Format: | article |
| Language: | English |
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2019
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| Online Access: | https://hdl.handle.net/20.500.12008/30285 |
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| _version_ | 1868890043889745920 |
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| author | Cuña Rodríguez, Enrique Gustavo |
| author2 | Gambini, Juan Pablo Servente, Liliana Savio, Eduardo Engler, Henry William González Sprinberg, Gabriel A. Alonso, Omar |
| author2_role | author author author author author author |
| author_browse | Alonso, Omar Cuña Rodríguez, Enrique Gustavo Engler, Henry William Gambini, Juan Pablo González Sprinberg, Gabriel A. Savio, Eduardo Servente, Liliana |
| author_facet | Cuña Rodríguez, Enrique Gustavo Gambini, Juan Pablo Servente, Liliana Savio, Eduardo Engler, Henry William González Sprinberg, Gabriel A. Alonso, Omar |
| author_role | author |
| collection | COLIBRI |
| dc.contributor.none.fl_str_mv | Cuña Rodríguez Enrique Gustavo, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Física Gambini Juan Pablo, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Física Servente Liliana, CUDIM (Uruguay) Savio Eduardo, CUDIM (Uruguay) Engler Henry William, CUDIM (Uruguay) González Sprinberg Gabriel A., Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Física Alonso Omar, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Física |
| dc.creator.none.fl_str_mv | Cuña Rodríguez, Enrique Gustavo Gambini, Juan Pablo Servente, Liliana Savio, Eduardo Engler, Henry William González Sprinberg, Gabriel A. Alonso, Omar |
| dc.date.none.fl_str_mv | 2019 2021-12-02T18:26:48Z 2021-12-02T18:26:48Z |
| dc.format.none.fl_str_mv | 7 h. application/pdf |
| dc.identifier.none.fl_str_mv | Cuña Rodríguez, E, Gambini, J, Servente, L, [y otros] "Quantitative comparison between single-photon emission computed tomography and positron emission tomography imaging of lung ventilation with 99mTc-technegas and 68Ga‑gallgas in patients with chronic obstructive pulmonary disease: A pilot study". World Journal of Nuclear Medicine. [en línea] 2019, 18(3): 251-257. 7 h. DOI: 10.4103/wjnm.WJNM_45_18 1607-3312 https://hdl.handle.net/20.500.12008/30285 10.4103/wjnm.WJNM_45_18 |
| dc.language.none.fl_str_mv | en eng |
| dc.publisher.none.fl_str_mv | Wolters Kluwer - Medknow |
| dc.relation.none.fl_str_mv | World Journal of Nuclear Medicine, 2019, 18(3): 251-257 |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess Licencia Creative Commons Atribución (CC - By 4.0) |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.none.fl_str_mv | Gallgas Quantification Technegas Texture features |
| dc.title.none.fl_str_mv | Quantitative comparison between single-photon emission computed tomography and positron emission tomography imaging of lung ventilation with 99mTc-technegas and 68Ga‑gallgas in patients with chronic obstructive pulmonary disease: a pilot study |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | The aim of this study was quantitative comparison between 68Ga‑Gallgas positron emission tomography (PET) and 99mTc‑Technegas single photon emission computed tomography (SPECT) for lung ventilation function assessment in patients with moderate‑to‑severe obstructive pulmonary disease and to identify image‑derived texture features correlating to the physiologic parameters. Five patients with moderate‑to‑severe chronic obstructive pulmonary disease with PET and SPECT lung ventilation scans were selected for this study. Threshold‑based segmentations were used to compare ventilated regions between both imaging techniques. Histograms of both scans were compared to reveal main differences in distributions of radiotracers. Volumes of segmentation as well as 50 textural features measured in the pulmonary region were correlated to the forced expiratory volume in 1 s (FEV1) as the relevant physiological variable. A better peripheral distribution of the radiotracer was observed in PET scans for three out of five patients. A segmentation threshold of 27% and 31% for normalized scans, for PET and SPECT respectively, was found optimal for volume correlation with FEV1. A high correlation (Pearson correlation coefficient >0.9) was found between 16 texture features measured from SPECT and 7 features measured from PET and FEV1. Quantitative measurements revealed different tracer distribution in both techniques. These results suggest that tracer distribution patterns may depend on the cause of the pulmonary obstruction. We found several texture features measured from SPECT to correlate to FEV1. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_4e3cc2eb3060174c827e5af09f218302 |
| identifier_str_mv | Cuña Rodríguez, E, Gambini, J, Servente, L, [y otros] "Quantitative comparison between single-photon emission computed tomography and positron emission tomography imaging of lung ventilation with 99mTc-technegas and 68Ga‑gallgas in patients with chronic obstructive pulmonary disease: A pilot study". World Journal of Nuclear Medicine. [en línea] 2019, 18(3): 251-257. 7 h. DOI: 10.4103/wjnm.WJNM_45_18 1607-3312 10.4103/wjnm.WJNM_45_18 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/30285 |
| publishDate | 2019 |
| publishDateSort | 2019 |
| publisher.none.fl_str_mv | Wolters Kluwer - Medknow |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| spelling | Quantitative comparison between single-photon emission computed tomography and positron emission tomography imaging of lung ventilation with 99mTc-technegas and 68Ga‑gallgas in patients with chronic obstructive pulmonary disease: a pilot studyCuña Rodríguez, Enrique GustavoGambini, Juan PabloServente, LilianaSavio, EduardoEngler, Henry WilliamGonzález Sprinberg, Gabriel A.Alonso, OmarGallgasQuantificationTechnegasTexture featuresThe aim of this study was quantitative comparison between 68Ga‑Gallgas positron emission tomography (PET) and 99mTc‑Technegas single photon emission computed tomography (SPECT) for lung ventilation function assessment in patients with moderate‑to‑severe obstructive pulmonary disease and to identify image‑derived texture features correlating to the physiologic parameters. Five patients with moderate‑to‑severe chronic obstructive pulmonary disease with PET and SPECT lung ventilation scans were selected for this study. Threshold‑based segmentations were used to compare ventilated regions between both imaging techniques. Histograms of both scans were compared to reveal main differences in distributions of radiotracers. Volumes of segmentation as well as 50 textural features measured in the pulmonary region were correlated to the forced expiratory volume in 1 s (FEV1) as the relevant physiological variable. A better peripheral distribution of the radiotracer was observed in PET scans for three out of five patients. A segmentation threshold of 27% and 31% for normalized scans, for PET and SPECT respectively, was found optimal for volume correlation with FEV1. A high correlation (Pearson correlation coefficient >0.9) was found between 16 texture features measured from SPECT and 7 features measured from PET and FEV1. Quantitative measurements revealed different tracer distribution in both techniques. These results suggest that tracer distribution patterns may depend on the cause of the pulmonary obstruction. We found several texture features measured from SPECT to correlate to FEV1.Wolters Kluwer - MedknowCuña Rodríguez Enrique Gustavo, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de FísicaGambini Juan Pablo, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de FísicaServente Liliana, CUDIM (Uruguay)Savio Eduardo, CUDIM (Uruguay)Engler Henry William, CUDIM (Uruguay)González Sprinberg Gabriel A., Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de FísicaAlonso Omar, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Física2021-12-02T18:26:48Z2021-12-02T18:26:48Z2019Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion7 h.application/pdfCuña Rodríguez, E, Gambini, J, Servente, L, [y otros] "Quantitative comparison between single-photon emission computed tomography and positron emission tomography imaging of lung ventilation with 99mTc-technegas and 68Ga‑gallgas in patients with chronic obstructive pulmonary disease: A pilot study". World Journal of Nuclear Medicine. [en línea] 2019, 18(3): 251-257. 7 h. DOI: 10.4103/wjnm.WJNM_45_181607-3312https://hdl.handle.net/20.500.12008/3028510.4103/wjnm.WJNM_45_18reponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaenengWorld Journal of Nuclear Medicine, 2019, 18(3): 251-257Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC - By 4.0)oai:colibri.udelar.edu.uy:20.500.12008/302852026-04-14T10:09:43Z |
| spellingShingle | Quantitative comparison between single-photon emission computed tomography and positron emission tomography imaging of lung ventilation with 99mTc-technegas and 68Ga‑gallgas in patients with chronic obstructive pulmonary disease: a pilot study Cuña Rodríguez, Enrique Gustavo Gallgas Quantification Technegas Texture features |
| status_str | publishedVersion |
| title | Quantitative comparison between single-photon emission computed tomography and positron emission tomography imaging of lung ventilation with 99mTc-technegas and 68Ga‑gallgas in patients with chronic obstructive pulmonary disease: a pilot study |
| title_full | Quantitative comparison between single-photon emission computed tomography and positron emission tomography imaging of lung ventilation with 99mTc-technegas and 68Ga‑gallgas in patients with chronic obstructive pulmonary disease: a pilot study |
| title_fullStr | Quantitative comparison between single-photon emission computed tomography and positron emission tomography imaging of lung ventilation with 99mTc-technegas and 68Ga‑gallgas in patients with chronic obstructive pulmonary disease: a pilot study |
| title_full_unstemmed | Quantitative comparison between single-photon emission computed tomography and positron emission tomography imaging of lung ventilation with 99mTc-technegas and 68Ga‑gallgas in patients with chronic obstructive pulmonary disease: a pilot study |
| title_short | Quantitative comparison between single-photon emission computed tomography and positron emission tomography imaging of lung ventilation with 99mTc-technegas and 68Ga‑gallgas in patients with chronic obstructive pulmonary disease: a pilot study |
| title_sort | Quantitative comparison between single-photon emission computed tomography and positron emission tomography imaging of lung ventilation with 99mTc-technegas and 68Ga‑gallgas in patients with chronic obstructive pulmonary disease: a pilot study |
| topic | Gallgas Quantification Technegas Texture features |
| url | https://hdl.handle.net/20.500.12008/30285 |