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Mitochondrial morphology in fertile and infertile men : Image processing and morphometric analysis of the sperm midpiece

The male factor is responsible for 50% of infertility cases. Numerous studies have explored the relationship between human sperm morphology assessed via optical and electron microscopy and reproductive outcomes. In the sperm midpiece, mitochondria are arranged in a helical shape, forming a compact s...

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Hlavní autor: Skowronek, María Fernanda (author)
Další autoři: Pietroroia, Santiago (author), De Cola, Gabriel (author), Ramos, Mauricio (author), Silvera Coeff, Diego (author), Casanova, Gabriela (author), Lecumberry, Federico (author), Cassina, Adriana (author), Sapiro, Rossana (author)
Médium: article
Jazyk:angličtina
Vydáno: 2025
Témata:
Human infertility
Sperm midpiece
Sperm mitochondria
Fluorescent probes
Electron microscopy
Image processing
On-line přístup:https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2025.1609081/full
https://hdl.handle.net/20.500.12008/52729
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Shrnutí:The male factor is responsible for 50% of infertility cases. Numerous studies have explored the relationship between human sperm morphology assessed via optical and electron microscopy and reproductive outcomes. In the sperm midpiece, mitochondria are arranged in a helical shape, forming a compact sheath. Disruptions in this precise mitochondrial structure, size, or organization may contribute to infertility. However, despite established links between abnormal sperm morphology and pathology, mitochondrial abnormalities in sperm remain relatively understudied.

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