Oxidants and antioxidants in the redox biochemistry of human red blood cells
Red blood cells (RBCs) are exposed to both external and internal sources of oxidants that challenge their integrity and compromise their physiological function and supply of oxygen to tissues. Autoxidation of oxyhemoglobin is the main source of endogenous RBC oxidant production, yielding superoxide...
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| Format: | article |
| Language: | English |
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2023
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| Online Access: | https://hdl.handle.net/20.500.12008/43332 |
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| _version_ | 1868890253381599232 |
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| author | Möller, Matías N. |
| author2 | Orrico, Florencia Villar, Sebastián F. López Royes, Ana Clara Silva Sallúa, Nicolás Donzé Santos, Marcel Eduardo Thomson, Leonor Denicola, Ana |
| author2_role | author author author author author author author |
| author_browse | Denicola, Ana Donzé Santos, Marcel Eduardo López Royes, Ana Clara Möller, Matías N. Orrico, Florencia Silva Sallúa, Nicolás Thomson, Leonor Villar, Sebastián F. |
| author_facet | Möller, Matías N. Orrico, Florencia Villar, Sebastián F. López Royes, Ana Clara Silva Sallúa, Nicolás Donzé Santos, Marcel Eduardo Thomson, Leonor Denicola, Ana |
| author_role | author |
| collection | COLIBRI |
| dc.contributor.none.fl_str_mv | Möller Matías N., Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica. Orrico Florencia, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica. Villar Sebastián F., Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica. López Royes Ana Clara, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica. Silva Sallúa Nicolás, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica. Donzé Santos Marcel Eduardo, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica. Thomson Leonor, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica. Denicola Ana, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica. |
| dc.creator.none.fl_str_mv | Möller, Matías N. Orrico, Florencia Villar, Sebastián F. López Royes, Ana Clara Silva Sallúa, Nicolás Donzé Santos, Marcel Eduardo Thomson, Leonor Denicola, Ana |
| dc.date.none.fl_str_mv | 2023 2024-04-04T13:29:53Z 2024-04-04T13:29:53Z |
| dc.format.none.fl_str_mv | 22 h. application/pdf |
| dc.identifier.none.fl_str_mv | Möller, M, Orrico, F, Villar, S [y otros autores]. "Oxidants and antioxidants in the redox biochemistry of human red blood cells". ACS Omega. [en línea] 2023, 8(1): 147-168. 22 h. DOI: 10.1021/acsomega.2c06768. 2470-1343 https://hdl.handle.net/20.500.12008/43332 10.1021/acsomega.2c06768 |
| dc.language.none.fl_str_mv | en eng |
| dc.publisher.none.fl_str_mv | ACS Publications |
| dc.relation.none.fl_str_mv | ACS Omega, 2023, 8(1): 147-168. |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess Licencia Creative Commons Atribución (CC - By 4.0) |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.none.fl_str_mv | Antioxidants Membranes Molecules Peptides and proteins Redox reactions |
| dc.title.none.fl_str_mv | Oxidants and antioxidants in the redox biochemistry of human red blood cells |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Red blood cells (RBCs) are exposed to both external and internal sources of oxidants that challenge their integrity and compromise their physiological function and supply of oxygen to tissues. Autoxidation of oxyhemoglobin is the main source of endogenous RBC oxidant production, yielding superoxide radical and then hydrogen peroxide. In addition, potent oxidants from other blood cells and the surrounding endothelium can reach the RBCs. Abundant and efficient enzymatic systems and low molecular weight antioxidants prevent most of the damage to the RBCs and also position the RBCs as a sink of vascular oxidants that allow the body to maintain a healthy circulatory system. Among the antioxidant enzymes, the thiol-dependent peroxidase peroxiredoxin 2, highly abundant in RBCs, is essential to keep the redox balance. A great part of the RBC antioxidant activity is supported by an active glucose metabolism that provides reducing power in the form of NADPH via the pentose phosphate pathway. There are several RBC defects and situations that generate oxidative stress conditions where the defense mechanisms are overwhelmed, and these include glucose-6-phosphate dehydrogenase deficiencies (favism), hemoglobinopathies like sickle cell disease and thalassemia, as well as packed RBCs for transfusion that suffer from storage lesions. These oxidative stress-associated pathologies of the RBCs underline the relevance of redox balance in these anucleated cells that lack a mechanism of DNA-inducible antioxidant response and rely on a complex and robust network of antioxidant systems. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_ffd1f5d87d2cdbf6cd5ae19477b840a7 |
| identifier_str_mv | Möller, M, Orrico, F, Villar, S [y otros autores]. "Oxidants and antioxidants in the redox biochemistry of human red blood cells". ACS Omega. [en línea] 2023, 8(1): 147-168. 22 h. DOI: 10.1021/acsomega.2c06768. 2470-1343 10.1021/acsomega.2c06768 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/43332 |
| publishDate | 2023 |
| publishDateSort | 2023 |
| publisher.none.fl_str_mv | ACS Publications |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| spelling | Oxidants and antioxidants in the redox biochemistry of human red blood cellsMöller, Matías N.Orrico, FlorenciaVillar, Sebastián F.López Royes, Ana ClaraSilva Sallúa, NicolásDonzé Santos, Marcel EduardoThomson, LeonorDenicola, AnaAntioxidantsMembranesMoleculesPeptides and proteinsRedox reactionsRed blood cells (RBCs) are exposed to both external and internal sources of oxidants that challenge their integrity and compromise their physiological function and supply of oxygen to tissues. Autoxidation of oxyhemoglobin is the main source of endogenous RBC oxidant production, yielding superoxide radical and then hydrogen peroxide. In addition, potent oxidants from other blood cells and the surrounding endothelium can reach the RBCs. Abundant and efficient enzymatic systems and low molecular weight antioxidants prevent most of the damage to the RBCs and also position the RBCs as a sink of vascular oxidants that allow the body to maintain a healthy circulatory system. Among the antioxidant enzymes, the thiol-dependent peroxidase peroxiredoxin 2, highly abundant in RBCs, is essential to keep the redox balance. A great part of the RBC antioxidant activity is supported by an active glucose metabolism that provides reducing power in the form of NADPH via the pentose phosphate pathway. There are several RBC defects and situations that generate oxidative stress conditions where the defense mechanisms are overwhelmed, and these include glucose-6-phosphate dehydrogenase deficiencies (favism), hemoglobinopathies like sickle cell disease and thalassemia, as well as packed RBCs for transfusion that suffer from storage lesions. These oxidative stress-associated pathologies of the RBCs underline the relevance of redox balance in these anucleated cells that lack a mechanism of DNA-inducible antioxidant response and rely on a complex and robust network of antioxidant systems.CSIC: I+D_2020_46725ANII: FMV_1_2019_1_155597ACS PublicationsMöller Matías N., Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica.Orrico Florencia, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica.Villar Sebastián F., Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica.López Royes Ana Clara, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica.Silva Sallúa Nicolás, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica.Donzé Santos Marcel Eduardo, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica.Thomson Leonor, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica.Denicola Ana, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica.2024-04-04T13:29:53Z2024-04-04T13:29:53Z2023Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion22 h.application/pdfMöller, M, Orrico, F, Villar, S [y otros autores]. "Oxidants and antioxidants in the redox biochemistry of human red blood cells". ACS Omega. [en línea] 2023, 8(1): 147-168. 22 h. DOI: 10.1021/acsomega.2c06768.2470-1343https://hdl.handle.net/20.500.12008/4333210.1021/acsomega.2c06768reponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaenengACS Omega, 2023, 8(1): 147-168.Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC - By 4.0)oai:colibri.udelar.edu.uy:20.500.12008/433322026-04-14T10:10:37Z |
| spellingShingle | Oxidants and antioxidants in the redox biochemistry of human red blood cells Möller, Matías N. Antioxidants Membranes Molecules Peptides and proteins Redox reactions |
| status_str | publishedVersion |
| title | Oxidants and antioxidants in the redox biochemistry of human red blood cells |
| title_full | Oxidants and antioxidants in the redox biochemistry of human red blood cells |
| title_fullStr | Oxidants and antioxidants in the redox biochemistry of human red blood cells |
| title_full_unstemmed | Oxidants and antioxidants in the redox biochemistry of human red blood cells |
| title_short | Oxidants and antioxidants in the redox biochemistry of human red blood cells |
| title_sort | Oxidants and antioxidants in the redox biochemistry of human red blood cells |
| topic | Antioxidants Membranes Molecules Peptides and proteins Redox reactions |
| url | https://hdl.handle.net/20.500.12008/43332 |