The anolis lizard genome: an amniote genome without isochores?
Two articles published 5 years ago concluded that the genome of the lizard Anolis carolinensis is an amniote genome without isochores. This claim was apparently contradicting previous results on the general presence of an isochore organization in all vertebrate genomes tested (including Anolis). In...
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| Otros Autores: | , , |
| Formato: | article |
| Lenguaje: | inglés |
| Publicado: |
2016
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| Acceso en línea: | https://hdl.handle.net/20.500.12008/22056 |
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| _version_ | 1868890242384134144 |
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| author | Costantini, M. |
| author2 | Greif, Gonzalo Álvarez-Valín, Fernando Bernardi, Giorgio |
| author2_role | author author author |
| author_browse | Bernardi, Giorgio Costantini, M. Greif, Gonzalo Álvarez-Valín, Fernando |
| author_facet | Costantini, M. Greif, Gonzalo Álvarez-Valín, Fernando Bernardi, Giorgio |
| author_role | author |
| collection | COLIBRI |
| dc.contributor.none.fl_str_mv | Greif, Gonzalo. Instituto Pasteur (Montevideo) Alvarez-Valín, Fernando. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología |
| dc.creator.none.fl_str_mv | Costantini, M. Greif, Gonzalo Álvarez-Valín, Fernando Bernardi, Giorgio |
| dc.date.none.fl_str_mv | 2016 2019-10-02T22:12:06Z 2019-10-02T22:12:06Z 20190930 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Costantini, M. y otros. "The anolis lizard genome: an amniote genome without isochores?". Genome Biology and Evolution, 2016, 8 (4): 1048-1055. doi: 10.1093/gbe/evw056 1759-6653 https://hdl.handle.net/20.500.12008/22056 10.1093/gbe/evw056 |
| dc.language.none.fl_str_mv | en eng |
| dc.publisher.none.fl_str_mv | Oxford University Press |
| dc.relation.none.fl_str_mv | Genome Biology and Evolution, 2016, 8 (4): 1048-1055 |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess Licencia Creative Commons Atribución – No Comercial (CC-BY-NC- 4.0) |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.none.fl_str_mv | Evolution Genome structure Isochores Reptiles |
| dc.title.none.fl_str_mv | The anolis lizard genome: an amniote genome without isochores? |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Two articles published 5 years ago concluded that the genome of the lizard Anolis carolinensis is an amniote genome without isochores. This claim was apparently contradicting previous results on the general presence of an isochore organization in all vertebrate genomes tested (including Anolis). In this investigation, we demonstrate that the Anolis genome is indeed heterogeneous in base composition, since its macrochromosomes comprise isochores mainly from the L2 and H1 families (a moderately GC-poor and a moderately GC-rich family, respectively), and since the majority of the sequenced microchromosomes consists of H1 isochores. These families are associated with different features of genome structure, including gene density and compositional correlations (e.g., GC3 vs flanking sequence GC and intron GC), as in the case of mammalian and avian genomes. Moreover, the assembled Anolis chromosomes have an enormous number of gaps, which could be due to sequencing problems in GC-rich regions of the genome. In conclusion, the Anolis genome is no exception to the general rule of an isochore organization in the genomes of vertebrates (and other eukaryotes). |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_f9fd20e5ef6384d93efbcd5ffa69ae57 |
| identifier_str_mv | Costantini, M. y otros. "The anolis lizard genome: an amniote genome without isochores?". Genome Biology and Evolution, 2016, 8 (4): 1048-1055. doi: 10.1093/gbe/evw056 1759-6653 10.1093/gbe/evw056 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/22056 |
| publishDate | 2016 |
| publishDateSort | 2016 |
| publisher.none.fl_str_mv | Oxford University Press |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Licencia Creative Commons Atribución – No Comercial (CC-BY-NC- 4.0) |
| spelling | The anolis lizard genome: an amniote genome without isochores?Costantini, M.Greif, GonzaloÁlvarez-Valín, FernandoBernardi, GiorgioEvolutionGenome structureIsochoresReptilesTwo articles published 5 years ago concluded that the genome of the lizard Anolis carolinensis is an amniote genome without isochores. This claim was apparently contradicting previous results on the general presence of an isochore organization in all vertebrate genomes tested (including Anolis). In this investigation, we demonstrate that the Anolis genome is indeed heterogeneous in base composition, since its macrochromosomes comprise isochores mainly from the L2 and H1 families (a moderately GC-poor and a moderately GC-rich family, respectively), and since the majority of the sequenced microchromosomes consists of H1 isochores. These families are associated with different features of genome structure, including gene density and compositional correlations (e.g., GC3 vs flanking sequence GC and intron GC), as in the case of mammalian and avian genomes. Moreover, the assembled Anolis chromosomes have an enormous number of gaps, which could be due to sequencing problems in GC-rich regions of the genome. In conclusion, the Anolis genome is no exception to the general rule of an isochore organization in the genomes of vertebrates (and other eukaryotes).Oxford University PressGreif, Gonzalo. Instituto Pasteur (Montevideo)Alvarez-Valín, Fernando. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología2019-10-02T22:12:06Z2019-10-02T22:12:06Z201620190930Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfCostantini, M. y otros. "The anolis lizard genome: an amniote genome without isochores?". Genome Biology and Evolution, 2016, 8 (4): 1048-1055. doi: 10.1093/gbe/evw0561759-6653https://hdl.handle.net/20.500.12008/2205610.1093/gbe/evw056reponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaenengGenome Biology and Evolution, 2016, 8 (4): 1048-1055Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad De La República. (Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución – No Comercial (CC-BY-NC- 4.0)oai:colibri.udelar.edu.uy:20.500.12008/220562026-04-14T10:09:17Z |
| spellingShingle | The anolis lizard genome: an amniote genome without isochores? Costantini, M. Evolution Genome structure Isochores Reptiles |
| status_str | publishedVersion |
| title | The anolis lizard genome: an amniote genome without isochores? |
| title_full | The anolis lizard genome: an amniote genome without isochores? |
| title_fullStr | The anolis lizard genome: an amniote genome without isochores? |
| title_full_unstemmed | The anolis lizard genome: an amniote genome without isochores? |
| title_short | The anolis lizard genome: an amniote genome without isochores? |
| title_sort | The anolis lizard genome: an amniote genome without isochores? |
| topic | Evolution Genome structure Isochores Reptiles |
| url | https://hdl.handle.net/20.500.12008/22056 |