Investigating the safety of photobiomodulation in oral carcinogenesis: insights into cell proliferation, invasion, and apoptosis via the 4NQO model.
The present investigation aimed to assess the safety of photobiomodulation (PBM) on the oral carcinogenesis process induced by 4NQO, focusing on cell proliferation and apoptosis. Sixty-six Wistar rats received systemic 4NQO for 12 (n = 33) and 20 weeks (n = 33), divided into Control group, PBM 0.3 J...
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| Format: | article |
| Language: | English |
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2024
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| Online Access: | https://hdl.handle.net/20.500.12008/47143 |
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| _version_ | 1868890238293639168 |
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| author | Schuch, Lauren Frenzel |
| author2 | Campagno, Daniela Schmidt, Tuany Rafaeli Michel, Carolina Horn Troian Garcez, Tuane Nerissa Alves Velho, Vanessa Rodrigues Wagner, Vivian Petersen Castilho, Rogerio Moraes Silveira, Felipe Martins Bologna-Molina, Ronell Martins, Marco Antonio Trevizani Danilevicz, Chris Krebs Santos-Silva, Alan Roger Vargas, Pablo Agustin Martins, Manoela Domingues |
| author2_role | author author author author author author author author author author author author author author |
| author_browse | Bologna-Molina, Ronell Campagno, Daniela Castilho, Rogerio Moraes Danilevicz, Chris Krebs Garcez, Tuane Nerissa Alves Martins, Manoela Domingues Martins, Marco Antonio Trevizani Michel, Carolina Horn Troian Santos-Silva, Alan Roger Schmidt, Tuany Rafaeli Schuch, Lauren Frenzel Silveira, Felipe Martins Vargas, Pablo Agustin Velho, Vanessa Rodrigues Wagner, Vivian Petersen |
| author_facet | Schuch, Lauren Frenzel Campagno, Daniela Schmidt, Tuany Rafaeli Michel, Carolina Horn Troian Garcez, Tuane Nerissa Alves Velho, Vanessa Rodrigues Wagner, Vivian Petersen Castilho, Rogerio Moraes Silveira, Felipe Martins Bologna-Molina, Ronell Martins, Marco Antonio Trevizani Danilevicz, Chris Krebs Santos-Silva, Alan Roger Vargas, Pablo Agustin Martins, Manoela Domingues |
| author_role | author |
| collection | COLIBRI |
| dc.contributor.none.fl_str_mv | Schuch Lauren Frenzel , Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral. Campagno Daniela, Hospital de Clínicas de Porto Alegre (Brasil). Schmidt Tuany Rafaeli, Universidad Federal do Rio Grande do Sul (Brasil). Michel Carolina Horn Troian, Universidad Federal do Rio Grande do Sul (Brasil). Garcez Tuane Nerissa Alves, Hospital de Clínicas de Porto Alegre (Brasil). Velho Vanessa Rodrigues, Universidad Federal do Rio Grande do Sul (Brasil). Wagner Vivian Petersen, Universidad de São Paulo (FOUSP) (Brasil). Castilho Rogerio Moraes, Universidad de Michigan (Estados Unidos). Silveira Felipe Martins, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral. Bologna-Molina Ronell, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral. Martins Marco Antonio Trevizani, Universidad Federal do Rio Grande do Sul. Danilevicz Chris Krebs, Universidad Federal do Rio Grande do Sul Santos-Silva Alan Roger, Universidade Estadual de Campinas. Vargas Pablo Agustin, Universidad Estadual de Campinas. Martins Manoela Domingues, Universidad Estadual de Campinas. |
| dc.creator.none.fl_str_mv | Schuch, Lauren Frenzel Campagno, Daniela Schmidt, Tuany Rafaeli Michel, Carolina Horn Troian Garcez, Tuane Nerissa Alves Velho, Vanessa Rodrigues Wagner, Vivian Petersen Castilho, Rogerio Moraes Silveira, Felipe Martins Bologna-Molina, Ronell Martins, Marco Antonio Trevizani Danilevicz, Chris Krebs Santos-Silva, Alan Roger Vargas, Pablo Agustin Martins, Manoela Domingues |
| dc.date.none.fl_str_mv | 2024-11-19T16:13:03Z 2024-11-19T16:13:03Z 2024 |
| dc.format.none.fl_str_mv | 11 h. application/pdf |
| dc.identifier.none.fl_str_mv | Schuch, L, Campagno, D, Schmidt, T, [y otros autores]. "Investigating the safety of photobiomodulation in oral carcinogenesis: insights into cell proliferation, invasion, and apoptosis via the 4NQO model". Scientific Reports. [en línea] 2024,14:28303. 11 h. 2045-2322 https://hdl.handle.net/20.500.12008/47143 10.1038/s41598-024-78763-y |
| dc.language.none.fl_str_mv | en_US eng |
| dc.publisher.none.fl_str_mv | Springer Nature |
| dc.relation.none.fl_str_mv | Scientific Reports, 2024,14:28303. |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.none.fl_str_mv | Cancer oral Carciogénesis Terapia de fotobiomodulación NEOPLASIAS DE LA BOCA LEUCOPLASIA TERAPIA POR LUZ DE BAJA INTENSIDAD TERAPIA POR LASER |
| dc.title.none.fl_str_mv | Investigating the safety of photobiomodulation in oral carcinogenesis: insights into cell proliferation, invasion, and apoptosis via the 4NQO model. |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | The present investigation aimed to assess the safety of photobiomodulation (PBM) on the oral carcinogenesis process induced by 4NQO, focusing on cell proliferation and apoptosis. Sixty-six Wistar rats received systemic 4NQO for 12 (n = 33) and 20 weeks (n = 33), divided into Control group, PBM 0.3 J, and PBM 1 J. Applications for PBM occurred three times a week. At weeks 12 and 20, the animals were euthanized. The immunoreactivity for anti-ROS1 and anti-p53 antibodies was also assessed. Statistical analysis was assessed by multiple t-tests, Kruskal-Wallis, and Spearman’s correlation. At 12 weeks, PBM 1 J group had nodular lesions, distinct from control and PBM 0.3 J groups (p = 0.005). At 20 weeks, nodular lesions were common in control and PBM 0.3 J groups. Histopathological characteristics did not significantly differ between groups at 12 (p = 0.30) and 20 weeks (p = 0.58). Epithelial dysplasia (n = 21) was common at 12 weeks. After 20 weeks, most of the cases revealed squamous cell carcinoma (n = 24). No differences were observed in the immunostaining of p53 and ROS1 among the control and experimental groups and there was no correlation of these proteins with clinicopathological data. During the carcinogenesis process, the PBM did not modify the development of oral lesions and the expression of proliferative and apoptosis proteins. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_f75a8b3c19d567b4634fcee04062bd02 |
| identifier_str_mv | Schuch, L, Campagno, D, Schmidt, T, [y otros autores]. "Investigating the safety of photobiomodulation in oral carcinogenesis: insights into cell proliferation, invasion, and apoptosis via the 4NQO model". Scientific Reports. [en línea] 2024,14:28303. 11 h. 2045-2322 10.1038/s41598-024-78763-y |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en_US |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/47143 |
| publishDate | 2024 |
| publishDateSort | 2024 |
| publisher.none.fl_str_mv | Springer Nature |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
| spelling | Investigating the safety of photobiomodulation in oral carcinogenesis: insights into cell proliferation, invasion, and apoptosis via the 4NQO model.Schuch, Lauren FrenzelCampagno, DanielaSchmidt, Tuany RafaeliMichel, Carolina Horn TroianGarcez, Tuane Nerissa AlvesVelho, Vanessa RodriguesWagner, Vivian PetersenCastilho, Rogerio MoraesSilveira, Felipe MartinsBologna-Molina, RonellMartins, Marco Antonio TrevizaniDanilevicz, Chris KrebsSantos-Silva, Alan RogerVargas, Pablo AgustinMartins, Manoela DominguesCancer oralCarciogénesisTerapia de fotobiomodulaciónNEOPLASIAS DE LA BOCALEUCOPLASIATERAPIA POR LUZ DE BAJA INTENSIDADTERAPIA POR LASERThe present investigation aimed to assess the safety of photobiomodulation (PBM) on the oral carcinogenesis process induced by 4NQO, focusing on cell proliferation and apoptosis. Sixty-six Wistar rats received systemic 4NQO for 12 (n = 33) and 20 weeks (n = 33), divided into Control group, PBM 0.3 J, and PBM 1 J. Applications for PBM occurred three times a week. At weeks 12 and 20, the animals were euthanized. The immunoreactivity for anti-ROS1 and anti-p53 antibodies was also assessed. Statistical analysis was assessed by multiple t-tests, Kruskal-Wallis, and Spearman’s correlation. At 12 weeks, PBM 1 J group had nodular lesions, distinct from control and PBM 0.3 J groups (p = 0.005). At 20 weeks, nodular lesions were common in control and PBM 0.3 J groups. Histopathological characteristics did not significantly differ between groups at 12 (p = 0.30) and 20 weeks (p = 0.58). Epithelial dysplasia (n = 21) was common at 12 weeks. After 20 weeks, most of the cases revealed squamous cell carcinoma (n = 24). No differences were observed in the immunostaining of p53 and ROS1 among the control and experimental groups and there was no correlation of these proteins with clinicopathological data. During the carcinogenesis process, the PBM did not modify the development of oral lesions and the expression of proliferative and apoptosis proteins.Springer NatureSchuch Lauren Frenzel , Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.Campagno Daniela, Hospital de Clínicas de Porto Alegre (Brasil).Schmidt Tuany Rafaeli, Universidad Federal do Rio Grande do Sul (Brasil).Michel Carolina Horn Troian, Universidad Federal do Rio Grande do Sul (Brasil).Garcez Tuane Nerissa Alves, Hospital de Clínicas de Porto Alegre (Brasil).Velho Vanessa Rodrigues, Universidad Federal do Rio Grande do Sul (Brasil).Wagner Vivian Petersen, Universidad de São Paulo (FOUSP) (Brasil).Castilho Rogerio Moraes, Universidad de Michigan (Estados Unidos).Silveira Felipe Martins, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.Bologna-Molina Ronell, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.Martins Marco Antonio Trevizani, Universidad Federal do Rio Grande do Sul.Danilevicz Chris Krebs, Universidad Federal do Rio Grande do SulSantos-Silva Alan Roger, Universidade Estadual de Campinas.Vargas Pablo Agustin, Universidad Estadual de Campinas.Martins Manoela Domingues, Universidad Estadual de Campinas.2024-11-19T16:13:03Z2024-11-19T16:13:03Z2024Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion11 h.application/pdfSchuch, L, Campagno, D, Schmidt, T, [y otros autores]. "Investigating the safety of photobiomodulation in oral carcinogenesis: insights into cell proliferation, invasion, and apoptosis via the 4NQO model". Scientific Reports. [en línea] 2024,14:28303. 11 h.2045-2322https://hdl.handle.net/20.500.12008/4714310.1038/s41598-024-78763-yreponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la Repúblicaen_USengScientific Reports, 2024,14:28303.Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0)oai:colibri.udelar.edu.uy:20.500.12008/471432026-04-14T10:37:15Z |
| spellingShingle | Investigating the safety of photobiomodulation in oral carcinogenesis: insights into cell proliferation, invasion, and apoptosis via the 4NQO model. Schuch, Lauren Frenzel Cancer oral Carciogénesis Terapia de fotobiomodulación NEOPLASIAS DE LA BOCA LEUCOPLASIA TERAPIA POR LUZ DE BAJA INTENSIDAD TERAPIA POR LASER |
| status_str | publishedVersion |
| title | Investigating the safety of photobiomodulation in oral carcinogenesis: insights into cell proliferation, invasion, and apoptosis via the 4NQO model. |
| title_full | Investigating the safety of photobiomodulation in oral carcinogenesis: insights into cell proliferation, invasion, and apoptosis via the 4NQO model. |
| title_fullStr | Investigating the safety of photobiomodulation in oral carcinogenesis: insights into cell proliferation, invasion, and apoptosis via the 4NQO model. |
| title_full_unstemmed | Investigating the safety of photobiomodulation in oral carcinogenesis: insights into cell proliferation, invasion, and apoptosis via the 4NQO model. |
| title_short | Investigating the safety of photobiomodulation in oral carcinogenesis: insights into cell proliferation, invasion, and apoptosis via the 4NQO model. |
| title_sort | Investigating the safety of photobiomodulation in oral carcinogenesis: insights into cell proliferation, invasion, and apoptosis via the 4NQO model. |
| topic | Cancer oral Carciogénesis Terapia de fotobiomodulación NEOPLASIAS DE LA BOCA LEUCOPLASIA TERAPIA POR LUZ DE BAJA INTENSIDAD TERAPIA POR LASER |
| url | https://hdl.handle.net/20.500.12008/47143 |