Infammasome activation, NLRP3 engagement and macrophage recruitment to tumor microenvironment are all required for Salmonella antitumor efect

Salmonella-based cancer therapies show great potential in preclinical models, but for most cases the observed antitumor efect is transient. Understanding the basis of the antitumor efcacy might guide the design of improved strains that elicit long-lasting efects, paving the wave for clinical use. He...

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Bibliographic Details

Main Author:	Mónaco, Amy (author)
Other Authors:	Chilibroste, Sofía (author), Yim, Lucía (author), Chabalgoity, José Alejandro (author), Moreno, María (author)
Format:	article
Language:	English
Published:	2022
Subjects:	Salmonella immunotherapy Melanoma Infammasome Macrophage recruitment M2/M1 shift
Online Access:	https://hdl.handle.net/20.500.12008/50800
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