Sepsis caused by New Delhi metallo-b-lactamase (blaNDM-1) and qnrD-producing Morganella morganii, treated successfully with fosfomycin and meropenem: case report and literature review
Objectives: The objective of this study was to describe the microbiological characteristics of an extensively drug-resistant (XDR) isolate of Morganella morganii obtained from a patient with sepsis of urinary origin and to describe the patient’s clinical characteristics. We further aimed to perform...
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| Formato: | article |
| Idioma: | inglês |
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2015
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| Acesso em linha: | https://hdl.handle.net/20.500.12008/50706 |
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| _version_ | 1868890235152105472 |
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| author | Seija, Verónica |
| author2 | Medina Presentado, Julio César Bado, Inés Papa Ezdra, Romina Batista, Noelia Gutierrez, Claudia Guirado, Mariana Vidal, Macarena Nin, Marcelo Vignoli, Rafael |
| author2_role | author author author author author author author author author |
| author_browse | Bado, Inés Batista, Noelia Guirado, Mariana Gutierrez, Claudia Medina Presentado, Julio César Nin, Marcelo Papa Ezdra, Romina Seija, Verónica Vidal, Macarena Vignoli, Rafael |
| author_facet | Seija, Verónica Medina Presentado, Julio César Bado, Inés Papa Ezdra, Romina Batista, Noelia Gutierrez, Claudia Guirado, Mariana Vidal, Macarena Nin, Marcelo Vignoli, Rafael |
| author_role | author |
| collection | COLIBRI |
| dc.contributor.none.fl_str_mv | Seija Verónica, Universidad de la República (Uruguay). Facultad de Medicina. Hospital de Clínicas. Área Microbiología. Unidad Académica Laboratorio Clínico Medina Presentado Julio César, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Cátedra de Enfermedades Infecciosas Bado Inés, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Bacteriología y Virología Papa Ezdra Romina, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Bacteriología y Virología Batista Noelia, Universidad de la República (Uruguay). Facultad de Medicina. Hospital de Clínicas. Área Microbiología. Unidad Académica Laboratorio Clínico Gutierrez Claudia, Universidad de la República (Uruguay). Facultad de Medicina. Hospital de Clínicas. Área Microbiología. Unidad Académica Laboratorio Clínico Guirado Mariana, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Cátedra de Enfermedades Infecciosas Vidal Macarena, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Cátedra de Enfermedades Infecciosas Nin Marcelo, Universidad de la República (Uruguay). Facultad de Medicina. Hospital de Clínicas. Centro de Nefrología Vignoli Rafael, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Bacteriología y Virología |
| dc.creator.none.fl_str_mv | Seija, Verónica Medina Presentado, Julio César Bado, Inés Papa Ezdra, Romina Batista, Noelia Gutierrez, Claudia Guirado, Mariana Vidal, Macarena Nin, Marcelo Vignoli, Rafael |
| dc.date.none.fl_str_mv | 2015 2025-07-22T15:16:21Z 2025-07-22T15:16:21Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | SEIJA, V., MEDINA PRESENTADO, JC., BADO, I., y otros. Sepsis caused by New Delhi metallo-b-lactamase (blaNDM-1) and qnrD-producing Morganella morganii, treated successfully with fosfomycin and meropenem: case report and literature review. Int J Infect Dis [en línea] 2015, 30. DOI: 10.1016/j.ijid.2014.09.010 https://hdl.handle.net/20.500.12008/50706 10.1016/j.ijid.2014.09.010 |
| dc.language.none.fl_str_mv | en eng |
| dc.relation.none.fl_str_mv | Int J Infect Dis. 30, 2015 |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.none.fl_str_mv | NDM-1 Morganella morganii Sepsis Meropenem Fosfomycin |
| dc.title.none.fl_str_mv | Sepsis caused by New Delhi metallo-b-lactamase (blaNDM-1) and qnrD-producing Morganella morganii, treated successfully with fosfomycin and meropenem: case report and literature review |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Objectives: The objective of this study was to describe the microbiological characteristics of an extensively drug-resistant (XDR) isolate of Morganella morganii obtained from a patient with sepsis of urinary origin and to describe the patient’s clinical characteristics. We further aimed to perform a literature review of the situation in Latin America regarding Gram-negative bacillus (GNB) carriers of New Delhi metallo-b-lactamase (NDM-1) and qnr genes and current reports on the treatment of infections caused by XDR enterobacteria, with particular attention to colistin-resistant isolates. Methods: The patient’s clinical data were obtained from his medical history. Microbiological identification and susceptibility testing were done using the VITEK 2 Compact System. Resistance genes were detected by PCR and sequencing. Results: Blood and urine cultures grew an M. morganii isolate (Mm4232) harboring NDM-1 and qnrD1. The patient was treated successfully with fosfomycin and double doses of meropenem. There are no previous reports of the use of fosfomycin and meropenem to treat infections by XDR enterobacteria harboring NDM-1 carbapenemase. Conclusions: This is the first report of qnrD1 in South America. We consider that this report could be helpful to physicians implementing treatments for infections caused by XDR GNB, including colistin– carbapenem-resistant GNB. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_f583f1c1d9daa44487fb8b3d64c226f0 |
| identifier_str_mv | SEIJA, V., MEDINA PRESENTADO, JC., BADO, I., y otros. Sepsis caused by New Delhi metallo-b-lactamase (blaNDM-1) and qnrD-producing Morganella morganii, treated successfully with fosfomycin and meropenem: case report and literature review. Int J Infect Dis [en línea] 2015, 30. DOI: 10.1016/j.ijid.2014.09.010 10.1016/j.ijid.2014.09.010 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/50706 |
| publishDate | 2015 |
| publishDateSort | 2015 |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
| spelling | Sepsis caused by New Delhi metallo-b-lactamase (blaNDM-1) and qnrD-producing Morganella morganii, treated successfully with fosfomycin and meropenem: case report and literature reviewSeija, VerónicaMedina Presentado, Julio CésarBado, InésPapa Ezdra, RominaBatista, NoeliaGutierrez, ClaudiaGuirado, MarianaVidal, MacarenaNin, MarceloVignoli, RafaelNDM-1Morganella morganiiSepsisMeropenemFosfomycinObjectives: The objective of this study was to describe the microbiological characteristics of an extensively drug-resistant (XDR) isolate of Morganella morganii obtained from a patient with sepsis of urinary origin and to describe the patient’s clinical characteristics. We further aimed to perform a literature review of the situation in Latin America regarding Gram-negative bacillus (GNB) carriers of New Delhi metallo-b-lactamase (NDM-1) and qnr genes and current reports on the treatment of infections caused by XDR enterobacteria, with particular attention to colistin-resistant isolates. Methods: The patient’s clinical data were obtained from his medical history. Microbiological identification and susceptibility testing were done using the VITEK 2 Compact System. Resistance genes were detected by PCR and sequencing. Results: Blood and urine cultures grew an M. morganii isolate (Mm4232) harboring NDM-1 and qnrD1. The patient was treated successfully with fosfomycin and double doses of meropenem. There are no previous reports of the use of fosfomycin and meropenem to treat infections by XDR enterobacteria harboring NDM-1 carbapenemase. Conclusions: This is the first report of qnrD1 in South America. We consider that this report could be helpful to physicians implementing treatments for infections caused by XDR GNB, including colistin– carbapenem-resistant GNB.Comisión Sectorial de Investigación Científica (CSIC)Seija Verónica, Universidad de la República (Uruguay). Facultad de Medicina. Hospital de Clínicas. Área Microbiología. Unidad Académica Laboratorio ClínicoMedina Presentado Julio César, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Cátedra de Enfermedades InfecciosasBado Inés, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Bacteriología y VirologíaPapa Ezdra Romina, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Bacteriología y VirologíaBatista Noelia, Universidad de la República (Uruguay). Facultad de Medicina. Hospital de Clínicas. Área Microbiología. Unidad Académica Laboratorio ClínicoGutierrez Claudia, Universidad de la República (Uruguay). Facultad de Medicina. Hospital de Clínicas. Área Microbiología. Unidad Académica Laboratorio ClínicoGuirado Mariana, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Cátedra de Enfermedades InfecciosasVidal Macarena, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Cátedra de Enfermedades InfecciosasNin Marcelo, Universidad de la República (Uruguay). Facultad de Medicina. Hospital de Clínicas. Centro de NefrologíaVignoli Rafael, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Bacteriología y Virología2025-07-22T15:16:21Z2025-07-22T15:16:21Z2015Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfSEIJA, V., MEDINA PRESENTADO, JC., BADO, I., y otros. Sepsis caused by New Delhi metallo-b-lactamase (blaNDM-1) and qnrD-producing Morganella morganii, treated successfully with fosfomycin and meropenem: case report and literature review. Int J Infect Dis [en línea] 2015, 30. DOI: 10.1016/j.ijid.2014.09.010https://hdl.handle.net/20.500.12008/5070610.1016/j.ijid.2014.09.010reponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaenengInt J Infect Dis. 30, 2015Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0)oai:colibri.udelar.edu.uy:20.500.12008/507062026-04-14T10:37:01Z |
| spellingShingle | Sepsis caused by New Delhi metallo-b-lactamase (blaNDM-1) and qnrD-producing Morganella morganii, treated successfully with fosfomycin and meropenem: case report and literature review Seija, Verónica NDM-1 Morganella morganii Sepsis Meropenem Fosfomycin |
| status_str | publishedVersion |
| title | Sepsis caused by New Delhi metallo-b-lactamase (blaNDM-1) and qnrD-producing Morganella morganii, treated successfully with fosfomycin and meropenem: case report and literature review |
| title_full | Sepsis caused by New Delhi metallo-b-lactamase (blaNDM-1) and qnrD-producing Morganella morganii, treated successfully with fosfomycin and meropenem: case report and literature review |
| title_fullStr | Sepsis caused by New Delhi metallo-b-lactamase (blaNDM-1) and qnrD-producing Morganella morganii, treated successfully with fosfomycin and meropenem: case report and literature review |
| title_full_unstemmed | Sepsis caused by New Delhi metallo-b-lactamase (blaNDM-1) and qnrD-producing Morganella morganii, treated successfully with fosfomycin and meropenem: case report and literature review |
| title_short | Sepsis caused by New Delhi metallo-b-lactamase (blaNDM-1) and qnrD-producing Morganella morganii, treated successfully with fosfomycin and meropenem: case report and literature review |
| title_sort | Sepsis caused by New Delhi metallo-b-lactamase (blaNDM-1) and qnrD-producing Morganella morganii, treated successfully with fosfomycin and meropenem: case report and literature review |
| topic | NDM-1 Morganella morganii Sepsis Meropenem Fosfomycin |
| url | https://hdl.handle.net/20.500.12008/50706 |