Evidence of increasing diversification of emerging Severe Acute Respiratory Syndrome Coronavirus 2 strains
On 30th January 2020, an outbreak of atypical pneumonia caused by a novelbetacoronavirus, named severe acute respiratory syndrome coronavirus 2(SARS‐CoV‐2), was declared a public health emergency of international concern bythe World Health Organization. For this reason, a detailed evolutionary analy...
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| Other Authors: | , , |
| Format: | article |
| Language: | English |
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2020
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| Online Access: | https://hdl.handle.net/20.500.12008/30811 |
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| _version_ | 1868890233698779136 |
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| author | Castells Bauer, Matías |
| author2 | López Tort, Luis Fernando Colina, Rodney Cristina, Juan |
| author2_role | author author author |
| author_browse | Castells Bauer, Matías Colina, Rodney Cristina, Juan López Tort, Luis Fernando |
| author_facet | Castells Bauer, Matías López Tort, Luis Fernando Colina, Rodney Cristina, Juan |
| author_role | author |
| collection | COLIBRI |
| dc.contributor.none.fl_str_mv | Castells Bauer Matías, Universidad de la República (Uruguay). CENUR López Tort Luis Fernando, Universidad de la República (Uruguay). CENUR Colina Rodney, Universidad de la República (Uruguay). CENUR Cristina Juan, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares |
| dc.creator.none.fl_str_mv | Castells Bauer, Matías López Tort, Luis Fernando Colina, Rodney Cristina, Juan |
| dc.date.none.fl_str_mv | 2020 2022-02-09T13:13:42Z 2022-02-09T13:13:42Z |
| dc.format.none.fl_str_mv | 8 h. application/pdf |
| dc.identifier.none.fl_str_mv | Castells Bauer, M, López-Tort, F, Colina, R [y otros] "Evidence of increasing diversification of emerging Severe Acute Respiratory Syndrome Coronavirus 2 strains". Journal of Medical Virology. [en línea] 2020, 92: 2165–2172. 8 h. DOI: 10.1002/jmv.26018 1096-9071 https://hdl.handle.net/20.500.12008/30811 10.1002/jmv.26018 |
| dc.language.none.fl_str_mv | en eng |
| dc.publisher.none.fl_str_mv | Wiley-Liss |
| dc.relation.none.fl_str_mv | Journal of Medical Virology, 2020, 92: 2165–2172 |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess Licencia Creative Commons Atribución (CC - By 4.0) |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.none.fl_str_mv | Coalescent Coronavirus Evolution SARS‐CoV‐2 |
| dc.title.none.fl_str_mv | Evidence of increasing diversification of emerging Severe Acute Respiratory Syndrome Coronavirus 2 strains |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | On 30th January 2020, an outbreak of atypical pneumonia caused by a novelbetacoronavirus, named severe acute respiratory syndrome coronavirus 2(SARS‐CoV‐2), was declared a public health emergency of international concern bythe World Health Organization. For this reason, a detailed evolutionary analysis ofSARS‐CoV‐2 strains currently circulating in different geographic regions of theworld was performed. A compositional analysis as well as a Bayesian coalescentanalysis of complete genome sequences of SARS‐CoV‐2 strains recently isolated inEurope, North America, South America, and Asia was performed. The results ofthese studies revealed a diversification of SARS‐CoV‐2 strains in three differentgenetic clades. Co‐circulation of different clades in different countries, as well asdifferent genetic lineages within different clades were observed. The time of themost recent common ancestor was established to be around 1st November 2019.A mean rate of evolution of 6.57 × 10−4substitutions per site per year was found.A significant migration rate per genetic lineage per year from Europe to SouthAmerica was also observed. The results of these studies revealed an increasingdiversification of SARS‐CoV‐2 strains. High evolutionary rates and fast populationgrowth characterizes the population dynamics of SARS‐CoV‐2 strains. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_f46cec07e86e673cf60ececa6885e962 |
| identifier_str_mv | Castells Bauer, M, López-Tort, F, Colina, R [y otros] "Evidence of increasing diversification of emerging Severe Acute Respiratory Syndrome Coronavirus 2 strains". Journal of Medical Virology. [en línea] 2020, 92: 2165–2172. 8 h. DOI: 10.1002/jmv.26018 1096-9071 10.1002/jmv.26018 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/30811 |
| publishDate | 2020 |
| publishDateSort | 2020 |
| publisher.none.fl_str_mv | Wiley-Liss |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| spelling | Evidence of increasing diversification of emerging Severe Acute Respiratory Syndrome Coronavirus 2 strainsCastells Bauer, MatíasLópez Tort, Luis FernandoColina, RodneyCristina, JuanCoalescentCoronavirusEvolutionSARS‐CoV‐2On 30th January 2020, an outbreak of atypical pneumonia caused by a novelbetacoronavirus, named severe acute respiratory syndrome coronavirus 2(SARS‐CoV‐2), was declared a public health emergency of international concern bythe World Health Organization. For this reason, a detailed evolutionary analysis ofSARS‐CoV‐2 strains currently circulating in different geographic regions of theworld was performed. A compositional analysis as well as a Bayesian coalescentanalysis of complete genome sequences of SARS‐CoV‐2 strains recently isolated inEurope, North America, South America, and Asia was performed. The results ofthese studies revealed a diversification of SARS‐CoV‐2 strains in three differentgenetic clades. Co‐circulation of different clades in different countries, as well asdifferent genetic lineages within different clades were observed. The time of themost recent common ancestor was established to be around 1st November 2019.A mean rate of evolution of 6.57 × 10−4substitutions per site per year was found.A significant migration rate per genetic lineage per year from Europe to SouthAmerica was also observed. The results of these studies revealed an increasingdiversification of SARS‐CoV‐2 strains. High evolutionary rates and fast populationgrowth characterizes the population dynamics of SARS‐CoV‐2 strains.Wiley-LissCastells Bauer Matías, Universidad de la República (Uruguay). CENURLópez Tort Luis Fernando, Universidad de la República (Uruguay). CENURColina Rodney, Universidad de la República (Uruguay). CENURCristina Juan, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares2022-02-09T13:13:42Z2022-02-09T13:13:42Z2020Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion8 h.application/pdfCastells Bauer, M, López-Tort, F, Colina, R [y otros] "Evidence of increasing diversification of emerging Severe Acute Respiratory Syndrome Coronavirus 2 strains". Journal of Medical Virology. [en línea] 2020, 92: 2165–2172. 8 h. DOI: 10.1002/jmv.260181096-9071https://hdl.handle.net/20.500.12008/3081110.1002/jmv.26018reponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaenengJournal of Medical Virology, 2020, 92: 2165–2172Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC - By 4.0)oai:colibri.udelar.edu.uy:20.500.12008/308112026-04-14T10:09:45Z |
| spellingShingle | Evidence of increasing diversification of emerging Severe Acute Respiratory Syndrome Coronavirus 2 strains Castells Bauer, Matías Coalescent Coronavirus Evolution SARS‐CoV‐2 |
| status_str | publishedVersion |
| title | Evidence of increasing diversification of emerging Severe Acute Respiratory Syndrome Coronavirus 2 strains |
| title_full | Evidence of increasing diversification of emerging Severe Acute Respiratory Syndrome Coronavirus 2 strains |
| title_fullStr | Evidence of increasing diversification of emerging Severe Acute Respiratory Syndrome Coronavirus 2 strains |
| title_full_unstemmed | Evidence of increasing diversification of emerging Severe Acute Respiratory Syndrome Coronavirus 2 strains |
| title_short | Evidence of increasing diversification of emerging Severe Acute Respiratory Syndrome Coronavirus 2 strains |
| title_sort | Evidence of increasing diversification of emerging Severe Acute Respiratory Syndrome Coronavirus 2 strains |
| topic | Coalescent Coronavirus Evolution SARS‐CoV‐2 |
| url | https://hdl.handle.net/20.500.12008/30811 |