Granular cells in ghost cell odontogenic lesions: an unusual and unexpected finding
This study aimed to present two cases of ghost cell odontogenic lesions (GCOL) with granular cells, an unusual finding, in order to contribute to their immunohistochemical characterization and compare results with previous reports. One case corresponded to a calcifying odontogenic cyst (COC) in a 44...
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| Other Authors: | , , , , , |
| Format: | article |
| Language: | English |
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2025
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| Online Access: | https://hdl.handle.net/20.500.12008/51676 |
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| _version_ | 1868890226544345088 |
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| author | Polti, Lucas Fabian |
| author2 | Sicco, Estefanía Silveira, Felipe Martins Schuch, Lauren Frenzel Pereira-Prado, Vanesa Bologna-Molina, Ronell Paparella, María Luisa |
| author2_role | author author author author author author |
| author_browse | Bologna-Molina, Ronell Paparella, María Luisa Pereira-Prado, Vanesa Polti, Lucas Fabian Schuch, Lauren Frenzel Sicco, Estefanía Silveira, Felipe Martins |
| author_facet | Polti, Lucas Fabian Sicco, Estefanía Silveira, Felipe Martins Schuch, Lauren Frenzel Pereira-Prado, Vanesa Bologna-Molina, Ronell Paparella, María Luisa |
| author_role | author |
| collection | COLIBRI |
| dc.contributor.none.fl_str_mv | Polti Lucas Fabian, Universidad de Buenos Aires (Uruguay). Facultad de Odontología. Sicco Estefanía, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral. Silveira Felipe Martins, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral. Schuch Lauren Frenzel, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral. Pereira-Prado Vanesa, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral. Bologna-Molina Ronell, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral. Paparella María Luisa, Universidad de Buenos Aires (Uruguay). Facultad de Odontología. |
| dc.creator.none.fl_str_mv | Polti, Lucas Fabian Sicco, Estefanía Silveira, Felipe Martins Schuch, Lauren Frenzel Pereira-Prado, Vanesa Bologna-Molina, Ronell Paparella, María Luisa |
| dc.date.none.fl_str_mv | 2025-09-17T17:22:19Z 2025-09-17T17:22:19Z 2025 |
| dc.format.none.fl_str_mv | 9 h. application/pdf |
| dc.identifier.none.fl_str_mv | Polti, L, Sicco, E, Silveira, F [y otros autores]. "Granular cells in ghost cell odontogenic lesions: an unusual and unexpected finding". Journal of Oral Diagnosis. [en línea] 2025, 10:e354. 9 h. 2525-5711 https://hdl.handle.net/20.500.12008/51676 10.5327/2525-5711.34 |
| dc.language.none.fl_str_mv | en_US eng |
| dc.publisher.none.fl_str_mv | Brazilian Society of Oral Medicine and Oral Pathology (SOBEP). |
| dc.relation.none.fl_str_mv | Journal of Oral Diagnosis, 2025, 10:e354. |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess Licencia Creative Commons Atribución (CC - By 4.0) |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.none.fl_str_mv | Ghost cell Odontogenic lesions Calcifying odontogenic cyst Dentinogenic ghost cell tumor Granular cells Immunohistochemistry QUISTE ODONTOGÉNICO CALCIFICADO INMUNOHISTOQUÍMICA |
| dc.title.none.fl_str_mv | Granular cells in ghost cell odontogenic lesions: an unusual and unexpected finding |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | This study aimed to present two cases of ghost cell odontogenic lesions (GCOL) with granular cells, an unusual finding, in order to contribute to their immunohistochemical characterization and compare results with previous reports. One case corresponded to a calcifying odontogenic cyst (COC) in a 44-year-old man and the other to a dentinogenic ghost cell tumor (DGCT) presenting in an 84-year-old woman. Both lesions were located in the mandible. Microscopically, COC showed a cystic wall lined by ameloblastic/ameloblastomatous epithelium with ghost cells, and DGCT showed ameloblastomatous proliferation with ghost cells and dentinoid/osteodentin matrix. In addition, the presence of cells with abundant granular cytoplasm was observed within the epithelial lining in the cystic lesion and trapped in the dentinoid matrix in the neoplastic lesion. In both cases, the granular cells were positive for AE1-AE3, S100, and CD68; additionally, granular cells in the DGCT were positive for CK19, amelogenin, β-catenin, E-cadherin, vimentin, and lysozyme. The immunohistochemical profile suggests an epithelial origin of granular cells with an increase in lysosomes possibly associated with a degenerative process. Further studies are necessary to clarify the origin of these cells. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_ee20f237d5fedcb3d0ff5f8a45b63edc |
| identifier_str_mv | Polti, L, Sicco, E, Silveira, F [y otros autores]. "Granular cells in ghost cell odontogenic lesions: an unusual and unexpected finding". Journal of Oral Diagnosis. [en línea] 2025, 10:e354. 9 h. 2525-5711 10.5327/2525-5711.34 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en_US |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/51676 |
| publishDate | 2025 |
| publishDateSort | 2025 |
| publisher.none.fl_str_mv | Brazilian Society of Oral Medicine and Oral Pathology (SOBEP). |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| spelling | Granular cells in ghost cell odontogenic lesions: an unusual and unexpected findingPolti, Lucas FabianSicco, EstefaníaSilveira, Felipe MartinsSchuch, Lauren FrenzelPereira-Prado, VanesaBologna-Molina, RonellPaparella, María LuisaGhost cellOdontogenic lesionsCalcifying odontogenic cystDentinogenic ghost cell tumorGranular cellsImmunohistochemistryQUISTE ODONTOGÉNICO CALCIFICADOINMUNOHISTOQUÍMICAThis study aimed to present two cases of ghost cell odontogenic lesions (GCOL) with granular cells, an unusual finding, in order to contribute to their immunohistochemical characterization and compare results with previous reports. One case corresponded to a calcifying odontogenic cyst (COC) in a 44-year-old man and the other to a dentinogenic ghost cell tumor (DGCT) presenting in an 84-year-old woman. Both lesions were located in the mandible. Microscopically, COC showed a cystic wall lined by ameloblastic/ameloblastomatous epithelium with ghost cells, and DGCT showed ameloblastomatous proliferation with ghost cells and dentinoid/osteodentin matrix. In addition, the presence of cells with abundant granular cytoplasm was observed within the epithelial lining in the cystic lesion and trapped in the dentinoid matrix in the neoplastic lesion. In both cases, the granular cells were positive for AE1-AE3, S100, and CD68; additionally, granular cells in the DGCT were positive for CK19, amelogenin, β-catenin, E-cadherin, vimentin, and lysozyme. The immunohistochemical profile suggests an epithelial origin of granular cells with an increase in lysosomes possibly associated with a degenerative process. Further studies are necessary to clarify the origin of these cells.Brazilian Society of Oral Medicine and Oral Pathology (SOBEP).Polti Lucas Fabian, Universidad de Buenos Aires (Uruguay). Facultad de Odontología.Sicco Estefanía, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.Silveira Felipe Martins, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.Schuch Lauren Frenzel, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.Pereira-Prado Vanesa, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.Bologna-Molina Ronell, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.Paparella María Luisa, Universidad de Buenos Aires (Uruguay). Facultad de Odontología.2025-09-17T17:22:19Z2025-09-17T17:22:19Z2025Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion9 h.application/pdfPolti, L, Sicco, E, Silveira, F [y otros autores]. "Granular cells in ghost cell odontogenic lesions: an unusual and unexpected finding". Journal of Oral Diagnosis. [en línea] 2025, 10:e354. 9 h.2525-5711https://hdl.handle.net/20.500.12008/5167610.5327/2525-5711.34reponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la Repúblicaen_USengJournal of Oral Diagnosis, 2025, 10:e354.Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC - By 4.0)oai:colibri.udelar.edu.uy:20.500.12008/516762026-04-14T10:37:15Z |
| spellingShingle | Granular cells in ghost cell odontogenic lesions: an unusual and unexpected finding Polti, Lucas Fabian Ghost cell Odontogenic lesions Calcifying odontogenic cyst Dentinogenic ghost cell tumor Granular cells Immunohistochemistry QUISTE ODONTOGÉNICO CALCIFICADO INMUNOHISTOQUÍMICA |
| status_str | publishedVersion |
| title | Granular cells in ghost cell odontogenic lesions: an unusual and unexpected finding |
| title_full | Granular cells in ghost cell odontogenic lesions: an unusual and unexpected finding |
| title_fullStr | Granular cells in ghost cell odontogenic lesions: an unusual and unexpected finding |
| title_full_unstemmed | Granular cells in ghost cell odontogenic lesions: an unusual and unexpected finding |
| title_short | Granular cells in ghost cell odontogenic lesions: an unusual and unexpected finding |
| title_sort | Granular cells in ghost cell odontogenic lesions: an unusual and unexpected finding |
| topic | Ghost cell Odontogenic lesions Calcifying odontogenic cyst Dentinogenic ghost cell tumor Granular cells Immunohistochemistry QUISTE ODONTOGÉNICO CALCIFICADO INMUNOHISTOQUÍMICA |
| url | https://hdl.handle.net/20.500.12008/51676 |