An isochore-like structure in the genome of the flatworm schistosoma mansoni
Eukaryotic genomes are compositionally heterogeneous, that is, composed by regions that differ in guanine–cytosine (GC) content (isochores). The most well documented case is that of vertebrates (mainly mammals) although it has been also noted among unicellular eukaryotes and invertebrates. In the hu...
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| Natura: | article |
| Lingua: | inglese |
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2016
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| Accesso online: | https://hdl.handle.net/20.500.12008/22057 |
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| _version_ | 1868890223609380864 |
|---|---|
| author | Lamolle, Guillermo |
| author2 | Protasio, Anna V. Iriarte, Andrés Jara Tellechea, Eugenio Salvador Simón, Diego Musto, Héctor |
| author2_role | author author author author author |
| author_browse | Iriarte, Andrés Jara Tellechea, Eugenio Salvador Lamolle, Guillermo Musto, Héctor Protasio, Anna V. Simón, Diego |
| author_facet | Lamolle, Guillermo Protasio, Anna V. Iriarte, Andrés Jara Tellechea, Eugenio Salvador Simón, Diego Musto, Héctor |
| author_role | author |
| collection | COLIBRI |
| dc.contributor.none.fl_str_mv | Lamolle, Guillermo. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología Protasio, A.V. Iriarte, Andrés. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología Jara Tellechea, Eugenio Salvador. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología Simón, Diego. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología Musto Mancebo, Héctor Mario. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología |
| dc.creator.none.fl_str_mv | Lamolle, Guillermo Protasio, Anna V. Iriarte, Andrés Jara Tellechea, Eugenio Salvador Simón, Diego Musto, Héctor |
| dc.date.none.fl_str_mv | 2016 2019-10-02T22:12:06Z 2019-10-02T22:12:06Z 20190930 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Lamolle, G., et al. An isochore-like structure in the genome of the flatworm schistosoma mansoni. Genome Biology and Evolution, 2016, 8 (8): 2312-2318. doi: 10.1093/gbe/evw170 1759-6653 https://hdl.handle.net/20.500.12008/22057 10.1093/gbe/evw170 |
| dc.language.none.fl_str_mv | en eng |
| dc.publisher.none.fl_str_mv | Oxford University Press |
| dc.relation.none.fl_str_mv | Genome Biology and Evolution, 2016, 8 (8): 2312-2318 |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess Licencia Creative Commons Atribución – No Comercial (CC-BY-NC- 4.0) |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.none.fl_str_mv | Compositional correlations Genome evolution Isochores Schistosoma mansoni |
| dc.title.none.fl_str_mv | An isochore-like structure in the genome of the flatworm schistosoma mansoni |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Eukaryotic genomes are compositionally heterogeneous, that is, composed by regions that differ in guanine–cytosine (GC) content (isochores). The most well documented case is that of vertebrates (mainly mammals) although it has been also noted among unicellular eukaryotes and invertebrates. In the human genome, regarded as a typical mammal, this heterogeneity is associated with several features. Specifically, genes located in GC-richest regions are the GC3-richest, display CpG islands and have shorter introns. Furthermore, these genes are more heavily expressed and tend to be located at the extremes of the chromosomes. Although the compositional heterogeneity seems to be widespread among eukaryotes, the associated properties noted in the human genome and other mammals have not been investigated in depth in other taxa. Here we provide evidence that the genome of the parasitic flatworm Schistosoma mansoni is compositionally heterogeneous and exhibits an isochore-like structure, displaying some features associated, until now, only with the human and other vertebrate genomes, with the exception of gene concentration. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_eae9a2e10953e9e4dffc3ef762f2aa0f |
| identifier_str_mv | Lamolle, G., et al. An isochore-like structure in the genome of the flatworm schistosoma mansoni. Genome Biology and Evolution, 2016, 8 (8): 2312-2318. doi: 10.1093/gbe/evw170 1759-6653 10.1093/gbe/evw170 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/22057 |
| publishDate | 2016 |
| publishDateSort | 2016 |
| publisher.none.fl_str_mv | Oxford University Press |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Licencia Creative Commons Atribución – No Comercial (CC-BY-NC- 4.0) |
| spelling | An isochore-like structure in the genome of the flatworm schistosoma mansoniLamolle, GuillermoProtasio, Anna V.Iriarte, AndrésJara Tellechea, Eugenio SalvadorSimón, DiegoMusto, HéctorCompositional correlationsGenome evolutionIsochoresSchistosoma mansoniEukaryotic genomes are compositionally heterogeneous, that is, composed by regions that differ in guanine–cytosine (GC) content (isochores). The most well documented case is that of vertebrates (mainly mammals) although it has been also noted among unicellular eukaryotes and invertebrates. In the human genome, regarded as a typical mammal, this heterogeneity is associated with several features. Specifically, genes located in GC-richest regions are the GC3-richest, display CpG islands and have shorter introns. Furthermore, these genes are more heavily expressed and tend to be located at the extremes of the chromosomes. Although the compositional heterogeneity seems to be widespread among eukaryotes, the associated properties noted in the human genome and other mammals have not been investigated in depth in other taxa. Here we provide evidence that the genome of the parasitic flatworm Schistosoma mansoni is compositionally heterogeneous and exhibits an isochore-like structure, displaying some features associated, until now, only with the human and other vertebrate genomes, with the exception of gene concentration.Oxford University PressLamolle, Guillermo. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de BiologíaProtasio, A.V.Iriarte, Andrés. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de BiologíaJara Tellechea, Eugenio Salvador. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de BiologíaSimón, Diego. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de BiologíaMusto Mancebo, Héctor Mario. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología2019-10-02T22:12:06Z2019-10-02T22:12:06Z201620190930Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfLamolle, G., et al. An isochore-like structure in the genome of the flatworm schistosoma mansoni. Genome Biology and Evolution, 2016, 8 (8): 2312-2318. doi: 10.1093/gbe/evw1701759-6653https://hdl.handle.net/20.500.12008/2205710.1093/gbe/evw170reponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaenengGenome Biology and Evolution, 2016, 8 (8): 2312-2318Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad De La República. (Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución – No Comercial (CC-BY-NC- 4.0)oai:colibri.udelar.edu.uy:20.500.12008/220572026-04-14T10:09:17Z |
| spellingShingle | An isochore-like structure in the genome of the flatworm schistosoma mansoni Lamolle, Guillermo Compositional correlations Genome evolution Isochores Schistosoma mansoni |
| status_str | publishedVersion |
| title | An isochore-like structure in the genome of the flatworm schistosoma mansoni |
| title_full | An isochore-like structure in the genome of the flatworm schistosoma mansoni |
| title_fullStr | An isochore-like structure in the genome of the flatworm schistosoma mansoni |
| title_full_unstemmed | An isochore-like structure in the genome of the flatworm schistosoma mansoni |
| title_short | An isochore-like structure in the genome of the flatworm schistosoma mansoni |
| title_sort | An isochore-like structure in the genome of the flatworm schistosoma mansoni |
| topic | Compositional correlations Genome evolution Isochores Schistosoma mansoni |
| url | https://hdl.handle.net/20.500.12008/22057 |