Omics data integration facilitates target selection for new antiparasitic drugs against TriTryp infections.
Introduction: Trypanosoma cruzi, Trypanosoma brucei, and Leishmania spp., commonly referred to as TriTryps, are a group of protozoan parasites that cause important human diseases affecting millions of people belonging to the most vulnerable populations worldwide. Current treatments have limited effi...
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| Other Authors: | , , , , , , |
| Format: | article |
| Language: | English |
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2023
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| Online Access: | https://hdl.handle.net/20.500.12008/43273 |
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| _version_ | 1868890217563291649 |
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| author | Rivara-Espasandín, Martín |
| author2 | Palumbo, Miranda Clara Sosa, Ezequiel J. Radío, Santiago Turjanski, Adrián G. Sotelo-Silveira, José Roberto Fernández Do Porto, Dario Smircich, Pablo |
| author2_role | author author author author author author author |
| author_browse | Fernández Do Porto, Dario Palumbo, Miranda Clara Radío, Santiago Rivara-Espasandín, Martín Smircich, Pablo Sosa, Ezequiel J. Sotelo-Silveira, José Roberto Turjanski, Adrián G. |
| author_facet | Rivara-Espasandín, Martín Palumbo, Miranda Clara Sosa, Ezequiel J. Radío, Santiago Turjanski, Adrián G. Sotelo-Silveira, José Roberto Fernández Do Porto, Dario Smircich, Pablo |
| author_role | author |
| collection | COLIBRI |
| dc.contributor.none.fl_str_mv | Rivara-Espasandín Martín, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. Palumbo Miranda Clara Sosa Ezequiel J. Radío Santiago, IIBCE Turjanski Adrián G. Sotelo-Silveira José Roberto, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. Fernández Do Porto Dario Smircich Pablo, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. |
| dc.creator.none.fl_str_mv | Rivara-Espasandín, Martín Palumbo, Miranda Clara Sosa, Ezequiel J. Radío, Santiago Turjanski, Adrián G. Sotelo-Silveira, José Roberto Fernández Do Porto, Dario Smircich, Pablo |
| dc.date.none.fl_str_mv | 2023 2024-04-01T13:38:12Z 2024-04-01T13:38:12Z |
| dc.format.none.fl_str_mv | 10 h. application/pdf |
| dc.identifier.none.fl_str_mv | Rivara-Espasandín, M, Palumbo, M, Sosa, E y otros. "Omics data integration facilitates target selection for new antiparasitic drugs against TriTryp infections". Frontiers in Pharmacology. [en línea] 2023, 14: 1136321. 10 h. DOI: 10.3389/fphar.2023.1136321. 1663-9812 https://hdl.handle.net/20.500.12008/43273 10.3389/fphar.2023.1136321 |
| dc.language.none.fl_str_mv | en eng |
| dc.publisher.none.fl_str_mv | Frontiers |
| dc.relation.none.fl_str_mv | Frontiers in Pharmacology, 2023, 14: 1136321. |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess Licencia Creative Commons Atribución (CC - By 4.0) |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.none.fl_str_mv | Trypanosomatids Drug discovery Genomics Neglected disease Target selection |
| dc.title.none.fl_str_mv | Omics data integration facilitates target selection for new antiparasitic drugs against TriTryp infections. |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Introduction: Trypanosoma cruzi, Trypanosoma brucei, and Leishmania spp., commonly referred to as TriTryps, are a group of protozoan parasites that cause important human diseases affecting millions of people belonging to the most vulnerable populations worldwide. Current treatments have limited efficiencies and can cause serious side effects, so there is an urgent need to develop new control strategies. Presently, the identification and prioritization of appropriate targets can be aided by integrative genomic and computational approaches. Methods: In this work, we conducted a genome-wide multidimensional data integration strategy to prioritize drug targets. We included genomic, transcriptomic, metabolic, and protein structural data sources, to delineate candidate proteins with relevant features for target selection in drug development. Results and Discussion: Our final ranked list includes proteins shared by TriTryps and covers a range of biological functions including essential proteins for parasite survival or growth, oxidative stress-related enzymes, virulence factors, and proteins that are exclusive to these parasites. Our strategy found previously described candidates, which validates our approach as well as new proteins that can be attractive targets to consider during the initial steps of drug discovery |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_e41f2f742e2a9969781931bedd41b8e9 |
| identifier_str_mv | Rivara-Espasandín, M, Palumbo, M, Sosa, E y otros. "Omics data integration facilitates target selection for new antiparasitic drugs against TriTryp infections". Frontiers in Pharmacology. [en línea] 2023, 14: 1136321. 10 h. DOI: 10.3389/fphar.2023.1136321. 1663-9812 10.3389/fphar.2023.1136321 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/43273 |
| publishDate | 2023 |
| publishDateSort | 2023 |
| publisher.none.fl_str_mv | Frontiers |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| spelling | Omics data integration facilitates target selection for new antiparasitic drugs against TriTryp infections.Rivara-Espasandín, MartínPalumbo, Miranda ClaraSosa, Ezequiel J.Radío, SantiagoTurjanski, Adrián G.Sotelo-Silveira, José RobertoFernández Do Porto, DarioSmircich, PabloTrypanosomatidsDrug discoveryGenomicsNeglected diseaseTarget selectionIntroduction: Trypanosoma cruzi, Trypanosoma brucei, and Leishmania spp., commonly referred to as TriTryps, are a group of protozoan parasites that cause important human diseases affecting millions of people belonging to the most vulnerable populations worldwide. Current treatments have limited efficiencies and can cause serious side effects, so there is an urgent need to develop new control strategies. Presently, the identification and prioritization of appropriate targets can be aided by integrative genomic and computational approaches. Methods: In this work, we conducted a genome-wide multidimensional data integration strategy to prioritize drug targets. We included genomic, transcriptomic, metabolic, and protein structural data sources, to delineate candidate proteins with relevant features for target selection in drug development. Results and Discussion: Our final ranked list includes proteins shared by TriTryps and covers a range of biological functions including essential proteins for parasite survival or growth, oxidative stress-related enzymes, virulence factors, and proteins that are exclusive to these parasites. Our strategy found previously described candidates, which validates our approach as well as new proteins that can be attractive targets to consider during the initial steps of drug discoveryFrontiersRivara-Espasandín Martín, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología.Palumbo Miranda ClaraSosa Ezequiel J.Radío Santiago, IIBCETurjanski Adrián G.Sotelo-Silveira José Roberto, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología.Fernández Do Porto DarioSmircich Pablo, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología.2024-04-01T13:38:12Z2024-04-01T13:38:12Z2023Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion10 h.application/pdfRivara-Espasandín, M, Palumbo, M, Sosa, E y otros. "Omics data integration facilitates target selection for new antiparasitic drugs against TriTryp infections". Frontiers in Pharmacology. [en línea] 2023, 14: 1136321. 10 h. DOI: 10.3389/fphar.2023.1136321.1663-9812https://hdl.handle.net/20.500.12008/4327310.3389/fphar.2023.1136321reponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaenengFrontiers in Pharmacology, 2023, 14: 1136321.Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC - By 4.0)oai:colibri.udelar.edu.uy:20.500.12008/432732026-04-14T10:10:35Z |
| spellingShingle | Omics data integration facilitates target selection for new antiparasitic drugs against TriTryp infections. Rivara-Espasandín, Martín Trypanosomatids Drug discovery Genomics Neglected disease Target selection |
| status_str | publishedVersion |
| title | Omics data integration facilitates target selection for new antiparasitic drugs against TriTryp infections. |
| title_full | Omics data integration facilitates target selection for new antiparasitic drugs against TriTryp infections. |
| title_fullStr | Omics data integration facilitates target selection for new antiparasitic drugs against TriTryp infections. |
| title_full_unstemmed | Omics data integration facilitates target selection for new antiparasitic drugs against TriTryp infections. |
| title_short | Omics data integration facilitates target selection for new antiparasitic drugs against TriTryp infections. |
| title_sort | Omics data integration facilitates target selection for new antiparasitic drugs against TriTryp infections. |
| topic | Trypanosomatids Drug discovery Genomics Neglected disease Target selection |
| url | https://hdl.handle.net/20.500.12008/43273 |