Re-appraising the evidence for the source, regulation and function of p53-family isoforms
The p53 family of proteins evolved from a common ancestor into three separate genes encoding proteins that act as transcription factors with distinct cellular roles. Isoforms of each member that lack specific regions or domains are suggested to result from alternative transcription start sites, alte...
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| Other Authors: | , , , |
| Format: | article |
| Language: | English |
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2024
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| Online Access: | https://hdl.handle.net/20.500.12008/46610 |
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| _version_ | 1868890216535687168 |
|---|---|
| author | López Ferreira, Luis Ignacio |
| author2 | Larghero Valdivia, Irene Vojtesek, Borivoj Fahraeus, Robin Coates, Philip J. |
| author2_role | author author author author |
| author_browse | Coates, Philip J. Fahraeus, Robin Larghero Valdivia, Irene López Ferreira, Luis Ignacio Vojtesek, Borivoj |
| author_facet | López Ferreira, Luis Ignacio Larghero Valdivia, Irene Vojtesek, Borivoj Fahraeus, Robin Coates, Philip J. |
| author_role | author |
| collection | COLIBRI |
| dc.contributor.none.fl_str_mv | López Ferreira Luis Ignacio, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica. Larghero Valdivia Irene, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica. Vojtesek Borivoj Fahraeus Robin Coates Philip J. |
| dc.creator.none.fl_str_mv | López Ferreira, Luis Ignacio Larghero Valdivia, Irene Vojtesek, Borivoj Fahraeus, Robin Coates, Philip J. |
| dc.date.none.fl_str_mv | 2024-10-25T17:24:46Z 2024-10-25T17:24:46Z 2024 |
| dc.format.none.fl_str_mv | 18 h. application/pdf |
| dc.identifier.none.fl_str_mv | López Ferreira, L, Larghero Valdivia, I, Vojtesek, B, [y otros]. "Re-appraising the evidence for the source, regulation and function of p53-family isoforms". Nucleic Acids Research. [en línea] 2024: 1-18. DOI: 10.1093/nar/gkae855 1362-4962 https://hdl.handle.net/20.500.12008/46610 10.1093/nar/gkae855 |
| dc.language.none.fl_str_mv | en eng |
| dc.publisher.none.fl_str_mv | Oxford University Press |
| dc.relation.none.fl_str_mv | Nucleic Acids Research, 2024: 1-18 |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess Licencia Creative Commons Atribución (CC - By 4.0) |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.none.fl_str_mv | Proteins p53-family isoforms |
| dc.title.none.fl_str_mv | Re-appraising the evidence for the source, regulation and function of p53-family isoforms |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | The p53 family of proteins evolved from a common ancestor into three separate genes encoding proteins that act as transcription factors with distinct cellular roles. Isoforms of each member that lack specific regions or domains are suggested to result from alternative transcription start sites, alternative splicing or alternative translation initiation, and have the potential to exponentially increase the functional repertoire of each gene. However, evidence supporting the presence of individual protein variants at functional levels is often limited and is inferred by mRNA detection using highly sensitive amplification techniques. We provide a critical appraisal of the current evidence for the origins, expression, functions and regulation of p53-family isoforms. We conclude that despite the wealth of publications, several putative isoforms remain poorly established. Future research with improved technical approaches and the generation of isoform-specific protein detection reagents is required to establish the physiological relevance of p53-family isoforms in health and disease. In addition, our analyses suggest that p53-family variants evolved partly through convergent rather than divergent evolution from the ancestral gene. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_e2b2c9fb5cfa59d1d2d2c924857e9bce |
| identifier_str_mv | López Ferreira, L, Larghero Valdivia, I, Vojtesek, B, [y otros]. "Re-appraising the evidence for the source, regulation and function of p53-family isoforms". Nucleic Acids Research. [en línea] 2024: 1-18. DOI: 10.1093/nar/gkae855 1362-4962 10.1093/nar/gkae855 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/46610 |
| publishDate | 2024 |
| publishDateSort | 2024 |
| publisher.none.fl_str_mv | Oxford University Press |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| spelling | Re-appraising the evidence for the source, regulation and function of p53-family isoformsLópez Ferreira, Luis IgnacioLarghero Valdivia, IreneVojtesek, BorivojFahraeus, RobinCoates, Philip J.Proteinsp53-familyisoformsThe p53 family of proteins evolved from a common ancestor into three separate genes encoding proteins that act as transcription factors with distinct cellular roles. Isoforms of each member that lack specific regions or domains are suggested to result from alternative transcription start sites, alternative splicing or alternative translation initiation, and have the potential to exponentially increase the functional repertoire of each gene. However, evidence supporting the presence of individual protein variants at functional levels is often limited and is inferred by mRNA detection using highly sensitive amplification techniques. We provide a critical appraisal of the current evidence for the origins, expression, functions and regulation of p53-family isoforms. We conclude that despite the wealth of publications, several putative isoforms remain poorly established. Future research with improved technical approaches and the generation of isoform-specific protein detection reagents is required to establish the physiological relevance of p53-family isoforms in health and disease. In addition, our analyses suggest that p53-family variants evolved partly through convergent rather than divergent evolution from the ancestral gene.ANII: FCE_3_2020_1_161877ANII: FCE_1_2023_1_175762ANII: MOV_CA_2023_1_176782Oxford University PressLópez Ferreira Luis Ignacio, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica.Larghero Valdivia Irene, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica.Vojtesek BorivojFahraeus RobinCoates Philip J.2024-10-25T17:24:46Z2024-10-25T17:24:46Z2024Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion18 h.application/pdfLópez Ferreira, L, Larghero Valdivia, I, Vojtesek, B, [y otros]. "Re-appraising the evidence for the source, regulation and function of p53-family isoforms". Nucleic Acids Research. [en línea] 2024: 1-18. DOI: 10.1093/nar/gkae8551362-4962https://hdl.handle.net/20.500.12008/4661010.1093/nar/gkae855reponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaenengNucleic Acids Research, 2024: 1-18Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC - By 4.0)oai:colibri.udelar.edu.uy:20.500.12008/466102026-04-14T10:10:42Z |
| spellingShingle | Re-appraising the evidence for the source, regulation and function of p53-family isoforms López Ferreira, Luis Ignacio Proteins p53-family isoforms |
| status_str | publishedVersion |
| title | Re-appraising the evidence for the source, regulation and function of p53-family isoforms |
| title_full | Re-appraising the evidence for the source, regulation and function of p53-family isoforms |
| title_fullStr | Re-appraising the evidence for the source, regulation and function of p53-family isoforms |
| title_full_unstemmed | Re-appraising the evidence for the source, regulation and function of p53-family isoforms |
| title_short | Re-appraising the evidence for the source, regulation and function of p53-family isoforms |
| title_sort | Re-appraising the evidence for the source, regulation and function of p53-family isoforms |
| topic | Proteins p53-family isoforms |
| url | https://hdl.handle.net/20.500.12008/46610 |