Central nervous system lesions caused by canine distemper virus in 4 vaccinated dogs
We examined the cerebellum and cerebrum of 4 vaccinated dogs, 3–60-mo-old, that displayed clinical signs of canine distemper virus (CDV) infection, and died 7–40 d after developing neurologic signs. The main histologic lesions were demyelination, gliosis, meningitis, perivascular lymphocytic cuffing...
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| Médium: | article |
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2021
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| On-line přístup: | https://hdl.handle.net/20.500.12008/48318 https://doi-org.proxy.timbo.org.uy/10.1177/10406387211009210 |
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| _version_ | 1868890215535345664 |
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| author | Feijóo, Gimena |
| author2 | Yamasaki, Kanji Delucchi, Luis Verdes García, José Manuel |
| author2_role | author author author |
| author_browse | Delucchi, Luis Feijóo, Gimena Verdes García, José Manuel Yamasaki, Kanji |
| author_facet | Feijóo, Gimena Yamasaki, Kanji Delucchi, Luis Verdes García, José Manuel |
| author_role | author |
| collection | COLIBRI |
| dc.contributor.none.fl_str_mv | Feijóo Gimena, Universidad de la República (Uruguay). Veterinary Faculty. Department of Pathobiology Yamasaki Kanji, Universidad de la República (Uruguay). Veterinary Faculty. Department of Pathobiology Delucchi Luis, Universidad de la República (Uruguay). Veterinary Faculty. Department of Pathobiology Verdes García José Manuel, Universidad de la República (Uruguay). Veterinary Faculty. Department of Pathobiology |
| dc.creator.none.fl_str_mv | Feijóo, Gimena Yamasaki, Kanji Delucchi, Luis Verdes García, José Manuel |
| dc.date.none.fl_str_mv | 2021 2025-02-10T15:34:21Z 2025-02-10T15:34:21Z |
| dc.format.none.fl_str_mv | 8 p application/pdf |
| dc.identifier.none.fl_str_mv | Feijóo, G, Yamasaki, K, Delucchi, L y Verdes García, J. Central nervous system lesions caused by canine distemper virus in 4 vaccinated dogs. Journal of Veterinary Diagnostic Investigation. [en línea] 2021, 33(4), 640-647 https://hdl.handle.net/20.500.12008/48318 https://doi-org.proxy.timbo.org.uy/10.1177/10406387211009210 |
| dc.language.none.fl_str_mv | en eng |
| dc.relation.none.fl_str_mv | Journal of Veterinary Diagnostic Investigation, 2021, 33(4), 640-647 |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.none.fl_str_mv | PERROS PEQUEÑOS ANIMALES VIROSIS VACUNACION NEUROPATIAS |
| dc.title.none.fl_str_mv | Central nervous system lesions caused by canine distemper virus in 4 vaccinated dogs |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | We examined the cerebellum and cerebrum of 4 vaccinated dogs, 3–60-mo-old, that displayed clinical signs of canine distemper virus (CDV) infection, and died 7–40 d after developing neurologic signs. The main histologic lesions were demyelination, gliosis, meningitis, perivascular lymphocytic cuffing, and inclusion bodies. These lesions were similar in all 4 cases regardless of the time since vaccination, except that meningoencephalitis and gliosis were subacute in 3 dogs and chronic in 1 dog. However, these differences did not appear to be related to their vaccination status. Immunohistologically, a CDVpositive immunoreaction was seen mainly in astrocytes, neurons and their axons, lymphocytes around and in the blood vessels of the pia mater and choroid plexus, ependymal cells of each ventricle, and the cells of the choroid plexus. The histologic and immunohistologic changes were similar in the cerebellum and cerebrum. The genetic characterization of the virus strains in 2 of these naturally occurring canine distemper cases confirmed that they were South American wild-type strains (Kiki and Uy251) belonging to the EU1/SA1 lineage. These strains are not included in the commercial CDV vaccines available in Uruguay. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_e1bacfaf64fd78ec3da4bbfc136c5426 |
| identifier_str_mv | Feijóo, G, Yamasaki, K, Delucchi, L y Verdes García, J. Central nervous system lesions caused by canine distemper virus in 4 vaccinated dogs. Journal of Veterinary Diagnostic Investigation. [en línea] 2021, 33(4), 640-647 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/48318 |
| publishDate | 2021 |
| publishDateSort | 2021 |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
| spelling | Central nervous system lesions caused by canine distemper virus in 4 vaccinated dogsFeijóo, GimenaYamasaki, KanjiDelucchi, LuisVerdes García, José ManuelPERROSPEQUEÑOS ANIMALESVIROSISVACUNACIONNEUROPATIASWe examined the cerebellum and cerebrum of 4 vaccinated dogs, 3–60-mo-old, that displayed clinical signs of canine distemper virus (CDV) infection, and died 7–40 d after developing neurologic signs. The main histologic lesions were demyelination, gliosis, meningitis, perivascular lymphocytic cuffing, and inclusion bodies. These lesions were similar in all 4 cases regardless of the time since vaccination, except that meningoencephalitis and gliosis were subacute in 3 dogs and chronic in 1 dog. However, these differences did not appear to be related to their vaccination status. Immunohistologically, a CDVpositive immunoreaction was seen mainly in astrocytes, neurons and their axons, lymphocytes around and in the blood vessels of the pia mater and choroid plexus, ependymal cells of each ventricle, and the cells of the choroid plexus. The histologic and immunohistologic changes were similar in the cerebellum and cerebrum. The genetic characterization of the virus strains in 2 of these naturally occurring canine distemper cases confirmed that they were South American wild-type strains (Kiki and Uy251) belonging to the EU1/SA1 lineage. These strains are not included in the commercial CDV vaccines available in Uruguay.Feijóo Gimena, Universidad de la República (Uruguay). Veterinary Faculty. Department of PathobiologyYamasaki Kanji, Universidad de la República (Uruguay). Veterinary Faculty. Department of PathobiologyDelucchi Luis, Universidad de la República (Uruguay). Veterinary Faculty. Department of PathobiologyVerdes García José Manuel, Universidad de la República (Uruguay). Veterinary Faculty. Department of Pathobiology2025-02-10T15:34:21Z2025-02-10T15:34:21Z2021Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion8 papplication/pdfFeijóo, G, Yamasaki, K, Delucchi, L y Verdes García, J. Central nervous system lesions caused by canine distemper virus in 4 vaccinated dogs. Journal of Veterinary Diagnostic Investigation. [en línea] 2021, 33(4), 640-647https://hdl.handle.net/20.500.12008/48318https://doi-org.proxy.timbo.org.uy/10.1177/10406387211009210reponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaenengJournal of Veterinary Diagnostic Investigation, 2021, 33(4), 640-647Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0)oai:colibri.udelar.edu.uy:20.500.12008/483182026-04-14T10:35:05Z |
| spellingShingle | Central nervous system lesions caused by canine distemper virus in 4 vaccinated dogs Feijóo, Gimena PERROS PEQUEÑOS ANIMALES VIROSIS VACUNACION NEUROPATIAS |
| status_str | publishedVersion |
| title | Central nervous system lesions caused by canine distemper virus in 4 vaccinated dogs |
| title_full | Central nervous system lesions caused by canine distemper virus in 4 vaccinated dogs |
| title_fullStr | Central nervous system lesions caused by canine distemper virus in 4 vaccinated dogs |
| title_full_unstemmed | Central nervous system lesions caused by canine distemper virus in 4 vaccinated dogs |
| title_short | Central nervous system lesions caused by canine distemper virus in 4 vaccinated dogs |
| title_sort | Central nervous system lesions caused by canine distemper virus in 4 vaccinated dogs |
| topic | PERROS PEQUEÑOS ANIMALES VIROSIS VACUNACION NEUROPATIAS |
| url | https://hdl.handle.net/20.500.12008/48318 https://doi-org.proxy.timbo.org.uy/10.1177/10406387211009210 |