On the track of the missing tRNA genes: a source of non-canonical functions?
Cellular tRNAs appear today as a diverse population of informative macromolecules with conserved general elements ensuring essential common functions and different and distinctive features securing specific interactions and activities. Their differential expression and the variety of post-transcript...
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| Beste egile batzuk: | , , , |
| Formatua: | article |
| Hizkuntza: | ingelesa |
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2021
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| Sarrera elektronikoa: | https://hdl.handle.net/20.500.12008/40943 |
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Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!
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| _version_ | 1868890214584287232 |
|---|---|
| author | Ehrlich, Ricardo |
| author2 | Davyt Borthagaray, Marcos López, Ignacio Chalar, Cora Marín Gutiérrez, Mónica |
| author2_role | author author author author |
| author_browse | Chalar, Cora Davyt Borthagaray, Marcos Ehrlich, Ricardo López, Ignacio Marín Gutiérrez, Mónica |
| author_facet | Ehrlich, Ricardo Davyt Borthagaray, Marcos López, Ignacio Chalar, Cora Marín Gutiérrez, Mónica |
| author_role | author |
| collection | COLIBRI |
| dc.contributor.none.fl_str_mv | Ehrlich Ricardo, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. Davyt Borthagaray Marcos, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. López Ignacio, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. Chalar Cora, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. Marín Gutiérrez Mónica, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. |
| dc.creator.none.fl_str_mv | Ehrlich, Ricardo Davyt Borthagaray, Marcos López, Ignacio Chalar, Cora Marín Gutiérrez, Mónica |
| dc.date.none.fl_str_mv | 2021 2023-11-06T15:39:09Z 2023-11-06T15:39:09Z |
| dc.format.none.fl_str_mv | 15 h. application/pdf |
| dc.identifier.none.fl_str_mv | Ehrlich, R, Davyt Borthagaray, M, López, I, [y otros autores] "On the track of the missing tRNA genes: a source of non-canonical functions?". Frontiers in Molecular Biosciences. [en línea] 2021, 8: 643701. 15 h. DOI: 10.3389/fmolb.2021.643701. 2296-889X https://hdl.handle.net/20.500.12008/40943 10.3389/fmolb.2021.643701 |
| dc.language.none.fl_str_mv | en eng |
| dc.publisher.none.fl_str_mv | Frontiers |
| dc.relation.none.fl_str_mv | Frontiers in Molecular Biosciences, 2021, 8: 643701. |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess Licencia Creative Commons Atribución (CC - By 4.0) |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.none.fl_str_mv | Missing tRNAs tRNA functions tRNA modifications tRNA interactions Non-canonical tRNA functions tRNA structure |
| dc.title.none.fl_str_mv | On the track of the missing tRNA genes: a source of non-canonical functions? |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Cellular tRNAs appear today as a diverse population of informative macromolecules with conserved general elements ensuring essential common functions and different and distinctive features securing specific interactions and activities. Their differential expression and the variety of post-transcriptional modifications they are subject to, lead to the existence of complex repertoires of tRNA populations adjusted to defined cellular states. Despite the tRNA-coding genes redundancy in prokaryote and eukaryote genomes, it is surprising to note the absence of genes coding specific translational-active isoacceptors throughout the phylogeny. Through the analysis of different releases of tRNA databases, this review aims to provide a general summary about those “missing tRNA genes.” This absence refers to both tRNAs that are not encoded in the genome, as well as others that show critical sequence variations that would prevent their activity as canonical translation adaptor molecules. Notably, while a group of genes are universally missing, others are absent in particular kingdoms. Functional information available allows to hypothesize that the exclusion of isodecoding molecules would be linked to: 1) reduce ambiguities of signals that define the specificity of the interactions in which the tRNAs are involved; 2) ensure the adaptation of the translational apparatus to the cellular state; 3) divert particular tRNA variants from ribosomal protein synthesis to other cellular functions. This leads to consider the “missing tRNA genes” as a source of putative non-canonical tRNA functions and to broaden the concept of adapter molecules in ribosomal-dependent protein synthesis. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_e156100ca43035be9d8ea71a15fb4cfa |
| identifier_str_mv | Ehrlich, R, Davyt Borthagaray, M, López, I, [y otros autores] "On the track of the missing tRNA genes: a source of non-canonical functions?". Frontiers in Molecular Biosciences. [en línea] 2021, 8: 643701. 15 h. DOI: 10.3389/fmolb.2021.643701. 2296-889X 10.3389/fmolb.2021.643701 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/40942 |
| publishDate | 2021 |
| publishDateSort | 2021 |
| publisher.none.fl_str_mv | Frontiers |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| spelling | On the track of the missing tRNA genes: a source of non-canonical functions?Ehrlich, RicardoDavyt Borthagaray, MarcosLópez, IgnacioChalar, CoraMarín Gutiérrez, MónicaMissing tRNAstRNA functionstRNA modificationstRNA interactionsNon-canonical tRNA functionstRNA structureCellular tRNAs appear today as a diverse population of informative macromolecules with conserved general elements ensuring essential common functions and different and distinctive features securing specific interactions and activities. Their differential expression and the variety of post-transcriptional modifications they are subject to, lead to the existence of complex repertoires of tRNA populations adjusted to defined cellular states. Despite the tRNA-coding genes redundancy in prokaryote and eukaryote genomes, it is surprising to note the absence of genes coding specific translational-active isoacceptors throughout the phylogeny. Through the analysis of different releases of tRNA databases, this review aims to provide a general summary about those “missing tRNA genes.” This absence refers to both tRNAs that are not encoded in the genome, as well as others that show critical sequence variations that would prevent their activity as canonical translation adaptor molecules. Notably, while a group of genes are universally missing, others are absent in particular kingdoms. Functional information available allows to hypothesize that the exclusion of isodecoding molecules would be linked to: 1) reduce ambiguities of signals that define the specificity of the interactions in which the tRNAs are involved; 2) ensure the adaptation of the translational apparatus to the cellular state; 3) divert particular tRNA variants from ribosomal protein synthesis to other cellular functions. This leads to consider the “missing tRNA genes” as a source of putative non-canonical tRNA functions and to broaden the concept of adapter molecules in ribosomal-dependent protein synthesis.FrontiersEhrlich Ricardo, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología.Davyt Borthagaray Marcos, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología.López Ignacio, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología.Chalar Cora, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología.Marín Gutiérrez Mónica, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología.2023-11-06T15:39:09Z2023-11-06T15:39:09Z2021Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion15 h.application/pdfEhrlich, R, Davyt Borthagaray, M, López, I, [y otros autores] "On the track of the missing tRNA genes: a source of non-canonical functions?". Frontiers in Molecular Biosciences. [en línea] 2021, 8: 643701. 15 h. DOI: 10.3389/fmolb.2021.643701.2296-889Xhttps://hdl.handle.net/20.500.12008/4094310.3389/fmolb.2021.643701reponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaenengFrontiers in Molecular Biosciences, 2021, 8: 643701.Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC - By 4.0)oai:colibri.udelar.edu.uy:20.500.12008/409422026-04-14T10:10:17Z |
| spellingShingle | On the track of the missing tRNA genes: a source of non-canonical functions? Ehrlich, Ricardo Missing tRNAs tRNA functions tRNA modifications tRNA interactions Non-canonical tRNA functions tRNA structure |
| status_str | publishedVersion |
| title | On the track of the missing tRNA genes: a source of non-canonical functions? |
| title_full | On the track of the missing tRNA genes: a source of non-canonical functions? |
| title_fullStr | On the track of the missing tRNA genes: a source of non-canonical functions? |
| title_full_unstemmed | On the track of the missing tRNA genes: a source of non-canonical functions? |
| title_short | On the track of the missing tRNA genes: a source of non-canonical functions? |
| title_sort | On the track of the missing tRNA genes: a source of non-canonical functions? |
| topic | Missing tRNAs tRNA functions tRNA modifications tRNA interactions Non-canonical tRNA functions tRNA structure |
| url | https://hdl.handle.net/20.500.12008/40943 |