Structural and Functional Insights into the Microtubule Organizing Centers of Toxoplasma gondii and Plasmodium spp.
Microtubule organizing centers (MTOCs) perform critical cellular tasks by nucleating, stabilizing, and anchoring microtubule’s minus ends. These capacities impact tremendously a wide array of cellular functions ranging from ascribing cell shape to orchestrating cell division and generating motile st...
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| Other Authors: | , |
| Format: | article |
| Language: | English |
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2021
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| Online Access: | https://hdl.handle.net/20.500.12008/50985 |
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| _version_ | 1868890205452238848 |
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| author | Tomasina, Ramiro |
| author2 | González, Fabiana C. Francia, Maria E. |
| author2_role | author author |
| author_browse | Francia, Maria E. González, Fabiana C. Tomasina, Ramiro |
| author_facet | Tomasina, Ramiro González, Fabiana C. Francia, Maria E. |
| author_role | author |
| collection | COLIBRI |
| dc.contributor.none.fl_str_mv | Tomasina Ramiro, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Parasitología y Micología González Fabiana C., Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Parasitología y Micología Francia Maria E., Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Parasitología y Micología |
| dc.creator.none.fl_str_mv | Tomasina, Ramiro González, Fabiana C. Francia, Maria E. |
| dc.date.none.fl_str_mv | 2021 2025-08-11T15:13:50Z 2025-08-11T15:13:50Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | TOMASINA, R., GONZÁLEZ, FC., y FRANCIA, ME. Structural and Functional Insights into the Microtubule Organizing Centers of Toxoplasma gondii and Plasmodium spp. Microorganisms [en línea] 2021, 9(12) 2503. DOI: 10.3390/microorganisms9122503 https://hdl.handle.net/20.500.12008/50985 10.3390/microorganisms9122503 |
| dc.language.none.fl_str_mv | en eng |
| dc.relation.none.fl_str_mv | Microorganisms. 9(12) 2503, 2021 |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess An error occurred getting the license - uri. Licencia Creative Commons Atribución (CC - By 4.0) |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.none.fl_str_mv | Microtubule organizing center Centrosome Centriolar plaque Plasmodium Toxoplasma gondii Ultrastructure expansion microscopy |
| dc.title.none.fl_str_mv | Structural and Functional Insights into the Microtubule Organizing Centers of Toxoplasma gondii and Plasmodium spp. |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Microtubule organizing centers (MTOCs) perform critical cellular tasks by nucleating, stabilizing, and anchoring microtubule’s minus ends. These capacities impact tremendously a wide array of cellular functions ranging from ascribing cell shape to orchestrating cell division and generating motile structures, among others. The phylum Apicomplexa comprises over 6000 single-celled obligate intracellular parasitic species. Many of the apicomplexan are well known pathogens such as Toxoplasma gondii and the Plasmodium species, causative agents of toxoplasmosis and malaria, respectively. Microtubule organization in these parasites is critical for organizing the cortical cytoskeleton, enabling host cell penetration and the positioning of large organelles, driving cell division and directing the formation of flagella in sexual life stages. Apicomplexans are a prime example of MTOC diversity displaying multiple functional and structural MTOCs combinations within a single species. This diversity can only be fully understood in light of each organism’s specific MT nucleation requirements and their evolutionary history. Insight into apicomplexan MTOCs had traditionally been limited to classical ultrastructural work by transmission electron microscopy. However, in the past few years, a large body of molecular insight has emerged. In this work we describe the latest insights into nuclear MTOC biology in two major human and animal disease causing Apicomplexans: Toxoplasma gondii and Plasmodium spp. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_d821246f61691bf24e2f1ff5a2a8ecbc |
| identifier_str_mv | TOMASINA, R., GONZÁLEZ, FC., y FRANCIA, ME. Structural and Functional Insights into the Microtubule Organizing Centers of Toxoplasma gondii and Plasmodium spp. Microorganisms [en línea] 2021, 9(12) 2503. DOI: 10.3390/microorganisms9122503 10.3390/microorganisms9122503 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/50985 |
| publishDate | 2021 |
| publishDateSort | 2021 |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | An error occurred getting the license - uri. Licencia Creative Commons Atribución (CC - By 4.0) |
| spelling | Structural and Functional Insights into the Microtubule Organizing Centers of Toxoplasma gondii and Plasmodium spp.Tomasina, RamiroGonzález, Fabiana C.Francia, Maria E.Microtubule organizing centerCentrosomeCentriolar plaquePlasmodiumToxoplasma gondiiUltrastructure expansion microscopyMicrotubule organizing centers (MTOCs) perform critical cellular tasks by nucleating, stabilizing, and anchoring microtubule’s minus ends. These capacities impact tremendously a wide array of cellular functions ranging from ascribing cell shape to orchestrating cell division and generating motile structures, among others. The phylum Apicomplexa comprises over 6000 single-celled obligate intracellular parasitic species. Many of the apicomplexan are well known pathogens such as Toxoplasma gondii and the Plasmodium species, causative agents of toxoplasmosis and malaria, respectively. Microtubule organization in these parasites is critical for organizing the cortical cytoskeleton, enabling host cell penetration and the positioning of large organelles, driving cell division and directing the formation of flagella in sexual life stages. Apicomplexans are a prime example of MTOC diversity displaying multiple functional and structural MTOCs combinations within a single species. This diversity can only be fully understood in light of each organism’s specific MT nucleation requirements and their evolutionary history. Insight into apicomplexan MTOCs had traditionally been limited to classical ultrastructural work by transmission electron microscopy. However, in the past few years, a large body of molecular insight has emerged. In this work we describe the latest insights into nuclear MTOC biology in two major human and animal disease causing Apicomplexans: Toxoplasma gondii and Plasmodium spp.Comisión Sectorial de Investigación Científica (CSIC)Banco de Seguros del Estado (BSE)Tomasina Ramiro, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Parasitología y MicologíaGonzález Fabiana C., Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Parasitología y MicologíaFrancia Maria E., Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Parasitología y Micología2025-08-11T15:13:50Z2025-08-11T15:13:50Z2021Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfTOMASINA, R., GONZÁLEZ, FC., y FRANCIA, ME. Structural and Functional Insights into the Microtubule Organizing Centers of Toxoplasma gondii and Plasmodium spp. Microorganisms [en línea] 2021, 9(12) 2503. DOI: 10.3390/microorganisms9122503https://hdl.handle.net/20.500.12008/5098510.3390/microorganisms9122503reponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaenengMicroorganisms. 9(12) 2503, 2021Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessAn error occurred getting the license - uri.Licencia Creative Commons Atribución (CC - By 4.0)oai:colibri.udelar.edu.uy:20.500.12008/509852026-04-14T10:37:04Z |
| spellingShingle | Structural and Functional Insights into the Microtubule Organizing Centers of Toxoplasma gondii and Plasmodium spp. Tomasina, Ramiro Microtubule organizing center Centrosome Centriolar plaque Plasmodium Toxoplasma gondii Ultrastructure expansion microscopy |
| status_str | publishedVersion |
| title | Structural and Functional Insights into the Microtubule Organizing Centers of Toxoplasma gondii and Plasmodium spp. |
| title_full | Structural and Functional Insights into the Microtubule Organizing Centers of Toxoplasma gondii and Plasmodium spp. |
| title_fullStr | Structural and Functional Insights into the Microtubule Organizing Centers of Toxoplasma gondii and Plasmodium spp. |
| title_full_unstemmed | Structural and Functional Insights into the Microtubule Organizing Centers of Toxoplasma gondii and Plasmodium spp. |
| title_short | Structural and Functional Insights into the Microtubule Organizing Centers of Toxoplasma gondii and Plasmodium spp. |
| title_sort | Structural and Functional Insights into the Microtubule Organizing Centers of Toxoplasma gondii and Plasmodium spp. |
| topic | Microtubule organizing center Centrosome Centriolar plaque Plasmodium Toxoplasma gondii Ultrastructure expansion microscopy |
| url | https://hdl.handle.net/20.500.12008/50985 |