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Characteristics of Community-Associated Methicillin-Resistant Staphylococcus aureus (CA-MRSA) Strains Isolated from Skin and Soft-Tissue Infections in Uruguay

We analyzed 90 nonduplicates community-associated methicillin-resistant S. aureus (CA-MRSA) strains isolated from skin and soft-tissue infections. All strains were mecA positive. Twenty-four of the 90 strains showed inducible macrolide-lincosamide streptogramin B resistance. All strains produced α-t...

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Hovedforfatter: Pardo, Lorena (author)
Andre forfattere: Machado, Virginia (author), Mollerach, Marta (author), Mota, María Inés (author), Tuchscherr, Lorena P. N. (author), Gadea, Pilar (author), Gardella, Noella (author), Sordelli, Daniel O. (author), Vola, Magdalena (author), Schelotto, Felipe (author), Varela, Gustavo (author)
Format: article
Sprog:engelsk
Udgivet: 2009
Fag:
METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS
SOFT TISSUE INFECTIONS
SKIN
Online adgang:https://hdl.handle.net/20.500.12008/52629
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Summary:We analyzed 90 nonduplicates community-associated methicillin-resistant S. aureus (CA-MRSA) strains isolated from skin and soft-tissue infections. All strains were mecA positive. Twenty-four of the 90 strains showed inducible macrolide-lincosamide streptogramin B resistance. All strains produced α-toxin; 96% and 100% of them displayed positive results for lukS-F and cna genes, respectively. Eigthy-five strains expressed capsular polysaccharide serotype 8. Six different pulsotypes were discriminated by pulsed-field gel electrophoresis (PFGE) and three predominant groups of CA-MRSA strains (1, 2, and 4) were identified, in agreement with phenotypic and genotypic characteristics. Strains of group 1 (pulsotype A, CP8+, and Panton-Valentine leukocidin (PVL)+) were the most frequently recovered and exhibited a PFGE band pattern identical to other CA-MRSA strains previously isolated in Uruguay and Brazil. Three years after the first local CA-MRSA report, these strains are still producing skin and soft tissue infections demonstrating the stability over time of this community-associated emerging pathogen.

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