Non-coding RNA fragments account for themajority of annotated piRNAs expressed in somaticnon-gonadal tissues
PIWI-interacting RNAs (piRNAs) are regarded as the guardians of the genome because theytackle genome stability-threatening transposable elements in the germline. Recently, piRNAswere also reported in other types of cells, including mouse brain, malignant and non-malignant somatic tissues, and human...
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| Médium: | article |
| Jazyk: | angličtina |
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2018
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| On-line přístup: | https://hdl.handle.net/20.500.12008/22005 |
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| _version_ | 1868890202327482368 |
|---|---|
| author | Tosar Rovira, Juan Pablo |
| author2 | Rovira, Carlos Cayota, Alfonso |
| author2_role | author author |
| author_browse | Cayota, Alfonso Rovira, Carlos Tosar Rovira, Juan Pablo |
| author_facet | Tosar Rovira, Juan Pablo Rovira, Carlos Cayota, Alfonso |
| author_role | author |
| collection | COLIBRI |
| dc.contributor.none.fl_str_mv | Tosar, Juan Pablo. Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares Cayota, Alfonso. Instituto Pasteur (Montevideo). |
| dc.creator.none.fl_str_mv | Tosar Rovira, Juan Pablo Rovira, Carlos Cayota, Alfonso |
| dc.date.none.fl_str_mv | 2018 2019-10-02T22:08:23Z 2019-10-02T22:08:23Z 20190930 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Tosar, J.P., Rovira, C.,Cayota, A. Non-coding RNA fragments account for the majority of annotated piRNAs expressed in somatic non-gonadal tissues. Communications Biology, 2018, 1, art.nro. 2. doi: 10.1038/s42003-017-0001-7 2399-3642 https://hdl.handle.net/20.500.12008/22005 10.1038/s42003-017-0001-7 |
| dc.language.none.fl_str_mv | en eng |
| dc.publisher.none.fl_str_mv | Nature Publishing Group |
| dc.relation.none.fl_str_mv | Communications Biology, 2018,1 , art. no. 2 |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess Licencia Creative Commons Atribución (CC –BY 4.0) |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.none.fl_str_mv | piRNAs Sequence annotation |
| dc.title.none.fl_str_mv | Non-coding RNA fragments account for themajority of annotated piRNAs expressed in somaticnon-gonadal tissues |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | PIWI-interacting RNAs (piRNAs) are regarded as the guardians of the genome because theytackle genome stability-threatening transposable elements in the germline. Recently, piRNAswere also reported in other types of cells, including mouse brain, malignant and non-malignant somatic tissues, and human plasma. This suggests that piRNA function might bebroader than previously expected. Here, we show that different piRNA databases contain asubset of sequences that correspond to piRNA-sized fragments of ncRNAs (rRNAs, tRNAs,YRNAs, snRNAs, and snoRNAs) and intermediates of miRNA biogenesis. We discuss that thebiogenesis of these sequences is probably independent of the PIWI pathway, and cantherefore be considered contaminants in piRNA databases. Although a minority of annotatedpiRNAs falls in this category, they account for the vast majority of piRNA expression insomatic non-gonadal tissues. Since ncRNA fragments are ubiquitous and abundant, theirconfusion with piRNAs strongly impacts the estimation of piRNA expression outside ofmammalian gonads. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_d4e8c3b921be8bf914674b8958bcd2db |
| identifier_str_mv | Tosar, J.P., Rovira, C.,Cayota, A. Non-coding RNA fragments account for the majority of annotated piRNAs expressed in somatic non-gonadal tissues. Communications Biology, 2018, 1, art.nro. 2. doi: 10.1038/s42003-017-0001-7 2399-3642 10.1038/s42003-017-0001-7 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/22005 |
| publishDate | 2018 |
| publishDateSort | 2018 |
| publisher.none.fl_str_mv | Nature Publishing Group |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC –BY 4.0) |
| spelling | Non-coding RNA fragments account for themajority of annotated piRNAs expressed in somaticnon-gonadal tissuesTosar Rovira, Juan PabloRovira, CarlosCayota, AlfonsopiRNAsSequence annotationPIWI-interacting RNAs (piRNAs) are regarded as the guardians of the genome because theytackle genome stability-threatening transposable elements in the germline. Recently, piRNAswere also reported in other types of cells, including mouse brain, malignant and non-malignant somatic tissues, and human plasma. This suggests that piRNA function might bebroader than previously expected. Here, we show that different piRNA databases contain asubset of sequences that correspond to piRNA-sized fragments of ncRNAs (rRNAs, tRNAs,YRNAs, snRNAs, and snoRNAs) and intermediates of miRNA biogenesis. We discuss that thebiogenesis of these sequences is probably independent of the PIWI pathway, and cantherefore be considered contaminants in piRNA databases. Although a minority of annotatedpiRNAs falls in this category, they account for the vast majority of piRNA expression insomatic non-gonadal tissues. Since ncRNA fragments are ubiquitous and abundant, theirconfusion with piRNAs strongly impacts the estimation of piRNA expression outside ofmammalian gonads.Nature Publishing GroupTosar, Juan Pablo. Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones NuclearesCayota, Alfonso. Instituto Pasteur (Montevideo).2019-10-02T22:08:23Z2019-10-02T22:08:23Z201820190930Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfTosar, J.P., Rovira, C.,Cayota, A. Non-coding RNA fragments account for the majority of annotated piRNAs expressed in somatic non-gonadal tissues. Communications Biology, 2018, 1, art.nro. 2. doi: 10.1038/s42003-017-0001-7 2399-3642https://hdl.handle.net/20.500.12008/2200510.1038/s42003-017-0001-7 reponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaenengCommunications Biology, 2018,1 , art. no. 2Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad De La República. (Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC –BY 4.0)oai:colibri.udelar.edu.uy:20.500.12008/220052026-04-14T10:09:14Z |
| spellingShingle | Non-coding RNA fragments account for themajority of annotated piRNAs expressed in somaticnon-gonadal tissues Tosar Rovira, Juan Pablo piRNAs Sequence annotation |
| status_str | publishedVersion |
| title | Non-coding RNA fragments account for themajority of annotated piRNAs expressed in somaticnon-gonadal tissues |
| title_full | Non-coding RNA fragments account for themajority of annotated piRNAs expressed in somaticnon-gonadal tissues |
| title_fullStr | Non-coding RNA fragments account for themajority of annotated piRNAs expressed in somaticnon-gonadal tissues |
| title_full_unstemmed | Non-coding RNA fragments account for themajority of annotated piRNAs expressed in somaticnon-gonadal tissues |
| title_short | Non-coding RNA fragments account for themajority of annotated piRNAs expressed in somaticnon-gonadal tissues |
| title_sort | Non-coding RNA fragments account for themajority of annotated piRNAs expressed in somaticnon-gonadal tissues |
| topic | piRNAs Sequence annotation |
| url | https://hdl.handle.net/20.500.12008/22005 |