Memory gate controlled by contexts: potential key structure that could link small associative failures with severe cognitive disorders
Can the banal and transient forgetfulness that we all experience at some point in our lives give us clues about the neural mechanisms underlying the onset of severe dementia, such as Alzheimer´s disease (AD)? The hypothesis we propose suggests an affirmative answer. If access to the memory system (M...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , |
| التنسيق: | article |
| اللغة: | الإنجليزية |
| منشور في: |
2025
|
| الموضوعات: | |
| الوصول للمادة أونلاين: | https://hdl.handle.net/20.500.12008/54043 |
| الوسوم: |
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1868890202238353408 |
|---|---|
| author | Mizraji Nathan, Eduardo Jacobo |
| author2 | Lin, Juan Pomi, Andrés |
| author2_role | author author |
| author_browse | Lin, Juan Mizraji Nathan, Eduardo Jacobo Pomi, Andrés |
| author_facet | Mizraji Nathan, Eduardo Jacobo Lin, Juan Pomi, Andrés |
| author_role | author |
| collection | COLIBRI |
| dc.contributor.none.fl_str_mv | Mizraji Nathan Eduardo Jacobo, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. Lin Juan, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. Pomi Andrés, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. |
| dc.creator.none.fl_str_mv | Mizraji Nathan, Eduardo Jacobo Lin, Juan Pomi, Andrés |
| dc.date.none.fl_str_mv | 2025 2026-03-23T16:03:35Z 2026-03-23T16:03:35Z |
| dc.format.none.fl_str_mv | 11 h application/pdf |
| dc.identifier.none.fl_str_mv | Mizraji Nathan, E, Lin, J y Pomi, A. "Memory gate controlled by contexts: potential key structure that could link small associative failures with severe cognitive disorders". BioEssays. [en línea] 2025, 47(8): e70032. 11 h. DOI: 10.1002/bies.70032 1521-1878 https://hdl.handle.net/20.500.12008/54043 10.1002/bies.70032 |
| dc.language.none.fl_str_mv | en eng |
| dc.publisher.none.fl_str_mv | Wiley |
| dc.relation.none.fl_str_mv | BioEssays, 2025, 47(8): e70032. |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess Licencia Creative Commons Atribución - No Comercial (CC - By-NC 4.0) |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.none.fl_str_mv | Alzheimer’s disease Associative contexts network Memory gate Memory recall Transient forgetting |
| dc.title.none.fl_str_mv | Memory gate controlled by contexts: potential key structure that could link small associative failures with severe cognitive disorders |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Can the banal and transient forgetfulness that we all experience at some point in our lives give us clues about the neural mechanisms underlying the onset of severe dementia, such as Alzheimer´s disease (AD)? The hypothesis we propose suggests an affirmative answer. If access to the memory system (MS) depends on matching key input patterns to appropriate contexts, we postulate that if the matching does not occur, the MS is blocked by a neural gate. From empirical observations, we shift to neural models of memories and their modulation by contexts. Our approach provides a possible explanation for transient memory failures but also suggests that the memory gate (MG) can be a crucial neural module that triggers a cascade of events leading to conditions where AD becomes irreversible and catastrophic. This hypothesis suggests ways to slow down the progression of this disease and may be explored with currently available techniques. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_d4bdfc45e13a7f80f1f85eaa46a823a2 |
| identifier_str_mv | Mizraji Nathan, E, Lin, J y Pomi, A. "Memory gate controlled by contexts: potential key structure that could link small associative failures with severe cognitive disorders". BioEssays. [en línea] 2025, 47(8): e70032. 11 h. DOI: 10.1002/bies.70032 1521-1878 10.1002/bies.70032 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/54043 |
| publishDate | 2025 |
| publishDateSort | 2025 |
| publisher.none.fl_str_mv | Wiley |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Licencia Creative Commons Atribución - No Comercial (CC - By-NC 4.0) |
| spelling | Memory gate controlled by contexts: potential key structure that could link small associative failures with severe cognitive disordersMizraji Nathan, Eduardo JacoboLin, JuanPomi, AndrésAlzheimer’s diseaseAssociative contexts networkMemory gateMemory recallTransient forgettingCan the banal and transient forgetfulness that we all experience at some point in our lives give us clues about the neural mechanisms underlying the onset of severe dementia, such as Alzheimer´s disease (AD)? The hypothesis we propose suggests an affirmative answer. If access to the memory system (MS) depends on matching key input patterns to appropriate contexts, we postulate that if the matching does not occur, the MS is blocked by a neural gate. From empirical observations, we shift to neural models of memories and their modulation by contexts. Our approach provides a possible explanation for transient memory failures but also suggests that the memory gate (MG) can be a crucial neural module that triggers a cascade of events leading to conditions where AD becomes irreversible and catastrophic. This hypothesis suggests ways to slow down the progression of this disease and may be explored with currently available techniques.WileyMizraji Nathan Eduardo Jacobo, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología.Lin Juan, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología.Pomi Andrés, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología.2026-03-23T16:03:35Z2026-03-23T16:03:35Z2025Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion11 happlication/pdfMizraji Nathan, E, Lin, J y Pomi, A. "Memory gate controlled by contexts: potential key structure that could link small associative failures with severe cognitive disorders". BioEssays. [en línea] 2025, 47(8): e70032. 11 h. DOI: 10.1002/bies.700321521-1878https://hdl.handle.net/20.500.12008/5404310.1002/bies.70032reponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaenengBioEssays, 2025, 47(8): e70032.Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución - No Comercial (CC - By-NC 4.0)oai:colibri.udelar.edu.uy:20.500.12008/540432026-04-14T10:11:00Z |
| spellingShingle | Memory gate controlled by contexts: potential key structure that could link small associative failures with severe cognitive disorders Mizraji Nathan, Eduardo Jacobo Alzheimer’s disease Associative contexts network Memory gate Memory recall Transient forgetting |
| status_str | publishedVersion |
| title | Memory gate controlled by contexts: potential key structure that could link small associative failures with severe cognitive disorders |
| title_full | Memory gate controlled by contexts: potential key structure that could link small associative failures with severe cognitive disorders |
| title_fullStr | Memory gate controlled by contexts: potential key structure that could link small associative failures with severe cognitive disorders |
| title_full_unstemmed | Memory gate controlled by contexts: potential key structure that could link small associative failures with severe cognitive disorders |
| title_short | Memory gate controlled by contexts: potential key structure that could link small associative failures with severe cognitive disorders |
| title_sort | Memory gate controlled by contexts: potential key structure that could link small associative failures with severe cognitive disorders |
| topic | Alzheimer’s disease Associative contexts network Memory gate Memory recall Transient forgetting |
| url | https://hdl.handle.net/20.500.12008/54043 |