Across intra-mammalian stages of the liver f luke Fasciola hepatica: a proteomic study
Fasciola hepatica is the agent of fasciolosis, a foodborne zoonosis that affects livestock production and human health. Although flukicidal drugs are available, re-infection and expanding resistance to triclabendazole demand new control strategies. Understanding the molecular mechanisms underlying t...
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| Format: | article |
| Language: | English |
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2016
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| Online Access: | https://hdl.handle.net/20.500.12008/22008 |
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| _version_ | 1868890188730597376 |
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| author | Sánchez Di Maggio, Lucía |
| author2 | Tirloni, L. Pinto, A.F.M. Diedrich, J.K. Yates, J.R. Benavides, Uruguaysito Carmona García, Carlos Da Silva Vaz, Itabajara Berasain, Patricia |
| author2_role | author author author author author author author author |
| author_browse | Benavides, Uruguaysito Berasain, Patricia Carmona García, Carlos Da Silva Vaz, Itabajara Diedrich, J.K. Pinto, A.F.M. Sánchez Di Maggio, Lucía Tirloni, L. Yates, J.R. |
| author_facet | Sánchez Di Maggio, Lucía Tirloni, L. Pinto, A.F.M. Diedrich, J.K. Yates, J.R. Benavides, Uruguaysito Carmona García, Carlos Da Silva Vaz, Itabajara Berasain, Patricia |
| author_role | author |
| collection | COLIBRI |
| dc.contributor.none.fl_str_mv | Sánchez Di Maggio, Lucía. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología Benavides, Uruguaysito. Universidad de la República (Uruguay). Facultad de Veterinaria Carmona Garcia, Carlos. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. Berasain, Patricia. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. |
| dc.creator.none.fl_str_mv | Sánchez Di Maggio, Lucía Tirloni, L. Pinto, A.F.M. Diedrich, J.K. Yates, J.R. Benavides, Uruguaysito Carmona García, Carlos Da Silva Vaz, Itabajara Berasain, Patricia |
| dc.date.none.fl_str_mv | 2016 2019-10-02T22:08:25Z 2019-10-02T22:08:25Z 20190930 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Sánchez Di Maggio, L., et al. "Across intra-mammalian stages of the liver f luke Fasciola hepatica: a proteomic study". Scientific Reports, 2016, 6, art. nro. 32796. doi: 10.1038/srep32796 2045-2322 https://hdl.handle.net/20.500.12008/22008 10.1038/srep32796 |
| dc.language.none.fl_str_mv | en eng |
| dc.publisher.none.fl_str_mv | Nature Publishing Group |
| dc.relation.none.fl_str_mv | Scientific Reports, 2016, 6, art. no. 32796 |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess Licencia Creative Commons Atribución (CC –BY 4.0) |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.none.fl_str_mv | Helminth protein Fasciola hepatica Gene expression regulation |
| dc.title.none.fl_str_mv | Across intra-mammalian stages of the liver f luke Fasciola hepatica: a proteomic study |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Fasciola hepatica is the agent of fasciolosis, a foodborne zoonosis that affects livestock production and human health. Although flukicidal drugs are available, re-infection and expanding resistance to triclabendazole demand new control strategies. Understanding the molecular mechanisms underlying the complex interaction with the mammalian host could provide relevant clues, aiding the search for novel targets in diagnosis and control of fasciolosis. Parasite survival in the mammalian host is mediated by parasite compounds released during infection, known as excretory/secretory (E/S) products. E/S products are thought to protect parasites from host responses, allowing them to survive for a long period in the vertebrate host. This work provides in-depth proteomic analysis of F. hepatica intra-mammalian stages, and represents the largest number of proteins identified to date for this species. Functional classification revealed the presence of proteins involved in different biological processes, many of which represent original findings for this organism and are important for parasite survival within the host. These results could lead to a better comprehension of host-parasite relationships, and contribute to the development of drugs or vaccines against this parasite. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_c6c7a65e996cdc6ef8aee8358116852d |
| identifier_str_mv | Sánchez Di Maggio, L., et al. "Across intra-mammalian stages of the liver f luke Fasciola hepatica: a proteomic study". Scientific Reports, 2016, 6, art. nro. 32796. doi: 10.1038/srep32796 2045-2322 10.1038/srep32796 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/22008 |
| publishDate | 2016 |
| publishDateSort | 2016 |
| publisher.none.fl_str_mv | Nature Publishing Group |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC –BY 4.0) |
| spelling | Across intra-mammalian stages of the liver f luke Fasciola hepatica: a proteomic studySánchez Di Maggio, LucíaTirloni, L.Pinto, A.F.M.Diedrich, J.K.Yates, J.R.Benavides, UruguaysitoCarmona García, CarlosDa Silva Vaz, ItabajaraBerasain, PatriciaHelminth proteinFasciola hepaticaGene expression regulationFasciola hepatica is the agent of fasciolosis, a foodborne zoonosis that affects livestock production and human health. Although flukicidal drugs are available, re-infection and expanding resistance to triclabendazole demand new control strategies. Understanding the molecular mechanisms underlying the complex interaction with the mammalian host could provide relevant clues, aiding the search for novel targets in diagnosis and control of fasciolosis. Parasite survival in the mammalian host is mediated by parasite compounds released during infection, known as excretory/secretory (E/S) products. E/S products are thought to protect parasites from host responses, allowing them to survive for a long period in the vertebrate host. This work provides in-depth proteomic analysis of F. hepatica intra-mammalian stages, and represents the largest number of proteins identified to date for this species. Functional classification revealed the presence of proteins involved in different biological processes, many of which represent original findings for this organism and are important for parasite survival within the host. These results could lead to a better comprehension of host-parasite relationships, and contribute to the development of drugs or vaccines against this parasite.Nature Publishing GroupSánchez Di Maggio, Lucía. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de BiologíaBenavides, Uruguaysito. Universidad de la República (Uruguay). Facultad de VeterinariaCarmona Garcia, Carlos. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. Berasain, Patricia. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología.2019-10-02T22:08:25Z2019-10-02T22:08:25Z201620190930Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfSánchez Di Maggio, L., et al. "Across intra-mammalian stages of the liver f luke Fasciola hepatica: a proteomic study". Scientific Reports, 2016, 6, art. nro. 32796. doi: 10.1038/srep327962045-2322https://hdl.handle.net/20.500.12008/2200810.1038/srep32796reponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaenengScientific Reports, 2016, 6, art. no. 32796Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad De La República. (Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC –BY 4.0)oai:colibri.udelar.edu.uy:20.500.12008/220082026-04-14T10:09:14Z |
| spellingShingle | Across intra-mammalian stages of the liver f luke Fasciola hepatica: a proteomic study Sánchez Di Maggio, Lucía Helminth protein Fasciola hepatica Gene expression regulation |
| status_str | publishedVersion |
| title | Across intra-mammalian stages of the liver f luke Fasciola hepatica: a proteomic study |
| title_full | Across intra-mammalian stages of the liver f luke Fasciola hepatica: a proteomic study |
| title_fullStr | Across intra-mammalian stages of the liver f luke Fasciola hepatica: a proteomic study |
| title_full_unstemmed | Across intra-mammalian stages of the liver f luke Fasciola hepatica: a proteomic study |
| title_short | Across intra-mammalian stages of the liver f luke Fasciola hepatica: a proteomic study |
| title_sort | Across intra-mammalian stages of the liver f luke Fasciola hepatica: a proteomic study |
| topic | Helminth protein Fasciola hepatica Gene expression regulation |
| url | https://hdl.handle.net/20.500.12008/22008 |