Molecular profile of gastric adenocarcinoma and the gastroesophageal junction
Gastric cancer is one of the most common malignant tumors of the digestive tract. In our setting, it generally presents at advanced stages. In these patients, advances in histopathological and molecular characterization have led to the implementation of targeted therapies. The combination with chemo...
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| Format: | article |
| Sprache: | Spanisch Englisch Portugiesisch |
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2026
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| Online-Zugang: | https://revista.scu.org.uy/index.php/cir_urug/article/view/5925 |
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| Zusammenfassung: | Gastric cancer is one of the most common malignant tumors of the digestive tract. In our setting, it generally presents at advanced stages. In these patients, advances in histopathological and molecular characterization have led to the implementation of targeted therapies. The combination with chemotherapy has demonstrated a significant increase in survival in patients with disseminated disease. Objective: To perform an epidemiological, clinical, pathological, and molecular description of gastric and gastroesophageal junction tumors in a retrospective cohort from January 1, 2019, to October 31, 2024, at the Hospital de Clínicas, Montevideo, Uruguay. Methodology: A descriptive, observational, and retrospective study was conducted over a 5-year period. Data were collected from all patients diagnosed and treated for gastric cancer at the Hospital de Clínicas Dr. Manuel Quíntela, whose records were archived in the Department of Pathology. Results: A sample of 59 patients was obtained. PD-L1 was analyzed in 26 of them, with 10 positive and 16 negative results. Her2/neu expression was obtained in 49 patients, with 28 having a score of 0, 4 Her2/neu +, 9 Her2/neu ++, and 8 Her2/neu +++.Microsatellite instability (MSI) was analyzed in 34 patients; 10 presented with MSI-H/dMMR and 24 with a low probability of MSI. Conclusions: Molecular and epidemiological characterization of patients with gastric adenocarcinoma and gastroesophageal junction cancer was achieved. This is the first study in Uruguay to molecularly characterize these tumors in order to develop targeted cancer therapies for each molecular subtype (onco-specific). |
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