Muscular remodeling and anteroposterior patterning during tapeworm segmentation
Background: Tapeworms are parasitic flatworms that independently evolved a segmented body plan, historically confounding comparisons with other animals. Anteroposterior (AP) patterning in free-living flatworms and in tapeworm larvae is associated with canonical Wnt signaling and positional control g...
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| Andre forfattere: | , , , , |
| Format: | article |
| Sprog: | engelsk |
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2024
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| Online adgang: | https://hdl.handle.net/20.500.12008/50158 |
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| _version_ | 1868890178940043264 |
|---|---|
| author | Jarero, F. |
| author2 | Baillie, Andrew Riddiford, Nick Montagne, Jimena Koziol, Uriel Olson, P.D. |
| author2_role | author author author author author |
| author_browse | Baillie, Andrew Jarero, F. Koziol, Uriel Montagne, Jimena Olson, P.D. Riddiford, Nick |
| author_facet | Jarero, F. Baillie, Andrew Riddiford, Nick Montagne, Jimena Koziol, Uriel Olson, P.D. |
| author_role | author |
| collection | COLIBRI |
| dc.contributor.none.fl_str_mv | Jarero F. Baillie Andrew Riddiford Nick Montagne Jimena, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. Koziol Uriel, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. Olson P.D. |
| dc.creator.none.fl_str_mv | Jarero, F. Baillie, Andrew Riddiford, Nick Montagne, Jimena Koziol, Uriel Olson, P.D. |
| dc.date.none.fl_str_mv | 2024 2025-05-28T17:41:14Z 2025-05-28T17:41:14Z |
| dc.format.none.fl_str_mv | 26 h application/pdf |
| dc.identifier.none.fl_str_mv | Jarero, F, Baillie, A, Riddiford, N [y otros autores]. "Muscular remodeling and anteroposterior patterning during tapeworm segmentation". Developmental Dynamics. [en línea] 2024, 253(11): 998-1023. 26 h. DOI: 10.1002/dvdy.712 1097-0177 https://hdl.handle.net/20.500.12008/50158 10.1002/dvdy.712 |
| dc.language.none.fl_str_mv | en eng |
| dc.publisher.none.fl_str_mv | Wiley |
| dc.relation.none.fl_str_mv | Developmental Dynamics, 2024, 253(11): 998-1023. |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess Licencia Creative Commons Atribución (CC - By 4.0) |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.none.fl_str_mv | Anteroposterior patterning Cestoda Hedgehog Platyhelminthes Positional control genes Wnt |
| dc.title.none.fl_str_mv | Muscular remodeling and anteroposterior patterning during tapeworm segmentation |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Background: Tapeworms are parasitic flatworms that independently evolved a segmented body plan, historically confounding comparisons with other animals. Anteroposterior (AP) patterning in free-living flatworms and in tapeworm larvae is associated with canonical Wnt signaling and positional control genes (PCGs) are expressed by their musculature in regionalized domains along the AP axis. Here, we extend investigations of PCG expression to the adult of the mouse bile-duct tapeworm Hymenolepis microstoma, focusing on the growth zone of the neck region and the initial establishment of segmental patterning. Results: We show that the adult musculature includes new, segmental elements that first appear in the neck and that the spatial patterns of Wnt factors are consistent with expression by muscle cells. Wnt factor expression is highly regionalized and becomes AP-polarized in segments, marking them with axes in agreement with the polarity of the main body axis, while the transition between the neck and strobila is specifically demarcated by the expression domain of a Wnt11 paralog. Conclusion: We suggest that segmentation could originate in the muscular system and participate in patterning the AP axis through regional and polarized expression of PCGs, akin to the gene regulatory networks employed by free-living flatworms and other animals. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_bdce0bf1d451235ac830efc3ca46a9ee |
| identifier_str_mv | Jarero, F, Baillie, A, Riddiford, N [y otros autores]. "Muscular remodeling and anteroposterior patterning during tapeworm segmentation". Developmental Dynamics. [en línea] 2024, 253(11): 998-1023. 26 h. DOI: 10.1002/dvdy.712 1097-0177 10.1002/dvdy.712 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/50158 |
| publishDate | 2024 |
| publishDateSort | 2024 |
| publisher.none.fl_str_mv | Wiley |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| spelling | Muscular remodeling and anteroposterior patterning during tapeworm segmentationJarero, F.Baillie, AndrewRiddiford, NickMontagne, JimenaKoziol, UrielOlson, P.D.Anteroposterior patterningCestodaHedgehogPlatyhelminthesPositional control genesWntBackground: Tapeworms are parasitic flatworms that independently evolved a segmented body plan, historically confounding comparisons with other animals. Anteroposterior (AP) patterning in free-living flatworms and in tapeworm larvae is associated with canonical Wnt signaling and positional control genes (PCGs) are expressed by their musculature in regionalized domains along the AP axis. Here, we extend investigations of PCG expression to the adult of the mouse bile-duct tapeworm Hymenolepis microstoma, focusing on the growth zone of the neck region and the initial establishment of segmental patterning. Results: We show that the adult musculature includes new, segmental elements that first appear in the neck and that the spatial patterns of Wnt factors are consistent with expression by muscle cells. Wnt factor expression is highly regionalized and becomes AP-polarized in segments, marking them with axes in agreement with the polarity of the main body axis, while the transition between the neck and strobila is specifically demarcated by the expression domain of a Wnt11 paralog. Conclusion: We suggest that segmentation could originate in the muscular system and participate in patterning the AP axis through regional and polarized expression of PCGs, akin to the gene regulatory networks employed by free-living flatworms and other animals.WileyJarero F.Baillie AndrewRiddiford NickMontagne Jimena, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología.Koziol Uriel, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología.Olson P.D.2025-05-28T17:41:14Z2025-05-28T17:41:14Z2024Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion26 happlication/pdfJarero, F, Baillie, A, Riddiford, N [y otros autores]. "Muscular remodeling and anteroposterior patterning during tapeworm segmentation". Developmental Dynamics. [en línea] 2024, 253(11): 998-1023. 26 h. DOI: 10.1002/dvdy.7121097-0177https://hdl.handle.net/20.500.12008/5015810.1002/dvdy.712reponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaenengDevelopmental Dynamics, 2024, 253(11): 998-1023.Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC - By 4.0)oai:colibri.udelar.edu.uy:20.500.12008/501582026-04-14T10:10:50Z |
| spellingShingle | Muscular remodeling and anteroposterior patterning during tapeworm segmentation Jarero, F. Anteroposterior patterning Cestoda Hedgehog Platyhelminthes Positional control genes Wnt |
| status_str | publishedVersion |
| title | Muscular remodeling and anteroposterior patterning during tapeworm segmentation |
| title_full | Muscular remodeling and anteroposterior patterning during tapeworm segmentation |
| title_fullStr | Muscular remodeling and anteroposterior patterning during tapeworm segmentation |
| title_full_unstemmed | Muscular remodeling and anteroposterior patterning during tapeworm segmentation |
| title_short | Muscular remodeling and anteroposterior patterning during tapeworm segmentation |
| title_sort | Muscular remodeling and anteroposterior patterning during tapeworm segmentation |
| topic | Anteroposterior patterning Cestoda Hedgehog Platyhelminthes Positional control genes Wnt |
| url | https://hdl.handle.net/20.500.12008/50158 |