Effect of pegbovigrastim on fertility and culling in grazing dairy cows and its association with prepartum nonesterified fatty acids
This randomized controlled trial on 4 commercial grazing dairy farms investigated whether treatment with pegbovigrastim (PEG) affected fertility and culling as measured during the full lactation. We also explored the effect of potential interactions of PEG treatment with parity, prepartum body condi...
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| Format: | article |
| Idioma: | anglès |
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2021
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| Accés en línia: | https://hdl.handle.net/20.500.12008/48234 https://doi.org/10.3168/jds.2021-20785 |
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| _version_ | 1868890177585283072 |
|---|---|
| author | Barca Tarigo, Joaquín |
| author2 | Meikle, Ana Bouman, Mette Schukken, Ynte Hein |
| author2_role | author author author |
| author_browse | Barca Tarigo, Joaquín Bouman, Mette Meikle, Ana Schukken, Ynte Hein |
| author_facet | Barca Tarigo, Joaquín Meikle, Ana Bouman, Mette Schukken, Ynte Hein |
| author_role | author |
| collection | COLIBRI |
| dc.contributor.none.fl_str_mv | Barca Tarigo Joaquín, Universidad de la República (Uruguay). Veterinary Faculty. Department of Dairy Science and Technology; Wageningen University (Wageningen, The Netherlands). Department of Animal Sciences Meikle Ana, Universidad de la República (Uruguay). Veterinary Faculty. Animal Endocrine and Metabolism Laboratory Bouman Mette, Veterinary Practitioner (Colonia, Uruguay) Schukken Ynte Hein, Wageningen University (Wageningen, The Netherlands). Department of Animal Sciences; Royal GD (Deventer, The Netherlands) |
| dc.creator.none.fl_str_mv | Barca Tarigo, Joaquín Meikle, Ana Bouman, Mette Schukken, Ynte Hein |
| dc.date.none.fl_str_mv | 2021 2025-02-06T17:11:21Z 2025-02-06T17:11:21Z |
| dc.format.none.fl_str_mv | 16 p application/pdf |
| dc.identifier.none.fl_str_mv | Barca Tarigo, J, Meikle, A, Bouman, M y Schukken, Y. Effect of pegbovigrastim on fertility and culling in grazing dairy cows and its association with prepartum nonesterified fatty acids. Journal of Dairy Science. [en línea] 2021, 105, 710–725 https://hdl.handle.net/20.500.12008/48234 https://doi.org/10.3168/jds.2021-20785 |
| dc.language.none.fl_str_mv | en eng |
| dc.relation.none.fl_str_mv | Journal of Dairy Science, 2021, 105, 710–725 |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess Licencia Creative Commons Atribución (CC - By 4.0) |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.none.fl_str_mv | VACAS LECHERAS PASTOREO ACIDOS GRASOS FERTILIDAD |
| dc.title.none.fl_str_mv | Effect of pegbovigrastim on fertility and culling in grazing dairy cows and its association with prepartum nonesterified fatty acids |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | This randomized controlled trial on 4 commercial grazing dairy farms investigated whether treatment with pegbovigrastim (PEG) affected fertility and culling as measured during the full lactation. We also explored the effect of potential interactions of PEG treatment with parity, prepartum body condition score, prepartum nonesterified fatty acid concentration (pre-NEFA), and early-lactation clinical disease on these outcomes. Holstein cows were randomly assigned to 1 of 2 trial arms: a first PEG dose approximately 7 d before the expected calving date and a second dose within 24 h after calving (PEG: primiparous = 342; multiparous = 697) compared with untreated controls (control: primiparous = 391; multiparous = 723). Cox’s proportional hazards regression models were used to analyze rate of first insemination, rate of pregnancy [within 150 and 305 d in milk (DIM)], and hazard of culling. Additional analyses were performed on data that were stratified by parity group and pre-NEFA class (low ≤0.3; high >0.3 mM). In high pre-NEFA cows, PEG treatment increased the rate of first insemination [hazard ratio (HR) = 1.15]. Early-lactation clinical mastitis (CM) and uterine disease (UD: retained placenta, metritis, or both) were associated with a reduced rate of pregnancy within 150 DIM (HR = 0.49 and 0.78, respectively). Pegbovigrastim treatment in high pre-NEFA cows with CM and UD increased the rate of pregnancy within 150 DIM (HR = 1.75 and 1.46, respectively). In high pre-NEFA cows, PEG treatment resulted in a lower hazard of culling (HR = 0.79). No treatment effect was detected in low pre-NEFA cows. This study shows that the effect of PEG treatment on fertility and culling interacts with pre-NEFA. In high pre-NEFA cows, PEG treatment increased the rate of first insemination, counteracted the negative association of early-lactation CM and UD with the rate of pregnancy, and decreased the hazard of culling. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_bc4519cb2d9fded7b7a7c050fc876819 |
| identifier_str_mv | Barca Tarigo, J, Meikle, A, Bouman, M y Schukken, Y. Effect of pegbovigrastim on fertility and culling in grazing dairy cows and its association with prepartum nonesterified fatty acids. Journal of Dairy Science. [en línea] 2021, 105, 710–725 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/48234 |
| publishDate | 2021 |
| publishDateSort | 2021 |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| spelling | Effect of pegbovigrastim on fertility and culling in grazing dairy cows and its association with prepartum nonesterified fatty acidsBarca Tarigo, JoaquínMeikle, AnaBouman, MetteSchukken, Ynte HeinVACAS LECHERASPASTOREOACIDOS GRASOSFERTILIDADThis randomized controlled trial on 4 commercial grazing dairy farms investigated whether treatment with pegbovigrastim (PEG) affected fertility and culling as measured during the full lactation. We also explored the effect of potential interactions of PEG treatment with parity, prepartum body condition score, prepartum nonesterified fatty acid concentration (pre-NEFA), and early-lactation clinical disease on these outcomes. Holstein cows were randomly assigned to 1 of 2 trial arms: a first PEG dose approximately 7 d before the expected calving date and a second dose within 24 h after calving (PEG: primiparous = 342; multiparous = 697) compared with untreated controls (control: primiparous = 391; multiparous = 723). Cox’s proportional hazards regression models were used to analyze rate of first insemination, rate of pregnancy [within 150 and 305 d in milk (DIM)], and hazard of culling. Additional analyses were performed on data that were stratified by parity group and pre-NEFA class (low ≤0.3; high >0.3 mM). In high pre-NEFA cows, PEG treatment increased the rate of first insemination [hazard ratio (HR) = 1.15]. Early-lactation clinical mastitis (CM) and uterine disease (UD: retained placenta, metritis, or both) were associated with a reduced rate of pregnancy within 150 DIM (HR = 0.49 and 0.78, respectively). Pegbovigrastim treatment in high pre-NEFA cows with CM and UD increased the rate of pregnancy within 150 DIM (HR = 1.75 and 1.46, respectively). In high pre-NEFA cows, PEG treatment resulted in a lower hazard of culling (HR = 0.79). No treatment effect was detected in low pre-NEFA cows. This study shows that the effect of PEG treatment on fertility and culling interacts with pre-NEFA. In high pre-NEFA cows, PEG treatment increased the rate of first insemination, counteracted the negative association of early-lactation CM and UD with the rate of pregnancy, and decreased the hazard of culling.Barca Tarigo Joaquín, Universidad de la República (Uruguay). Veterinary Faculty. Department of Dairy Science and Technology; Wageningen University (Wageningen, The Netherlands). Department of Animal SciencesMeikle Ana, Universidad de la República (Uruguay). Veterinary Faculty. Animal Endocrine and Metabolism LaboratoryBouman Mette, Veterinary Practitioner (Colonia, Uruguay)Schukken Ynte Hein, Wageningen University (Wageningen, The Netherlands). Department of Animal Sciences; Royal GD (Deventer, The Netherlands)2025-02-06T17:11:21Z2025-02-06T17:11:21Z2021Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion16 papplication/pdfBarca Tarigo, J, Meikle, A, Bouman, M y Schukken, Y. Effect of pegbovigrastim on fertility and culling in grazing dairy cows and its association with prepartum nonesterified fatty acids. Journal of Dairy Science. [en línea] 2021, 105, 710–725https://hdl.handle.net/20.500.12008/48234https://doi.org/10.3168/jds.2021-20785reponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaenengJournal of Dairy Science, 2021, 105, 710–725Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC - By 4.0)oai:colibri.udelar.edu.uy:20.500.12008/482342026-04-14T10:35:05Z |
| spellingShingle | Effect of pegbovigrastim on fertility and culling in grazing dairy cows and its association with prepartum nonesterified fatty acids Barca Tarigo, Joaquín VACAS LECHERAS PASTOREO ACIDOS GRASOS FERTILIDAD |
| status_str | publishedVersion |
| title | Effect of pegbovigrastim on fertility and culling in grazing dairy cows and its association with prepartum nonesterified fatty acids |
| title_full | Effect of pegbovigrastim on fertility and culling in grazing dairy cows and its association with prepartum nonesterified fatty acids |
| title_fullStr | Effect of pegbovigrastim on fertility and culling in grazing dairy cows and its association with prepartum nonesterified fatty acids |
| title_full_unstemmed | Effect of pegbovigrastim on fertility and culling in grazing dairy cows and its association with prepartum nonesterified fatty acids |
| title_short | Effect of pegbovigrastim on fertility and culling in grazing dairy cows and its association with prepartum nonesterified fatty acids |
| title_sort | Effect of pegbovigrastim on fertility and culling in grazing dairy cows and its association with prepartum nonesterified fatty acids |
| topic | VACAS LECHERAS PASTOREO ACIDOS GRASOS FERTILIDAD |
| url | https://hdl.handle.net/20.500.12008/48234 https://doi.org/10.3168/jds.2021-20785 |