Detection of Vancomycin Resistance among Methicillin-Resistant Staphylococcus aureus Strains Recovered from Children with Invasive Diseases in a Reference Pediatric Hospital
Vancomycin is the cornerstone in treating methicillin-resistant Staphylococcus aureus (MRSA) infections. However, therapeutic failures can occur when MRSA strains with decreased susceptibility to glycopeptides (DSG) are involved. The aim of this study was to detect and characterize DSG in MRSArecove...
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| مؤلفون آخرون: | , , , , |
| التنسيق: | article |
| اللغة: | الإنجليزية |
| منشور في: |
2024
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://hdl.handle.net/20.500.12008/52464 |
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| _version_ | 1868890175105400832 |
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| author | Pardo, Lorena |
| author2 | Mota, María Inés Parnizari, Andrés Varela, Adriana Algorta, Gabriela Varela, Gustavo |
| author2_role | author author author author author |
| author_browse | Algorta, Gabriela Mota, María Inés Pardo, Lorena Parnizari, Andrés Varela, Adriana Varela, Gustavo |
| author_facet | Pardo, Lorena Mota, María Inés Parnizari, Andrés Varela, Adriana Algorta, Gabriela Varela, Gustavo |
| author_role | author |
| collection | COLIBRI |
| dc.contributor.none.fl_str_mv | Pardo Lorena, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Bacteriología y Virología Mota María Inés, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Bacteriología y Virología Parnizari Andrés, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Bacteriología y Virología Varela Adriana, Administración de los Servicios de Salud del Estado (ASSE) (Uruguay). Centro Hospitalario Pereira Rossell. Laboratorio Bacteriología Algorta Gabriela, Administración de los Servicios de Salud del Estado (ASSE) (Uruguay). Centro Hospitalario Pereira Rossell. Laboratorio Bacteriología Varela Gustavo, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Bacteriología y Virología |
| dc.creator.none.fl_str_mv | Pardo, Lorena Mota, María Inés Parnizari, Andrés Varela, Adriana Algorta, Gabriela Varela, Gustavo |
| dc.date.none.fl_str_mv | 2024 2025-11-14T15:41:32Z 2025-11-14T15:41:32Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | PARDO, L., MOTA, MI., PARNIZARI, A., y otros. Detection of Vancomycin Resistance among Methicillin-Resistant Staphylococcus aureus Strains Recovered from Children with Invasive Diseases in a Reference Pediatric Hospital. Antibiotics [en línea] 2024, 13. DOI: 10.3390/antibiotics13040298 https://hdl.handle.net/20.500.12008/52464 10.3390/antibiotics13040298 |
| dc.language.none.fl_str_mv | en eng |
| dc.relation.none.fl_str_mv | Antibiotics. 13, 2024 |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess Licencia Creative Commons Atribución (CC - By 4.0) |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.none.fl_str_mv | S. aureus vancomycin resistance methicillin-resistant Staphylococcus aureus hVISA |
| dc.title.none.fl_str_mv | Detection of Vancomycin Resistance among Methicillin-Resistant Staphylococcus aureus Strains Recovered from Children with Invasive Diseases in a Reference Pediatric Hospital |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Vancomycin is the cornerstone in treating methicillin-resistant Staphylococcus aureus (MRSA) infections. However, therapeutic failures can occur when MRSA strains with decreased susceptibility to glycopeptides (DSG) are involved. The aim of this study was to detect and characterize DSG in MRSArecovered from children with invasive diseases at a reference pediatric hospital between 2009 and2019. Fifty-two MRSAstrains werescreenedusingagarplates with vancomycin3 and 4 mg/L (BHI-3 and BHI-4); the VITEK2 system; and standard and macro E-tests. Suspicious hVISA were studied by population analysis profiling–area under the curve (PAP-AUC), and wall thickness was analyzed by transmission electron microscopy. Neither VRSA nor VISA were detected in this set. As only three strains met the hVISA criteria, the PAP-AUC study included 12 additional MRSA strains that grew one colony on BHI-4 plates or showed minimum inhibitory concentrations of vancomycin and/or teicoplanin 1.5 mg/L. One strain was confirmed as hVISA by PAP-AUC. The wall thickness was greater than the vancomycin-susceptible control strain; it belonged to ST30 and carried SCCmec IV. As expected, a low frequency of hVISA was found (1.9%). The only hVISA confirmed by PAP-AUC wasnot detected by the screening methods, highlighting the challenge that its detection represents for microbiology laboratories. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_b889c3ed9e4b1f46e86bb2ba6356ea3a |
| identifier_str_mv | PARDO, L., MOTA, MI., PARNIZARI, A., y otros. Detection of Vancomycin Resistance among Methicillin-Resistant Staphylococcus aureus Strains Recovered from Children with Invasive Diseases in a Reference Pediatric Hospital. Antibiotics [en línea] 2024, 13. DOI: 10.3390/antibiotics13040298 10.3390/antibiotics13040298 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/52464 |
| publishDate | 2024 |
| publishDateSort | 2024 |
| reponame_str | COLIBRI |
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| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| spelling | Detection of Vancomycin Resistance among Methicillin-Resistant Staphylococcus aureus Strains Recovered from Children with Invasive Diseases in a Reference Pediatric HospitalPardo, LorenaMota, María InésParnizari, AndrésVarela, AdrianaAlgorta, GabrielaVarela, GustavoS. aureusvancomycin resistancemethicillin-resistant Staphylococcus aureushVISAVancomycin is the cornerstone in treating methicillin-resistant Staphylococcus aureus (MRSA) infections. However, therapeutic failures can occur when MRSA strains with decreased susceptibility to glycopeptides (DSG) are involved. The aim of this study was to detect and characterize DSG in MRSArecovered from children with invasive diseases at a reference pediatric hospital between 2009 and2019. Fifty-two MRSAstrains werescreenedusingagarplates with vancomycin3 and 4 mg/L (BHI-3 and BHI-4); the VITEK2 system; and standard and macro E-tests. Suspicious hVISA were studied by population analysis profiling–area under the curve (PAP-AUC), and wall thickness was analyzed by transmission electron microscopy. Neither VRSA nor VISA were detected in this set. As only three strains met the hVISA criteria, the PAP-AUC study included 12 additional MRSA strains that grew one colony on BHI-4 plates or showed minimum inhibitory concentrations of vancomycin and/or teicoplanin 1.5 mg/L. One strain was confirmed as hVISA by PAP-AUC. The wall thickness was greater than the vancomycin-susceptible control strain; it belonged to ST30 and carried SCCmec IV. As expected, a low frequency of hVISA was found (1.9%). The only hVISA confirmed by PAP-AUC wasnot detected by the screening methods, highlighting the challenge that its detection represents for microbiology laboratories.Comisión Sectorial de Investigación Científica (CSIC)Pardo Lorena, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Bacteriología y VirologíaMota María Inés, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Bacteriología y VirologíaParnizari Andrés, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Bacteriología y VirologíaVarela Adriana, Administración de los Servicios de Salud del Estado (ASSE) (Uruguay). Centro Hospitalario Pereira Rossell. Laboratorio BacteriologíaAlgorta Gabriela, Administración de los Servicios de Salud del Estado (ASSE) (Uruguay). Centro Hospitalario Pereira Rossell. Laboratorio BacteriologíaVarela Gustavo, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Bacteriología y Virología2025-11-14T15:41:32Z2025-11-14T15:41:32Z2024Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfPARDO, L., MOTA, MI., PARNIZARI, A., y otros. Detection of Vancomycin Resistance among Methicillin-Resistant Staphylococcus aureus Strains Recovered from Children with Invasive Diseases in a Reference Pediatric Hospital. Antibiotics [en línea] 2024, 13. DOI: 10.3390/antibiotics13040298https://hdl.handle.net/20.500.12008/5246410.3390/antibiotics13040298reponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaenengAntibiotics. 13, 2024Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC - By 4.0)oai:colibri.udelar.edu.uy:20.500.12008/524642026-04-14T10:37:06Z |
| spellingShingle | Detection of Vancomycin Resistance among Methicillin-Resistant Staphylococcus aureus Strains Recovered from Children with Invasive Diseases in a Reference Pediatric Hospital Pardo, Lorena S. aureus vancomycin resistance methicillin-resistant Staphylococcus aureus hVISA |
| status_str | publishedVersion |
| title | Detection of Vancomycin Resistance among Methicillin-Resistant Staphylococcus aureus Strains Recovered from Children with Invasive Diseases in a Reference Pediatric Hospital |
| title_full | Detection of Vancomycin Resistance among Methicillin-Resistant Staphylococcus aureus Strains Recovered from Children with Invasive Diseases in a Reference Pediatric Hospital |
| title_fullStr | Detection of Vancomycin Resistance among Methicillin-Resistant Staphylococcus aureus Strains Recovered from Children with Invasive Diseases in a Reference Pediatric Hospital |
| title_full_unstemmed | Detection of Vancomycin Resistance among Methicillin-Resistant Staphylococcus aureus Strains Recovered from Children with Invasive Diseases in a Reference Pediatric Hospital |
| title_short | Detection of Vancomycin Resistance among Methicillin-Resistant Staphylococcus aureus Strains Recovered from Children with Invasive Diseases in a Reference Pediatric Hospital |
| title_sort | Detection of Vancomycin Resistance among Methicillin-Resistant Staphylococcus aureus Strains Recovered from Children with Invasive Diseases in a Reference Pediatric Hospital |
| topic | S. aureus vancomycin resistance methicillin-resistant Staphylococcus aureus hVISA |
| url | https://hdl.handle.net/20.500.12008/52464 |