Lipoprotein lipase expression in chronic lymphocytic leukemia: New insights into leukemic progression
Lipoprotein lipase (LPL) is a central enzyme in lipid metabolism. Due to its catalytic activity, LPL is involved in metabolic pathways exploited by various solid and hematologic malignancies to provide an extra energy source to the tumor cell. We and others described a link between the expression of...
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| Format: | article |
| Sprog: | engelsk |
| Udgivet: |
2017
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| Online adgang: | http://hdl.handle.net/20.500.12381/127 https://doi.org/10.3390/molecules22122083 |
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| _version_ | 1868890172985180160 |
|---|---|
| author | Prieto, Daniel |
| author2 | Oppezzo, Pablo |
| author2_role | author |
| author_browse | Oppezzo, Pablo Prieto, Daniel |
| author_facet | Prieto, Daniel Oppezzo, Pablo |
| author_role | author |
| collection | IPMON en REDI |
| dc.creator.none.fl_str_mv | Prieto, Daniel Oppezzo, Pablo |
| dc.date.none.fl_str_mv | 2017 2019-10-15T15:36:43Z 2019-10-15T15:36:43Z |
| dc.format.none.fl_str_mv | 9 p. |
| dc.identifier.none.fl_str_mv | Prieto, D; Oppezzo, P(2017). Lipoprotein Lipase Expression in Chronic Lymphocytic Leukemia: New Insights into Leukemic Progression. Molecules,1-9. http://hdl.handle.net/20.500.12381/127 FMV_2_2011_1_7323 https://doi.org/10.3390/molecules22122083 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | MDPI |
| dc.relation.none.fl_str_mv | Molecules |
| dc.rights.none.fl_str_mv | Acceso abierto info:eu-repo/semantics/openAccess Reconocimiento 4.0 Internacional. (CC BY) |
| dc.source.none.fl_str_mv | Molecules. 2017; 22(12):2083 reponame:IPMON en REDI instname:Institut Pasteur de Montevideo instacron:Institut Pasteur de Montevideo |
| dc.subject.none.fl_str_mv | Chronic Lymphocytic Leukemia Lipoprotein lipase Cancer Prognostic Markers Ciencias Médicas y de la Salud Medicina Básica Inmunología |
| dc.title.none.fl_str_mv | Lipoprotein lipase expression in chronic lymphocytic leukemia: New insights into leukemic progression |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article Aceptado info:eu-repo/semantics/acceptedVersion |
| description | Lipoprotein lipase (LPL) is a central enzyme in lipid metabolism. Due to its catalytic activity, LPL is involved in metabolic pathways exploited by various solid and hematologic malignancies to provide an extra energy source to the tumor cell. We and others described a link between the expression of LPL in the tumor cell with a poor clinical outcome of patients suffering Chronic Lymphocytic Leukemia (CLL). This leukemia is characterized by a slow accumulation of mainly quiescent clonal CD5 positive B cells that infiltrates secondary lymphoid organs, bone marrow and peripheral blood. Despite the usefulness of LPL for CLL prognosis, its functional role and the molecular mechanisms regulating its expression are still matter of debate. Herein we address some of these questions reviewing the current state of the art of LPL research in CLL and providing some insights into where currently unexplored questions may lead to. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_b607f3ff2f332677b0fbbbe86d4c4b71 |
| identifier_str_mv | Prieto, D; Oppezzo, P(2017). Lipoprotein Lipase Expression in Chronic Lymphocytic Leukemia: New Insights into Leukemic Progression. Molecules,1-9. FMV_2_2011_1_7323 |
| instacron_str | Institut Pasteur de Montevideo |
| institution | Institut Pasteur de Montevideo |
| instname_str | Institut Pasteur de Montevideo |
| language | eng |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:redi.anii.org.uy:20.500.12381/127 |
| publishDate | 2017 |
| publishDateSort | 2017 |
| publisher.none.fl_str_mv | MDPI |
| reponame_str | IPMON en REDI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Acceso abierto Reconocimiento 4.0 Internacional. (CC BY) |
| spelling | Lipoprotein lipase expression in chronic lymphocytic leukemia: New insights into leukemic progressionPrieto, DanielOppezzo, PabloChronic Lymphocytic LeukemiaLipoprotein lipaseCancerPrognostic MarkersCiencias Médicas y de la SaludMedicina BásicaInmunologíaLipoprotein lipase (LPL) is a central enzyme in lipid metabolism. Due to its catalytic activity, LPL is involved in metabolic pathways exploited by various solid and hematologic malignancies to provide an extra energy source to the tumor cell. We and others described a link between the expression of LPL in the tumor cell with a poor clinical outcome of patients suffering Chronic Lymphocytic Leukemia (CLL). This leukemia is characterized by a slow accumulation of mainly quiescent clonal CD5 positive B cells that infiltrates secondary lymphoid organs, bone marrow and peripheral blood. Despite the usefulness of LPL for CLL prognosis, its functional role and the molecular mechanisms regulating its expression are still matter of debate. Herein we address some of these questions reviewing the current state of the art of LPL research in CLL and providing some insights into where currently unexplored questions may lead to.Agencia Nacional de Investigación e InnovaciónMDPI2019-10-15T15:36:43Z2019-10-15T15:36:43Z2017Artículoinfo:eu-repo/semantics/articleAceptadoinfo:eu-repo/semantics/acceptedVersion9 p.Prieto, D; Oppezzo, P(2017). Lipoprotein Lipase Expression in Chronic Lymphocytic Leukemia: New Insights into Leukemic Progression. Molecules,1-9.http://hdl.handle.net/20.500.12381/127FMV_2_2011_1_7323https://doi.org/10.3390/molecules22122083Molecules. 2017; 22(12):2083reponame:IPMON en REDIinstname:Institut Pasteur de Montevideoinstacron:Institut Pasteur de MontevideoengMoleculesAcceso abiertoinfo:eu-repo/semantics/openAccessReconocimiento 4.0 Internacional. (CC BY)oai:redi.anii.org.uy:20.500.12381/1272026-06-16T05:20:18Z |
| spellingShingle | Lipoprotein lipase expression in chronic lymphocytic leukemia: New insights into leukemic progression Prieto, Daniel Chronic Lymphocytic Leukemia Lipoprotein lipase Cancer Prognostic Markers Ciencias Médicas y de la Salud Medicina Básica Inmunología |
| status_str | acceptedVersion |
| title | Lipoprotein lipase expression in chronic lymphocytic leukemia: New insights into leukemic progression |
| title_full | Lipoprotein lipase expression in chronic lymphocytic leukemia: New insights into leukemic progression |
| title_fullStr | Lipoprotein lipase expression in chronic lymphocytic leukemia: New insights into leukemic progression |
| title_full_unstemmed | Lipoprotein lipase expression in chronic lymphocytic leukemia: New insights into leukemic progression |
| title_short | Lipoprotein lipase expression in chronic lymphocytic leukemia: New insights into leukemic progression |
| title_sort | Lipoprotein lipase expression in chronic lymphocytic leukemia: New insights into leukemic progression |
| topic | Chronic Lymphocytic Leukemia Lipoprotein lipase Cancer Prognostic Markers Ciencias Médicas y de la Salud Medicina Básica Inmunología |
| url | http://hdl.handle.net/20.500.12381/127 https://doi.org/10.3390/molecules22122083 |