Exploring a gene co-expression network throughout the trypanosoma cruzi life cycle
Información suplementaria en: https://doi.org/10.1186/s12864-025-12095-7.
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| Format: | article |
| Language: | English |
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2025
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| Online Access: | https://hdl.handle.net/20.500.12008/53925 |
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| _version_ | 1868890149479251968 |
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| author | Inchausti, Lucas |
| author2 | Martín Menoni, Alvaro Pérez-Díaz, Leticia Garat, Beatriz Duhagon, María Ana Sotelo-Silveira, José Roberto De Gaudenzi, Javier G. Smircich, Pablo |
| author2_role | author author author author author author author |
| author_browse | De Gaudenzi, Javier G. Duhagon, María Ana Garat, Beatriz Inchausti, Lucas Martín Menoni, Alvaro Pérez-Díaz, Leticia Smircich, Pablo Sotelo-Silveira, José Roberto |
| author_facet | Inchausti, Lucas Martín Menoni, Alvaro Pérez-Díaz, Leticia Garat, Beatriz Duhagon, María Ana Sotelo-Silveira, José Roberto De Gaudenzi, Javier G. Smircich, Pablo |
| author_role | author |
| collection | COLIBRI |
| dc.contributor.none.fl_str_mv | Inchausti Lucas, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. Martín Menoni Alvaro, Universidad de la República (Uruguay). Facultad de Ingeniería. Pérez-Díaz Leticia, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. Garat Beatriz, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. Duhagon María Ana, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. Sotelo-Silveira José Roberto, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. De Gaudenzi Javier G. Smircich Pablo, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. |
| dc.creator.none.fl_str_mv | Inchausti, Lucas Martín Menoni, Alvaro Pérez-Díaz, Leticia Garat, Beatriz Duhagon, María Ana Sotelo-Silveira, José Roberto De Gaudenzi, Javier G. Smircich, Pablo |
| dc.date.none.fl_str_mv | 2025 2026-03-18T14:33:43Z 2026-03-18T14:33:43Z |
| dc.format.none.fl_str_mv | 17 h application/pdf |
| dc.identifier.none.fl_str_mv | Inchausti, L, Martín Menoni, A, Pérez-Díaz, L [y otros autores]. "Exploring a gene co-expression network throughout the trypanosoma cruzi life cycle". BMC Genomics. [en línea] 2025, 26: 916. 17 h. DOI: 10.1186/s12864-025-12095-7 1471-2164 https://hdl.handle.net/20.500.12008/53925 10.1186/s12864-025-12095-7 |
| dc.language.none.fl_str_mv | en eng |
| dc.publisher.none.fl_str_mv | Springer |
| dc.relation.none.fl_str_mv | BMC Genomics, 2025, 26: 916 |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.none.fl_str_mv | Trypanosoma cruzi Chagas disease Gene co-expression network analysis Post-transcriptional regulation RNA-seq |
| dc.title.none.fl_str_mv | Exploring a gene co-expression network throughout the trypanosoma cruzi life cycle |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Información suplementaria en: https://doi.org/10.1186/s12864-025-12095-7. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_a087b09ca025ed27fde60bf04c3d40e7 |
| identifier_str_mv | Inchausti, L, Martín Menoni, A, Pérez-Díaz, L [y otros autores]. "Exploring a gene co-expression network throughout the trypanosoma cruzi life cycle". BMC Genomics. [en línea] 2025, 26: 916. 17 h. DOI: 10.1186/s12864-025-12095-7 1471-2164 10.1186/s12864-025-12095-7 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/53925 |
| publishDate | 2025 |
| publishDateSort | 2025 |
| publisher.none.fl_str_mv | Springer |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
| spelling | Exploring a gene co-expression network throughout the trypanosoma cruzi life cycleInchausti, LucasMartín Menoni, AlvaroPérez-Díaz, LeticiaGarat, BeatrizDuhagon, María AnaSotelo-Silveira, José RobertoDe Gaudenzi, Javier G.Smircich, PabloTrypanosoma cruziChagas diseaseGene co-expression network analysisPost-transcriptional regulationRNA-seqInformación suplementaria en: https://doi.org/10.1186/s12864-025-12095-7.Background: Trypanosoma cruzi, the causative agent of American trypanosomiasis (Chagas disease), is a protozoan parasite with a complex life involving multiple developmental stages in both its triatomine vector and mammalian host. Each stage is characterized by distinct morphological and functional traits. Intriguingly, T. cruzi exhibits polycistronic transcription, relying predominantly on post-transcriptional mechanisms for gene regulation. Methods: To delve deeper into the molecular aspects of this regulation, we performed gene co-expression network (GCN) analysis using transcriptomic data spanning all life-cycle stages of T. cruzi, offering insights into the coordinated expression patterns of functionally Linked gene groups. We examined the global network properties, identifying overrepresented functional pathways and highly connected hub genes. Additionally, we explored potential regulatory mechanisms within each module, focusing on conserved motifs in the 3’ untranslated regions (3’UTRs) of co-expressed genes. Results: Our approach led to the identification of thirteen distinct co-expressed gene modules, each enriched in specific biological processes, including metabolism, pathogenesis, chromatin regulation, cytoskeleton modulation, and cellular movement. Finally, our study highlighted hub genes within each module. Combining a guilt-by- association approach with structural alignments and HMM-HMM profile comparisons, we assigned putative functions to previously uncharacterized proteins. Motif analysis of 3’UTR sequences in co-expressed genes revealed conserved elements and potential regulatory protein factors. Conclusions: GCN analysis is a powerful tool for studying gene expression regulation. Our findings provide new insights into the regulatory networks of T. cruzi, identifying key genes and mechanisms underlying coordinated gene expression.SpringerInchausti Lucas, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología.Martín Menoni Alvaro, Universidad de la República (Uruguay). Facultad de Ingeniería.Pérez-Díaz Leticia, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología.Garat Beatriz, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología.Duhagon María Ana, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología.Sotelo-Silveira José Roberto, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología.De Gaudenzi Javier G.Smircich Pablo, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología.2026-03-18T14:33:43Z2026-03-18T14:33:43Z2025Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion17 happlication/pdfInchausti, L, Martín Menoni, A, Pérez-Díaz, L [y otros autores]. "Exploring a gene co-expression network throughout the trypanosoma cruzi life cycle". BMC Genomics. [en línea] 2025, 26: 916. 17 h. DOI: 10.1186/s12864-025-12095-71471-2164https://hdl.handle.net/20.500.12008/5392510.1186/s12864-025-12095-7reponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaenengBMC Genomics, 2025, 26: 916Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0)oai:colibri.udelar.edu.uy:20.500.12008/539252026-04-14T10:10:59Z |
| spellingShingle | Exploring a gene co-expression network throughout the trypanosoma cruzi life cycle Inchausti, Lucas Trypanosoma cruzi Chagas disease Gene co-expression network analysis Post-transcriptional regulation RNA-seq |
| status_str | publishedVersion |
| title | Exploring a gene co-expression network throughout the trypanosoma cruzi life cycle |
| title_full | Exploring a gene co-expression network throughout the trypanosoma cruzi life cycle |
| title_fullStr | Exploring a gene co-expression network throughout the trypanosoma cruzi life cycle |
| title_full_unstemmed | Exploring a gene co-expression network throughout the trypanosoma cruzi life cycle |
| title_short | Exploring a gene co-expression network throughout the trypanosoma cruzi life cycle |
| title_sort | Exploring a gene co-expression network throughout the trypanosoma cruzi life cycle |
| topic | Trypanosoma cruzi Chagas disease Gene co-expression network analysis Post-transcriptional regulation RNA-seq |
| url | https://hdl.handle.net/20.500.12008/53925 |