Pretreatment Hepatitis C Virus NS5A/NS5B resistance-associated substitutions in genotype 1 uruguayan infected patients
Hepatitis C Virus (HCV) infection treatment has dramatically changed with the advent of direct-acting antiviral agents (DAAs). However, the efficacy of DAAs can be attenuated by the presence of resistance-associated substitutions (RASs) before and after treatment. Indeed, RASs detected in DAA treatm...
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| Muut tekijät: | , , , , , , , , |
| Aineistotyyppi: | article |
| Kieli: | englanti |
| Julkaistu: |
2018
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| Aiheet: | |
| Linkit: | https://hdl.handle.net/20.500.12008/22071 |
| Tagit: |
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| _version_ | 1868890138580353024 |
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| author | Aldunate Caramori, Fabián |
| author2 | Echeverría Chagas, Natalia Chiodi, Daniela López, Pablo Sánchez Cicerón, Adriana Fajardo Rossi, Álvaro Sóñora, Martín Cristina, Juan Hernández, Nelia Moreno Karlen, María del Pilar |
| author2_role | author author author author author author author author author |
| author_browse | Aldunate Caramori, Fabián Chiodi, Daniela Cristina, Juan Echeverría Chagas, Natalia Fajardo Rossi, Álvaro Hernández, Nelia López, Pablo Moreno Karlen, María del Pilar Sánchez Cicerón, Adriana Sóñora, Martín |
| author_facet | Aldunate Caramori, Fabián Echeverría Chagas, Natalia Chiodi, Daniela López, Pablo Sánchez Cicerón, Adriana Fajardo Rossi, Álvaro Sóñora, Martín Cristina, Juan Hernández, Nelia Moreno Karlen, María del Pilar |
| author_role | author |
| collection | COLIBRI |
| dc.contributor.none.fl_str_mv | Aldunate Caramori, Fabián. Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares Echeverría Chagas, Natalia. Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares Chiodi, D. López, P. Sánchez-Cicerón, A. Fajardo Rossi, Álvaro. Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares Soñora, Martín. Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares Cristina, Juan. Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares Hernández, Nelia Moreno Karlen, María del Pilar. Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares |
| dc.creator.none.fl_str_mv | Aldunate Caramori, Fabián Echeverría Chagas, Natalia Chiodi, Daniela López, Pablo Sánchez Cicerón, Adriana Fajardo Rossi, Álvaro Sóñora, Martín Cristina, Juan Hernández, Nelia Moreno Karlen, María del Pilar |
| dc.date.none.fl_str_mv | 2018 2019-10-02T22:14:42Z 2019-10-02T22:14:42Z 20191001 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Aldunate Caramori, F. y otros. "Pretreatment Hepatitis C Virus NS5A/NS5B resistance-associated substitutions in genotype 1 uruguayan infected patients". Disease Markers, 2018, art. no. 2514901. doi: 10.1155/2018/2514901 0278-0240 https://hdl.handle.net/20.500.12008/22071 10.1155/2018/2514901 |
| dc.language.none.fl_str_mv | en eng |
| dc.publisher.none.fl_str_mv | Hindawi Publishing Corporation |
| dc.relation.none.fl_str_mv | Disease Markers, 2018, art. no. 2514901 |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess Licencia Creative Commons Atribución (CC –BY 4.0) |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.none.fl_str_mv | Hepacivirus Hepatitis C Antivirals DAAs |
| dc.title.none.fl_str_mv | Pretreatment Hepatitis C Virus NS5A/NS5B resistance-associated substitutions in genotype 1 uruguayan infected patients |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Hepatitis C Virus (HCV) infection treatment has dramatically changed with the advent of direct-acting antiviral agents (DAAs). However, the efficacy of DAAs can be attenuated by the presence of resistance-associated substitutions (RASs) before and after treatment. Indeed, RASs detected in DAA treatment-naïve HCV-infected patients could be useful for clinical management and outcome prediction. Although the frequency of naturally occurring HCV NS5A and NS5B RASs has been addressed in many countries, there are only a few reports on their prevalence in the South American region. The aim of this study was to investigate the presence of RASs to NS5A and NS5B inhibitors in a DAA treatment naïve cohort of Uruguayan patients infected with chronic hepatitis C and compare them with reports from other South American countries. Here, we found that naturally occurring substitutions conferring resistance to NS5A and NS5B inhibitors were present in 8% and 19.2,% respectively, of treatment-naïve HCV genotype 1 infected patients. Importantly, the baseline substitutions in NS5A and NS5B herein identified differ from the studies previously reported in Brazil. Furthermore, Uruguayan strains subtype 1a clustered within all major world clades, showing that HCV variants currently circulating in this country are characterized by a remarkable genetic diversity. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_94a2c98c05cdc4a6a91f20dde76a8f13 |
| identifier_str_mv | Aldunate Caramori, F. y otros. "Pretreatment Hepatitis C Virus NS5A/NS5B resistance-associated substitutions in genotype 1 uruguayan infected patients". Disease Markers, 2018, art. no. 2514901. doi: 10.1155/2018/2514901 0278-0240 10.1155/2018/2514901 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/22071 |
| publishDate | 2018 |
| publishDateSort | 2018 |
| publisher.none.fl_str_mv | Hindawi Publishing Corporation |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC –BY 4.0) |
| spelling | Pretreatment Hepatitis C Virus NS5A/NS5B resistance-associated substitutions in genotype 1 uruguayan infected patientsAldunate Caramori, FabiánEcheverría Chagas, NataliaChiodi, DanielaLópez, PabloSánchez Cicerón, AdrianaFajardo Rossi, ÁlvaroSóñora, MartínCristina, JuanHernández, NeliaMoreno Karlen, María del PilarHepacivirusHepatitis CAntivirals DAAsHepatitis C Virus (HCV) infection treatment has dramatically changed with the advent of direct-acting antiviral agents (DAAs). However, the efficacy of DAAs can be attenuated by the presence of resistance-associated substitutions (RASs) before and after treatment. Indeed, RASs detected in DAA treatment-naïve HCV-infected patients could be useful for clinical management and outcome prediction. Although the frequency of naturally occurring HCV NS5A and NS5B RASs has been addressed in many countries, there are only a few reports on their prevalence in the South American region. The aim of this study was to investigate the presence of RASs to NS5A and NS5B inhibitors in a DAA treatment naïve cohort of Uruguayan patients infected with chronic hepatitis C and compare them with reports from other South American countries. Here, we found that naturally occurring substitutions conferring resistance to NS5A and NS5B inhibitors were present in 8% and 19.2,% respectively, of treatment-naïve HCV genotype 1 infected patients. Importantly, the baseline substitutions in NS5A and NS5B herein identified differ from the studies previously reported in Brazil. Furthermore, Uruguayan strains subtype 1a clustered within all major world clades, showing that HCV variants currently circulating in this country are characterized by a remarkable genetic diversity.Hindawi Publishing CorporationAldunate Caramori, Fabián. Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones NuclearesEcheverría Chagas, Natalia. Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones NuclearesChiodi, D.López, P.Sánchez-Cicerón, A.Fajardo Rossi, Álvaro. Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones NuclearesSoñora, Martín. Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones NuclearesCristina, Juan. Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones NuclearesHernández, NeliaMoreno Karlen, María del Pilar. Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares2019-10-02T22:14:42Z2019-10-02T22:14:42Z201820191001Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfAldunate Caramori, F. y otros. "Pretreatment Hepatitis C Virus NS5A/NS5B resistance-associated substitutions in genotype 1 uruguayan infected patients". Disease Markers, 2018, art. no. 2514901. doi: 10.1155/2018/25149010278-0240https://hdl.handle.net/20.500.12008/2207110.1155/2018/2514901reponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaenengDisease Markers, 2018, art. no. 2514901Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad De La República. (Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC –BY 4.0)oai:colibri.udelar.edu.uy:20.500.12008/220712026-04-14T10:09:19Z |
| spellingShingle | Pretreatment Hepatitis C Virus NS5A/NS5B resistance-associated substitutions in genotype 1 uruguayan infected patients Aldunate Caramori, Fabián Hepacivirus Hepatitis C Antivirals DAAs |
| status_str | publishedVersion |
| title | Pretreatment Hepatitis C Virus NS5A/NS5B resistance-associated substitutions in genotype 1 uruguayan infected patients |
| title_full | Pretreatment Hepatitis C Virus NS5A/NS5B resistance-associated substitutions in genotype 1 uruguayan infected patients |
| title_fullStr | Pretreatment Hepatitis C Virus NS5A/NS5B resistance-associated substitutions in genotype 1 uruguayan infected patients |
| title_full_unstemmed | Pretreatment Hepatitis C Virus NS5A/NS5B resistance-associated substitutions in genotype 1 uruguayan infected patients |
| title_short | Pretreatment Hepatitis C Virus NS5A/NS5B resistance-associated substitutions in genotype 1 uruguayan infected patients |
| title_sort | Pretreatment Hepatitis C Virus NS5A/NS5B resistance-associated substitutions in genotype 1 uruguayan infected patients |
| topic | Hepacivirus Hepatitis C Antivirals DAAs |
| url | https://hdl.handle.net/20.500.12008/22071 |