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A Unique Mode of Coenzyme A Binding to the Nucleotide Binding Pocket of Human Metastasis Suppressor NME1

Coenzyme A (CoA) is a key cellular metabolite which participates in diverse metabolic pathways, regulation of gene expression and the antioxidant defense mechanism. Human NME1 (hNME1), which is a moonlighting protein, was identified as a major CoA-binding protein. Biochemical studies showed that hNM...

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Main Author: Tossounian, Maria-Armineh (author)
Other Authors: Hristov, Stefan Denchev (author), Semelak, Jonathan Alexis (author), Yu, Bess Yi Kun (author), Baczynska, Maria (author), Zhao, Yuhan (author), Estrin, Darío Ariel (author), Trujillo, Madia (author), Filonenko, Valeriy (author), Gouge, Jerome (author), Gout, Iván (author)
Format: article
Language:English
Published: 2023
Subjects:
CoAlation
NDPK-A structure
NM23-H1
NME1
X-ray crystallography
Coenzyme A
Metastasis suppressor
Molecular dynamics
Nucleotide binding
Protein-metabolite regulation
ADENINA
ARGININA
SITIOS DE UNIÓN
COENZIMA A
CRISTALOGRAFÍA POR RAYOS X
HUMANOS
NUCLEÓSIDO DIFOSFATO QUINASAS NM23
GENÉTICA
NUCLEÓTIDOS
TREONINA
Online Access:https://hdl.handle.net/20.500.12008/54159
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https://hdl.handle.net/20.500.12008/54159

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