Redox sensitive human mitochondrial aconitase and its interaction with frataxin: In vitro and in silico studies confirm that it takes two to tango

Mitochondrial aconitase (ACO2) has been postulated as a redox sensor in the tricarboxylic acid cycle. Its high sensitivity towards reactive oxygen and nitrogen species is due to its particularly labile [4Fe–4S]2+prosthetic group which yields an inactive [3Fe–4S]+cluster upon oxidation. Moreover, ACO...

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Bibliographic Details

Main Author:	Mansilla, Santiago (author)
Other Authors:	Tórtora, Verónica (author), Pignataro, Florencia (author), Sastre, Santiago (author), Castro, Ignacio (author), Chiribao, María Laura (author), Robello, Carlos (author), Zeida, Ari (author), Santos, Javier (author), Castro, Laura (author)
Format:	article
Language:	English
Published:	2023
Subjects:	Mitochondrial aconitase Frataxin Iron-sulfur protein Tricarboxylic acid cycle (TCA cycle) (Krebs cycle) Mitochondria protein-protein interaction MAPAS DE INTERACCIÓN DE PROTEÍNAS ÁCIDOS TRICARBOXÍLICOS ENZIMAS ENFERMEDADES MITOCONDRIALES FRATAXINA CICLO DEL ÁCIDO CÍTRICO ACONITATO HIDRATASA
Online Access:	https://hdl.handle.net/20.500.12008/53298
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