Mitofusins modulate the increase in mitochondrial length, bioenergetics and secretory phenotype in therapy-induced senescent melanoma cells

Cellular senescence is an endpoint of chemotherapy, and targeted therapies in melanoma and the senescence-associated secretory phenotype (SASP) can affect tumor growth and microenvironment, influencing treatment outcomes. Metabolic interventions can modulate the SASP, and an enhanced mitochondrial e...

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Bibliographic Details

Main Author:	Martínez, Jennyfer (author)
Other Authors:	Tarallo, Doménica (author), Martínez-Palma, Laura (author), Victoria, Sabina (author), Bresque, Mariana (author), Rodríguez-Bottero, Sebastián (author), Marmisolle, Inés (author), Escande, Carlos (author), Cassina, Patricia (author), Casanova, Gabriela (author), Bollati-Fogolín, Mariela (author), Agorio, Caroline (author), Moreno, María (author), Quijano, Celia (author)
Format:	article
Language:	English
Published:	2019
Subjects:	Bioenergetics Cell senescence Hemotherapy Melanoma, Mitochondria Mitofusin
Online Access:	https://hdl.handle.net/20.500.12008/26838 https://doi.org/10.1042/BCJ20190405
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