miRNA independent hepacivirus variants suggest a strong evolutionary pressure to maintain miR-122 dependence

Hepatitis C virus (HCV) requires the liver specific micro-RNA (miRNA), miR-122, to replicate. This was considered unique among RNA viruses until recent discoveries of HCV-related hepaciviruses prompting the question of a more general miR-122 dependence. Among hepaciviruses, the closest known HCV rel...

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Bibliographic Details

Main Author:	Yu, Y. (author)
Other Authors:	Scheel, T. K. H. (author), Luna, J. M. (author), Chung, H. (author), Nishiuchi, E. (author), Scull, M. A. (author), Echeverría Chagas, Natalia (author), Ricardo-Lax, I. (author), Kapoor, A. (author), Lipkin, I. W. (author), Divers, T. J. (author), Antczak, D. F. (author), Tennant, B. C. (author), Rice, C. M. (author)
Format:	article
Language:	English
Published:	2017
Subjects:	MicroRNAs Carcinoma Hepatocellular HCC tissues
Online Access:	https://hdl.handle.net/20.500.12008/22739
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