Home, head direction stability, and grid cell distortion
The home is a unique location in the life of humans and animals. In rats, home presents itself as a multicompartmental space that involves integrating navigation through subspaces. Here we embedded the laboratory rat’s home cage in the arena, while recording neurons in the animal’s parasubiculum and...
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| Format: | article |
| Langue: | anglais |
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2020
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| Accès en ligne: | https://hdl.handle.net/20.500.12008/31675 |
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| _version_ | 1868890115622830080 |
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| author | Sanguinetti Scheck, Juan Ignacio |
| author2 | Brecht, M. |
| author2_role | author |
| author_browse | Brecht, M. Sanguinetti Scheck, Juan Ignacio |
| author_facet | Sanguinetti Scheck, Juan Ignacio Brecht, M. |
| author_role | author |
| collection | COLIBRI |
| dc.contributor.none.fl_str_mv | Sanguinetti Scheck Juan Ignacio, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. Brecht M. |
| dc.creator.none.fl_str_mv | Sanguinetti Scheck, Juan Ignacio Brecht, M. |
| dc.date.none.fl_str_mv | 2020 2022-05-26T12:41:49Z 2022-05-26T12:41:49Z |
| dc.format.none.fl_str_mv | 15 h. application/pdf |
| dc.identifier.none.fl_str_mv | Sanguinetti Scheck, J y Brecht, M. "Home, head direction stability, and grid cell distortion". Journal of Neurophysiology. [en línea] 2020, 123(4): 1392–1406. 15 h. DOI: 10.1152/jn.00518.2019 1522-1598 https://hdl.handle.net/20.500.12008/31675 10.1152/jn.00518.2019 |
| dc.language.none.fl_str_mv | en eng |
| dc.publisher.none.fl_str_mv | American Physiological Society |
| dc.relation.none.fl_str_mv | Journal of Neurophysiology, 2020, 123(4): 1392–1406 |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess Licencia Creative Commons Atribución (CC - By 4.0) |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.none.fl_str_mv | Grid cell Head direction Home Homing Navigation |
| dc.title.none.fl_str_mv | Home, head direction stability, and grid cell distortion |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | The home is a unique location in the life of humans and animals. In rats, home presents itself as a multicompartmental space that involves integrating navigation through subspaces. Here we embedded the laboratory rat’s home cage in the arena, while recording neurons in the animal’s parasubiculum and medial entorhinal cortex, two brain areas encoding the animal’s location and head direction. We found that head direction signals were unaffected by home cage presence or translocation. Head direction cells remain globally stable and have similar properties inside and outside the embedded home. We did not observe egocentric bearing encoding of the home cage. However, grid cells were distorted in the presence of the home cage. While they did not globally remap, single firing fields were translocated toward the home. These effects appeared to be geometrical in nature rather than a home-specific distortion and were not dependent on explicit behavioral use of the home cage during a hoarding task. Our work suggests that medial entorhinal cortex and parasubiculum do not remap after embedding the home, but local changes in grid cell activity overrepresent the embedded space location and might contribute to navigation in complex environments. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_866dd9e4f37d0cede86da5d4218f15ec |
| identifier_str_mv | Sanguinetti Scheck, J y Brecht, M. "Home, head direction stability, and grid cell distortion". Journal of Neurophysiology. [en línea] 2020, 123(4): 1392–1406. 15 h. DOI: 10.1152/jn.00518.2019 1522-1598 10.1152/jn.00518.2019 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/31675 |
| publishDate | 2020 |
| publishDateSort | 2020 |
| publisher.none.fl_str_mv | American Physiological Society |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| spelling | Home, head direction stability, and grid cell distortionSanguinetti Scheck, Juan IgnacioBrecht, M.Grid cellHead directionHomeHomingNavigationThe home is a unique location in the life of humans and animals. In rats, home presents itself as a multicompartmental space that involves integrating navigation through subspaces. Here we embedded the laboratory rat’s home cage in the arena, while recording neurons in the animal’s parasubiculum and medial entorhinal cortex, two brain areas encoding the animal’s location and head direction. We found that head direction signals were unaffected by home cage presence or translocation. Head direction cells remain globally stable and have similar properties inside and outside the embedded home. We did not observe egocentric bearing encoding of the home cage. However, grid cells were distorted in the presence of the home cage. While they did not globally remap, single firing fields were translocated toward the home. These effects appeared to be geometrical in nature rather than a home-specific distortion and were not dependent on explicit behavioral use of the home cage during a hoarding task. Our work suggests that medial entorhinal cortex and parasubiculum do not remap after embedding the home, but local changes in grid cell activity overrepresent the embedded space location and might contribute to navigation in complex environments.American Physiological SocietySanguinetti Scheck Juan Ignacio, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología.Brecht M.2022-05-26T12:41:49Z2022-05-26T12:41:49Z2020Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion15 h.application/pdfSanguinetti Scheck, J y Brecht, M. "Home, head direction stability, and grid cell distortion". Journal of Neurophysiology. [en línea] 2020, 123(4): 1392–1406. 15 h. DOI: 10.1152/jn.00518.20191522-1598https://hdl.handle.net/20.500.12008/3167510.1152/jn.00518.2019reponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaenengJournal of Neurophysiology, 2020, 123(4): 1392–1406Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC - By 4.0)oai:colibri.udelar.edu.uy:20.500.12008/316752026-04-14T10:09:47Z |
| spellingShingle | Home, head direction stability, and grid cell distortion Sanguinetti Scheck, Juan Ignacio Grid cell Head direction Home Homing Navigation |
| status_str | publishedVersion |
| title | Home, head direction stability, and grid cell distortion |
| title_full | Home, head direction stability, and grid cell distortion |
| title_fullStr | Home, head direction stability, and grid cell distortion |
| title_full_unstemmed | Home, head direction stability, and grid cell distortion |
| title_short | Home, head direction stability, and grid cell distortion |
| title_sort | Home, head direction stability, and grid cell distortion |
| topic | Grid cell Head direction Home Homing Navigation |
| url | https://hdl.handle.net/20.500.12008/31675 |